Director of R&D

Paragon GenomicsFremont, CA

$170,000 - $200,000 / year

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Overview

Schedule

Full-time

Career level

Director

Compensation

$170,000-$200,000/year

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Job Description

Job Title: Director of R&DJob Location: Fremont, CASchedule: Full TimeBase Salary Range: $170,000 - $200,000Reorts to the Chief Executive OfficerPOSITION SUMMARYDirector of R&D will lead Paragon Genomics’ assay design and development strategy and execution for next-generation sequencing products and laboratory developed tests. This leader will oversee the design, feasibility assessment, analytical validation, and transfer of novel assays, with particular focus on precision oncology, liquid biopsy, minimal residual disease (MRD), and other high-value molecular diagnostics applications.The ideal candidate brings deep expertise in molecular biology, NGS assay and workflow development, regulated product development, and cross-functional leadership. This role is expected to build technical capability, shape the R&D roadmap, and partner closely with bioinformatics, operations, quality, product management, and commercial teams to translate scientific innovation into robust products.PRIMARY RESPONSIBILITIES

Leadership & Mentorship: Provide strategic direction for assay development programs and ensure alignment with company goals, portfolio priorities, and launch timelines. Recruit, mentor, and develop a high-performing team of scientists in a collaborative, fast-paced environment.
Innovation: Identify and evaluate emerging technologies in molecular diagnostics, oncology, and NGS. Drive ideation and feasibility work for new tools, chemistries, and workflows that improve assay performance, scalability, and cost efficiency.
Research Oversight: Oversee experimental design, study execution, data review, and technical decision-making across innovation, assay development, and validation activities. Ensure scientific rigor, reproducibility, and clear documentation.
Assay Design & Optimization: Lead the development and optimization of end-to-end workflows, including target selection, primer and probe design, library preparation, target enrichment, sequencing, and integration with bioinformatics pipelines for variant detection and reporting.
Product Development: Drive the lifecycle of NGS-based assays and LDTs from concept through analytical validation and handoff for launch. Support applications such as gene fusion detection, expression profiling, biomarker-driven diagnostics, and emerging MRD-focused workflows.
Cross-functional Collaboration: Partner closely with Product Management, Marketing, Operations, Quality, Regulatory, and Bioinformatics to align technical programs with business objectives and successful product commercialization.
Communication: Present study plans, technical findings, milestones, and recommendations to internal stakeholders, executive leadership, and external collaborators as needed.

QUALIFICATIONS

PhD in Molecular Biology, Pathology, Genetics, Biochemistry, or a related scientific discipline; advanced industry leadership experience required.
10+ years of progressive experience in molecular research and development within life sciences, clinical diagnostics, or regulated biotech environments, including meaningful team leadership responsibility.
Demonstrated expertise in NGS assay development, library preparation, target enrichment, sequencing workflows, and molecular diagnostic methods.
Strong track record of developing innovative assays and advancing programs from research through development, validation, and transfer for commercialization.
Hands-on knowledge of assay design principles, including gene target curation, primer and probe design, nucleic acid quantification and QC, and bioinformatics integration for variant analysis.
Experience working in regulated settings and familiarity with LDT validation, design controls, and regulatory documentation or submissions.
Direct experience with MRD assay development, especially NGS-based MRD, cell-free DNA, or other ultra-sensitive oncology monitoring applications, is a strong plus.
Excellent communication, organizational, and cross-functional collaboration skills, with the ability to translate complex technical issues into clear decisions and action plans.
Experience in molecular oncology, hematologic malignancies, liquid biopsy, cell-free DNA, methylation, Sanger sequencing, MLPA, or related advanced molecular techniques is strongly preferred.

COMPENSATION & BENEFITSParagon Genomics offers a competitive compensation package and comprehensive benefits for eligible employees, including medical, dental, vision, life insurance, flexible spending accounts, 401(k), paid time off, and stock options. Final compensation will depend on experience, qualifications, and internal equity.OUR OPPORTUNITYParagon Genomics is a dynamic and growing genomics company headquartered in Fremont, California. We develop and commercialize breakthrough target enrichment solutions for next-generation sequencing and support customers across fast-growing applications in oncology and precision medicine.Our patented CleanPlex® technology addresses critical throughput and efficiency bottlenecks in NGS target enrichment workflows. We are building a team of talented scientists, engineers, and business professionals who thrive in a collaborative, entrepreneurial environment and are motivated by the opportunity to translate innovative science into real-world impact.ADDITIONAL INFORMATIONThis job description is not intended to be an exhaustive list of duties, responsibilities, or qualifications. Paragon Genomics reserves the right to modify or assign additional responsibilities as business needs evolve.Paragon Genomics is an Equal Opportunity Employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, veteran status, disability, or any other status protected by applicable federal, state, or local law. For information about how personal data is processed and stored, please review Paragon Genomics' Job Applicant Privacy Policy.

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FAQs About Director of R&D Jobs at Paragon Genomics

What is the work location for this position at Paragon Genomics?

This job at Paragon Genomics is located in Fremont, CA, according to the details provided by the employer. Some roles may also include multiple work locations depending on the requirement.

What pay range can candidates expect for this role at Paragon Genomics?

Candidates can expect a pay range of $170,000 and $200,000 per year.

What employment applies to this position at Paragon Genomics?

Paragon Genomics lists this role as a Full-time position.

What experience level is required for this role at Paragon Genomics?

Paragon Genomics is looking for a candidate with "Director" experience level.

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