Executive Director, Head of Global Site Management

KardiganPrinceton, New Jersey

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Overview

Schedule

Full-time

Career level

Director

Benefits

Career Development

Job Description

About Us

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.

It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Giannakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

Role Summary

The Head of Global Site Management leads all site-facing clinical trial activities across the global development portfolio. This operational leadership role is responsible for Site Management & Monitoring and Clinical Trial Optimization & Strategic Partnership functions. This role provides strategic leadership for site start-up, site management, and monitoring to drive predictable execution, accelerate timelines, improve enrollment performance, ensure high-quality data, and establish strategic site partnerships.

As a member of the Clinical Operations senior leadership team, this role is also responsible for supporting strategic initiatives across the development organization.

Key Responsibilities

Build & lead global site management, monitoring, and study start-up activities across all clinical programs

Develop and execute site strategies to optimize selection, activation, enrollment, and retention

Establish consistent monitoring models, including risk-based monitoring approaches

Build and maintain strategic relationships with investigative sites, site networks, and partners

Partner closely with Clinical Operations, Clinical Development, Biometrics, and Development Services to ensure seamless, disciplined program and trial execution

Identify and mitigate site-level operational and quality risks

Establish scalable processes, metrics, and dashboards to track and improve site performance

Establish operating model inclusive of vendor strategy, oversight, risk management, key performance metrics, and dashboards

Provide expert insight into operational strategy plans (feasibility, monitoring strategies) and operating budgets

Create and continuously improve standard operating procedures, work instructions, to ensure inspection readiness

Participate in regulatory authority inspections, sponsor audits, and oversee site audits in partnership with Quality

Ensure compliance with GCP, regulatory requirements, and internal standards

Ability to assess and transform capabilities through AI and Automation solutions or strategies

Up to 20-30% domestic and international travel, as required.

Qualifications

Bachelor's degree in life sciences or related field

12+ years of experience in site management or clinical operations leadership

Or advanced degree (PhD, MBA, Masters) and 10+ yrs of experience

Deep expertise in global study start-up and enrollment optimization

Strong people leadership and stakeholder management skills

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FAQs About Executive Director, Head of Global Site Management Jobs at Kardigan

What is the work location for this position at Kardigan?

This job at Kardigan is located in Princeton, New Jersey, according to the details provided by the employer. Some roles may also include multiple work locations depending on the requirement.

What pay range can candidates expect for this role at Kardigan?

Employer has not shared pay details for this role.

What employment applies to this position at Kardigan?

Kardigan lists this role as a Full-time position.

What experience level is required for this role at Kardigan?

Kardigan is looking for a candidate with "Director" experience level.

What is the process to apply for this position at Kardigan?

You can apply for this role at Kardigan either through Sonara's automated application system, which helps you submit applications 10X faster with minimal effort, or by applying manually using the direct link on the job page.