Medical Director, Neurology Clinical Development

About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach.

Position Purpose:

The Medical Director Neurology Clinical Development will provide strategic leadership for planning, execution, and interpretation of clinical studies focused on transformative therapies for life-threatening neurological diseases. This individual will be responsible for leading study design and execution and driving interpretation of data to support development decisions across one or more programs.

The Medical Director will serve as a key leader within cross-functional teams and as an important representative of the program with investigators, consultants, and other key stakeholders. This role requires an experienced physician-drug developer who can operate with substantial independence, influence program direction, and ensure scientific and medical rigor from early development through late-stage studies. This role will report to the Vice President, Neurology Clinical Development.

Key Responsibilities:

Clinical Development & Execution

• Lead the clinical development strategy for assigned neurology programs, aligning study design and execution with overall program goals, target product profile, and regulatory path
• Provide medical leadership across the lifecycle of development, from early clinical planning through pivotal studies and submission-enabling activities
• Lead the design, review, and finalization of protocols, amendments, and other core clinical documents to ensure scientific rigor, feasibility, and strategic alignment
• Drive study-level data review, interpretation, and presentation to support timely and informed decision-making
• Identify development risks, anticipate clinical and operational challenges, and proactively propose mitigation strategies
• Maintain productive working relationships with CROs, investigators, and study site personnel to support enrollment, data quality, and protocol compliance

Clinical Oversight & Decision-Making and Scientific Contribution

• Provide medical oversight for ongoing studies, including medical monitoring strategy, safety review, protocol-related decisions, and clinical issue escalation
• Partner closely with safety/pharmacovigilance on signal assessment, benefit-risk evaluation, and safety governance
• Contribute to the development and refinement of Clinical Development Plans and related program materials
• Oversee the quality and consistency of medical input across study teams, vendors, and collaborators
• Ensure clinical development activities adherence to GCP, ICH, and applicable regulatory and ethical guidelines
• Integrate emerging data, literature, and competitive intelligence to inform ongoing program decisions and ensure scientific relevance and rigor
• Participate in internal discussions and presentations to communicate key scientific insights, data interpretations, and development updates
• Contribute to the preparation and review of strategic and regulatory documents, including target product profiles, clinical sections of IND/CTA submissions, and briefing packages

External Engagement & Communication

• Engage and collaborate with investigators, consultants, and key opinion leaders to support trial execution and scientific exchange
• Represent the clinical development organization at investigator meetings, advisory boards, and scientific congresses
• Contribute to the authorship of abstracts, manuscripts, and scientific presentations communicating clinical findings

Leadership & Collaboration

• Provide clinical and scientific leadership with cross-functional clinical teams, fostering an environment of accountability, curiosity, and collaborative problem solving
• Contribute meaningfully to governance discussions and development planning
• Provide strategic clinical input into regulatory strategy, submission planning, and lifecycle management activities

Required Skills & Experience:

• MD or MD/PhD candidates with relevant clinical development experience in neurology, rare/orphan, or genetic diseases
• Board certified or eligible in neurology, pediatrics, or a relevant specialty strongly preferred
• Minimum 6 years of relevant experience in biotech or pharmaceutical clinical development, including meaningful responsibility for design, conduct, and medical oversight of clinical trials
• Strong understanding of FDA/EMA regulations and ICH/GCP guidelines
• Strong scientific, analytical, and organizational skills
• Demonstrated ability to independently interpret complex clinical and scientific data and translate insights into development decisions
• Experience representing programs in cross-functional, partner, and/or regulatory interactions
• Strong leadership, communication, and influence skills in a matrixed environment
• High personal integrity, sound judgement, and strong commitment to advancing therapies for patients with serious neurological diseases

Location(s):

Stoke operates in Bedford, MA. This position is a hybrid position with an office setting based in our Bedford, MA location.

Travel:

This position will require approximately 20% travel (domestic and international).

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $269,000 - $331,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location.  In addition to base salary, Stoke offers an annual bonus and   equity participation.

Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. 

Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.