Postdoctoral Associate Human Microvascular Models And Extracellular Matrix Biology

JouléPittsburgh, PA

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Job Description

Title: Postdoctoral Associate, Human Microvascular Models and Extracellular Matrix BiologyLocation: Onsite, Pittsburgh, PA 15213Type: Direct-Hire/PermanentHours: Standard business hoursStart: MayOverview: We are looking for a highly motivated Postdoctoral Associate to join a lab focused on discovering novel therapeutics. This interdisciplinary program develops advanced in vitro models of hematopoietic and immune system function such as conducting research at the intersection of microphysiological systems (Organs-on-Chips) and immunology. The role emphasizes the use of microphysiological systems to model human microvascular structure and function within physiologically relevant three-dimensional microenvironments, with a particular focus on endothelial–stromal interactions, matrix remodeling, and tissue-level responses under dynamic conditions.Responsibilities:

Design and execute experimental studies using advanced in vitro microvascular and tissue-engineered systems, including endothelial and stromal cell components
Establish and maintain multicellular cultures within three-dimensional microenvironments to investigate vascular function and ECM remodeling
Perform and optimize assays to evaluate vascular integrity, permeability, inflammatory signaling, and matrix-related processes
Contribute to development and refinement of experimental workflows, including matrix composition, cell seeding strategies, and system reproducibility
Collaborate with multidisciplinary teams to integrate microvascular data with complementary model systems and analytical platforms
Maintain accurate and detailed documentation of experimental procedures and results
Analyze and interpret data, and contribute to preparation of manuscripts, reports, and grant applications
Mentor trainees and assist in training of laboratory personnel as needed

Requirements:

Ph.D. in Biomedical Engineering, Vascular Biology, Cell Biology, or a related field
Experience with primary human endothelial and stromal cell culture and/or multicellular in vitro systems
Background in extracellular matrix biology, tissue remodeling, or microenvironmental regulation
Strong experimental design, analytical, and problem-solving skills
Ability to work independently and collaboratively in a multidisciplinary research environment
Strong written and verbal communication skills

Preferred:

Experience with three-dimensional culture systems or Organs-on-Chips
Familiarity with assays for vascular permeability, matrix remodeling, or mechanobiology
Experience with imaging-based, biophysical, or quantitative molecular analyses
Experience working in interdisciplinary teams integrating biology and engineering

#M3 Ref: #558-Scientific

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