Vice President, Distribution & Trade - Market Access Field

About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach.

Position Purpose:

The Vice President, Distribution & Trade- Market Access Field will be responsible for designing, implementing, and managing Stoke's specialty distribution strategy for its first potential commercial product. This role will ensure seamless patient access, compliant operations, and a best-in-class distribution model tailored for zorevunersen.

Reporting to the VP of Market Access, this individual will serve as the company's lead expert on trade and channel distribution, overseeing partnerships with specialty distributors (SDs), specialty pharmacies (SPs), and third-party logistics (3PL) providers.

The ideal candidate brings deep operational experience in specialty product distribution, rare disease commercialization, state licensing, and DSCSA serialization.

Key Responsibilities:

Distribution & Trade Strategy

• Design and execute the U.S. specialty distribution and trade strategy aligned with the product access and commercial plan.
• Establish and manage relationships with channel partners (SDs, SPs, 3PLs) to ensure timely, compliant product distribution.
• Lead selection, contracting, and performance management of all trade and distribution vendors.
• Develop and monitor SLAs, KPIs, and reporting to ensure optimal service levels and inventory management.

Operational Execution

• Oversee the operational readiness of the distribution network to support launch, including order management, returns processing, and product traceability.
• Manage day-to-day trade operations, including data flow, order-to-cash processes, and performance reviews with distribution partners.
• Ensure DSCSA serialization and traceability compliance across the distribution network.
• Oversee state licensing activities related to product distribution and ensure all licenses are obtained, maintained, and compliant with federal and state regulations.

Cross-Functional Collaboration

• Partner closely within Market Access and across Finance. Supply Chain, Quality, Regulatory, and Patient Services to ensure an integrated, compliant, and patient-centered distribution model.
• Collaborate with Supply Chain and Quality to align on product release, distribution, and logistics.
• Support Finance and Legal in contract negotiation, distribution fee structures, and compliance with fair market value standards.

Compliance & Governance

• Ensure all trade and distribution activities comply with DSCSA, PDMA, GDP, and other applicable regulations.
• Develop and maintain standard operating procedures (SOPs) for distribution, product handling, and data integrity.
• Collaborate with Compliance and QA functions to support audits and ongoing monitoring.

Required Skills & Experience:

• 10+ years of experience in U.S. pharmaceutical/biotech trade, distribution, or channel operations; prior experience in rare disease or specialty biologics
• Bachelor's degree in business, Supply Chain, Life Sciences, or related field (MBA preferred).
• Proven track record launching specialty products and managing limited distribution networks.
• Deep understanding of DSCSA serialization, state licensing, GDP, and 3PL operations.
• Start-up Experience- Ability to work hands-on, build from scratch, and manage multiple vendors and consultants in a resource-limited environment.
• Strong vendor management and negotiation experience.
• Excellent project management and communication skills.
• Analytical mindset with strong attention to operational details.
• Passion for rare disease and improving patient access.

Location(s):

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is field-based currently based in Bedford and will later be based in Waltham.

Travel:

This position will require approximately 30%-50% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $333,000 - $375,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.