Associate Director, In Vivo Pharmacology & Translational Science

Company Summary:

Flagship Labs 111 Inc. (FL111) is a privately held, early-stage biotechnology company pioneering a novel platform harnessing innovations in chemistry and machine learning to address challenging biology. FL111 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL111 from platform validation to patient impact. We are seeking collaborative, creative and relentless problem solvers that share our passion for impact to join us!

Position Summary

We are seeking an Associate Director, In Vivo Pharmacology & Translational Science to lead all in vivo activities from early discovery through preclinical development. This role will own the design, execution, and interpretation of in vivo PK, PD, and efficacy studies, with a strong focus on oncology and small-molecule modalities. The ideal candidate is an accomplished in vivo pharmacologist who can manage CROs and external technicians, while also rolling up their sleeves to troubleshoot and ensure studies are delivered on time. This individual will build and scale our in vivo capabilities, establish best practices, and serve as the in vivo leader at FL111.

Key Responsibilities:

• Project leadership: serve as the in vivo lead on project teams, accountable for end-to-end planning, execution, and delivery of all in vivo PK, PD, and efficacy studies.
• Study design and execution: develop and execute in vivo studies to evaluate compound exposure (PK), target engagement and biomarkers (PD), and anti-tumor activity (efficacy) across various oncology models and small molecule modalities; hands-on execution.
• CRO management and operations: lead the day-to-day management of external in vivo work at CROs, including protocol review, study monitoring, data quality oversight, and vendor qualification/onboarding.
• Collaborate closely with Chemistry, DMPK, and Biology teams to refine compound design and formulation based on integrated PK/PD/efficacy data.
• Documentation & Communication: Establish fit-for-purpose in vivo workflows and SOPs, document experiments & results, and communicate scientific results effectively through clear presentations.

Qualitifications & Skills:

• Ph.D./M.D. with 5-10+ years of industry experience in preclinical development of small molecule modalities.
• Deep expertise in Oncology and Cancer Biology, specifically in designing and executing studies using diverse in vivo oncology models (e.g., CDX, PDX, humanized, syngeneic).
• Expertise in the preclinical characterization of heterobifunctional small molecules (e.g., PROTACs)
• Proven ability to lead projects, integrating PK, PD, and efficacy data to drive compound optimization and Go/No Go decisions.
• Extensive experience managing external in vivo work at CROs, including experimental design, study monitoring, and data quality oversight.

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $157,000 - $198,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL111 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL111's good faith estimate as of the date of publication and may be modified in the future.