Analytical Development Research Scientist

Job Description

General summary:

Vertex is seeking a talented scientist to join our small molecules Analytical Development group in Boston, MA. This individual will play a central role in advancing transformative medicines by leading select analytical chemistry activities to support small molecules, oligonucleotides, peptides, lipid nanoparticle (LNP)-based formulations and conjugated therapeutics development programs from preclinical through to Phase 1. This role includes active participation in cross‑functional project team meetings, working collaboratively with other R&D functions to resolve project challenges. The ability to work both independently and in a matrix team environment is essential to succeed in this position.

Key Duties and Responsibilities:

• Project oversight: participate in and support cross-functional teams and effectively communicate issues and solutions to colleagues at all levels within the organization
• Strategy: contributes to the development, alignment and execution of analytical project team plans and strategies to support drug substance and drug product development including formulation‑relevant analytical method development, stability, physicochemical characterization, and validation activities
• Laboratory expertise: apply hands‑on analytical skills and understanding in laboratory techniques routinely used in the analysis of drug substance, formulated drug product, and lipid‑based or particle‑based delivery systems
• Collaboration: work both independently and collaboratively within a matrix team environment
• Communication: demonstrated ability to effectively present results in both oral and written reports and to productively disseminate ideas across discipline and project boundaries
• Continuous improvement: develop, contribute, and support improvements in analytical workflows, processes, and ways of working that improve productivity, efficiency, and overall effectiveness

Knowledge and skills:

• The ability to work successfully in both a team/matrix environment as well as independently
• Experience developing and applying analytical methods to support formulation development and characterization, including particle‑based or lipid‑based delivery systems
• Technical expertise in analytical techniques supporting LNP and particle‑based formulation characterization (e.g., LC-CAD, SEC-MALS, DLS, NTA, zeta potential), with additional experience in small‑molecule analytical methods considered a plus
• Strong troubleshooting skills and problem-solving capabilities
• Strong analytical data assessment, review and interpretation skills
• Demonstrated experience in communication of technical data: writing reports and presentation skills
• High attention to detail
• Ability to work in a fast-paced environment, managing priorities and maintaining timelines

Education and Experience:

• Ph.D. (or equivalent degree) and 0-3 years of relevant post-doctoral employment experience, or
• Masters Degree (or equivalent degree) and 3+ years of relevant employment experience, or
• Bachelors Degree (or equivalent degree) and 6+ years
• Relevant professional analytical development experience in the pharmaceutical industry

Pay Range:

$102,800 - $154,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com