Associate Medical Director, Neurology Clinical Development

About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach.

Position Purpose:

The Associate Medical Director, Neurology Clinical Development will play a key role in the planning, execution, and interpretation of clinical studies focused on transformative therapies for life-threatening neurological diseases. This individual will contribute medical and scientific expertise to advance programs from early development through late-stage studies and regulatory submission.

The Associate Medical Director will support cross-functional teams, interface with external partners and investigators, and help ensure the highest standards of scientific and clinical rigor are maintained across all programs. This role will work collaboratively with the Medical Director and Senior Medical Director in Neurology Clinical Development and will report to the Medical Director in Neurology Clinical Development.

Key Responsibilities:

Clinical Development & Execution

• Support the design, implementation, and oversight of clinical trials in neurology, including protocol development, study conduct, and data analysis
• Contribute to the medical and scientific content of key clinical documents (e.g. protocols, investigator brochures, clinical study reports, and regulatory submissions)
• Participate in clinical data review, interpretation, and presentation to support timely and informed decision-making
• Collaborate with safety/pharmacovigilance on safety review and signal evaluation
• Provide medical monitoring and clinical oversight for ongoing studies under the supervision of the Medical Director or Senior Medical Director
• Maintain effective collaboration with CROs, investigators, and academic partners to ensure study quality and adherence to timelines
• Ensure compliance with GCP, ICH, and all applicable regulatory and ethical guidelines

Scientific & Strategic Contribution

• Support the development of clinical development strategies and study designs in alignment with program objectives and scientific rationale
• Contribute to the development, execution, and continuous refinement of global Clinical Development Plans (CDPs)
• Integrate emerging data, literature, and competitive intelligence to inform ongoing program decisions and ensure scientific relevance and rigor
• Collaborate closely with cross-functional partners including regulatory, clinical development operations, and biostatistics to ensure consistency and accuracy in study execution
• Participate in internal discussions and presentations to communicate key scientific insights, data interpretations, and development updates
• Contribute to the preparation and review of strategic and regulatory documents, including target product profiles, clinical sections of IND/CTA submissions, and briefing packages

External Engagement & Communication

• Engage and collaborate with key opinion leaders (KOLs) and academic investigators to inform study designs and strengthen the scientific foundation of development programs
• Represent the clinical development organization at scientific and medical meetings, advisory boards, and key investigator interactions
• Contribute to the authorship of abstracts, manuscripts, and scientific presentations that communicate program progress and data to the broader scientific and clinical community

Leadership & Collaboration

• Provide clinical and scientific leadership with cross-functional clinical teams, fostering an environment of accountability, curiosity, and collaborative problem solving
• Partner effectively with internal stakeholders across clinical development operations, biostatistics, regulatory, and commercial to ensure scientific and operational excellence in study execution
• Serve as a clinical development point of contact in collaborations and partnerships, helping to maintain strong relationships built on scientific integrity, transparency, and shared objectives

Required Skills & Experience:

• MD, MD/PhD, or PharmD candidates with relevant clinical development experience in neurology, rare/orphan, or genetic diseases
• Board certified or eligible in neurology, pediatrics, or a relevant specialty (for MDs)
• Minimum 5 years experience contributing to the design, conduct, or medical oversight of clinical trials (industry or academic) required
• Familiarity with FDA/EMA regulations and ICH/GCP guidelines
• Strong scientific, analytical, and organizational skills
• Demonstrated ability to interpret complex clinical and scientific data
• Excellent communication and presentation skills, with the ability to collaborate effectively across multidisciplinary teams
• High personal integrity, scientific rigor, and strong commitment to advancing therapies for patients with serious neurological diseases

Location(s):

Stoke operates in Bedford, MA. This position is a hybrid position with an office setting based in our Bedford, MA location.

Travel:

This position will require approximately 20% travel (domestic and international).

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $200,000 - $235,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.