Postdoctoral Researcher - Cardiovascular Gene Editing/Delivery
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Job Description
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.
At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.
With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.
We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!
POSTDOCTORAL RESEARCHER - CARDIOVASCULAR GENE EDITING/ DELIVERY
SUMMARY:
We are seeking an enthusiastic postdoctoral scientist interested in using CRISPR gene editing to address root causes of heart failure and arrhythmia to join the Cardiovascular Drug Discovery group, a multi-disciplinary team of energetic researchers. The successful candidate will work in a matrix group environment to explore in vivo gene editing for cardiovascular diseases. He/She will work independently to conceptualize, design and execute experiments using rodent and human cell models. Background in RNA, molecular biology, and CRISPR/Cas systems are essential for the position. Experience in cardiovascular biology and drug delivery is a plus.
RESPONSIBILITIES:
- Design, execute and troubleshoot experiments relevant to the postdoctoral project
- Formulate solutions for delivery of therapeutics in vitro and in vivo and contribute to optimization.
- Measure and analyze pharmacodynamic and functional effects of treatments in rodent and cell models of disease.
- Present results at internal and external scientific meetings.
- Prepare manuscript for publication.
REQUIREMENTS:
- Ph.D. in molecular biology, biochemistry, or related fields with 0-3 years of postgraduate training.
- Strong laboratory skills in molecular biology and biochemical assays, e.g. RNA and protein isolation, RT-qPCR, ELISA, Western Blotting.
- Proficiency in rodent handling, dosing (IV, SC, IM) and necropsy.
- Hands-on experience with CRISPR/Cas systems.
- Excellent written and verbal communication skills.
- Required to be full-time onsite at Carlsbad, CA.
PREFERRED SKILLS:
- Experience with in vivo imaging systems (IVIS) is desirable.
- Exposure to non-viral vector in vivo delivery desirable.
- Experience with lipid formulation for in vivo and in vitro delivery.
- Experience with cardiomyocyte culture (primary and/or iPSC-CMs).
- Exposure to cardiac functional assessments, including echocardiography.
- Experience with confocal microscopy.
Please visit our website, http://www.ionis.com, for more information about Ionis and to apply for this position; reference requisition #IONIS003471
Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits
Full Benefits Link: https://www.ionis.com/careers/working-at-ionis/#:~:text=to%20Applicants%C2%A0%C2%BB-,Benefits,-Employees%20are%20rewarded
The pay scale for this position is $78,000 to $87,000
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
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