Manager, Program Management

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1).

2026 represents a catalyst-rich period for Entrada. We expect multiple clinical data readouts as we advance several DMD programs across the U.K., EU, and U.S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670).

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are excited about the opportunity to contribute to the growth of the program management function here at Entrada. You live in the details and enjoy connecting the dots of complicated development plans, but you are also interested in the strategy and science those details support. You welcome the opportunity to wear many hats and deepen your knowledge across functions. You work successfully in a fast-paced team environment and have strong interpersonal skills. You are a proactive communicator and are always willing to assist your team members in their shared goal of transforming the lives of patients.

The Opportunity

The Manager, Program Manager (PM) will provide comprehensive program management support across multiple clinical development programs, ensuring alignment with cross‑functional strategic and operational objectives. Success requires exceptional attention to detail, strong forward‑planning and organizational capabilities, and the ability to effectively engage, influence, and manage stakeholders across diverse teams.

Responsibilities

• Provide program management support to multiple clinical development project/program teams.
• Develop and maintain detailed end-to-end integrated program timelines; track and monitor key interdependencies and milestones.
• Support development of program meeting agendas and outcomes; document and track actions and decisions.
• Collaborate with cross-functional teams to ensure alignment with company and program objectives.
• Identify and track program risks, issues, and dependencies; ensure communication and awareness across key stakeholders.
• Apply PM best practices and methodologies to contribute to the growth and development of the Program Management Team.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• BA/BS degree required, with 8+ years in clinical and drug development within the biotech/pharmaceutical industry, with 3+ years in clinical-stage project/program management.
• Strong understanding of drug development and how various functions integrate.
• Proficiency in project management software (MS Project) and experience with timeline visualization software (e.g. OnePager).
• Excellent organizational skills and attention to detail.
• The ability to work effectively across functions.
• Ability to manage multiple priorities in a fast-paced, dynamic environment.
• Excellent verbal and written communication skills.
• Desire to work in an innovative and collaborative environment.
• PMP preferred but not required.
• This is a US based remote position, with preference given to local New England based candidates. This role will require regular on-site presence at the Entrada Therapeutics Headquarters located in Boston, MA

What We Offer: Meaningful Work, Fair Rewards, and Real Support

At Entrada Therapeutics, we understand that compensation and total rewards are a major consideration when exploring a new opportunity. We believe in transparency and equity and are committed to sharing salary ranges for every position, along with insight into our compensation philosophy, in accordance with certain state requirements in the United States and fostering a fair and open environment at the onset.

But we also know it is more than just pay. When you join Entrada, you’ll be part of a mission-driven team with access to comprehensive health, dental and vision coverage; life and disability insurance; with a 401(k) match. We pride ourselves on offering competitive benefits that empower our employees and reflect the value of their contributions – offering paid, gender-inclusive parental leave, holistic support for your health and well-being, education reimbursement, discretionary time off and commuting benefits aligned to your working model. If you find yourself working from our office in Boston’s Seaport District, this puts you steps away from some of the best the city has to offer.

“Our approach to compensation is grounded in transparency, equity and performance for the unique contributions each person brings. At Entrada, we know that meaningful work deserves meaningful reward — and we view compensation as one way we show appreciation for the collaboration, curiosity and commitment that drive our mission forward.”

— Kerry Robert, SVP of People

The salary for this opportunity ranges from $127,000-$159,000. The final base compensation offered will depend on several considerations which include but may not be limited to a candidate’s skills, competencies, experience and other job-related factors permitted by law. The final salary offered may fall outside of this range.#LI-JF1 #LI-Remote

Equal Opportunity Employer

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. 

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Privacy Statement

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