Research Scientist, Proteomics

Responsibilities and Duties

Corporate

• Follow SOPs and other applicable laboratory or company procedures

• Maintain confidential information consistent with Inotiv corporate policy

• Demonstrate Inotiv Core Values

General

• Interact with clients, other employees, and the community in a professional manner

• Support and participate in company initiatives

• Perform other duties as assigned

Specific

• Following the safety rules in the lab and maintaining a safe working environment.

• Operating lab equipment and performing analyses according to the Operation Manuals, SOPs, Best Practices, and training.

• Performing proteomic sample preparation in support of discovery and translational studies, including:

• Protein extraction and lysis, reduction and alkylation, and enzymatic (e.g., tryptic) digestion.

• Peptide cleanup and desalting (S-Trap, SP3, SPE) and protein/peptide quantification.

• Preparing buffers, reagents, and stock solutions, and verifying their composition.

• Preparing samples through LC-MS injection and assisting with data acquisition as instructed.

• Operating, programming, and maintaining automated liquid-handling and bead-based sample-preparation systems (e.g., KingFisher, Bravo) to support reproducible, plate-based, high-throughput proteomic processing.

• Recording results accurately in the ELN and contributing to data summaries and study documentation.

• Notifying the Lab Manager and/or Principal Investigator of any deviations from the study protocol/SOPs/Best Practices or unexpected processes preventing the proper completion of sample processing and documenting as required.

• Observing deadlines, producing timely results or communicating to management when deadlines cannot be accomplished.

• Performing assigned general lab tasks, including data logging, routine maintenance of equipment, and general housekeeping.

• Ordering reagents, parts and/or materials needed for the functioning of the Lab. Handling, inventorying and managing incoming materials and samples, waste and shipping of samples to outside parties when needed.

• Ensuring training files are properly maintained by keeping his/her CV current and for providing copies of certificates or documentation of training.

• Demonstrating an understanding of Best Practices and SOPs, and applying Good Laboratory Practice principles (21 CFR Part 58) where studies are conducted under regulatory requirements.

Position Requirements

Education and experience

• BS, or MS, or equivalent degree in Chemistry, Biochemistry, Biology, Molecular Biology, or related field with qualifying laboratory experience in degree program

Skills and abilities

• A basic understanding of processes related to Bioanalysis including sample preparation, instrument / equipment operation and data processing and reporting.

• Experience with analysis of proteins and peptides by mass spectrometry, including protein-specific extraction, separation, and purification methods (e.g., in-solution or on-bead digestion, S-Trap, SP3, and C18/SPE peptide desalting).

• Experience with, or aptitude to learn, automated sample-preparation platforms, such as the Thermo KingFisher (magnetic bead-based protein/peptide cleanup and SP3) and the Agilent Bravo / AssayMAP (automated liquid handling and cartridge-based peptide desalting).

• Comfort working with plate-based, high-throughput workflows (e.g., 96-well processing) and large sample cohorts.

• An attitude for quality, an eye for detail, the ability to follow written instructions and work effectively with management to complete assigned tasks.

• Documentation discipline and the ability to follow SOPs and written protocols precisely; familiarity with GLP/GMP/GCP principles is a plus.

• Ability to use a computer and an electronic lab notebook (ELN) to record experimental detail, and to compile and maintain databases for records and inventory, utilizing the appropriate software.

• A working knowledge and awareness of general laboratory procedures.

• Good written and oral communication skills.

• Ability to adhere to all safety regulations and procedures.

Desired:

• Experience with software for analysis of mass spectrometry data.

Performance Requirements

General

• Ability to read, write, speak and understand English

Physical Activity

• Moderate physical activity This position will require frequent walking, sitting and/or standing for extended periods of time, carrying, heavy lifting (max. 50 lbs), reaching while standing, gripping and twisting hand movements, finger control and other general repetitive motions (for more than four [4] hours per day)

• Able to wear latex or nitrile gloves, dust mask or respirator, and safety glasses as required.

• Ability to read and understand applicable materials

• Manual dexterity to operate laboratory equipment and calculator/computer

• Able to read and interpret test results and instrument specifications

Working Conditions

• Work is normally performed in a typical interior office work or laboratory environment

• Work environment involves exposure to potentially dangerous materials and situations that require following extensive safety precautions and may include use of protective equipment

• The noise level is usually moderate

• This position will frequently be involved with radiant/electrical energy, solvents, grease, oil, irritants, acids, bases, and other hazardous chemicals, electro-mechanical hazards, flammable materials and bio-hazards. Due to exposure to hazardous biological material (which may include HIV positive specimens), immunization to Hepatitis B and/or other diseases may be a requirement.

• This position could be offered at different levels for candidates who qualify with a combination of advanced levels of education and/or years of experience. The salary range will adjust along with the level of the role to match the person's relevant experience and/or education level.

Inotiv is a growing contemporary drug discovery and development company where we "Play to Win" in an industry rich with opportunity. Together, we face challenges and together we win in the delivery of world-class drug discovery and development solutions that impact the health and well-being of people all over the world. There's an opportunity for everyone at all phases of a career, each individual's unique skill set has an impact on the work we conduct. If you have the talent and desire to impact the quality of people's lives, we have the career opportunities to make it happen. Join us in embracing research and science to impact the health and well-being of people all over the world.

Salary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K, and more!

Inotiv is an Equal Opportunity Employer. It is our policy to provide a fair and equal employment opportunity to all persons, regardless of age, race, color, religion, sex, gender, gender identity, gender expression, sexual orientation, genetic information, disability, national origin, veteran status, or any other basis prohibited by law. This policy governs all aspects of employment, including selection, job assignment, compensation, discipline, termination and access to benefits and training.