Scientist / Senior Scientist, Molecular Biology
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Overview
Schedule
Full-time
Career level
Senior-level
Remote
On-site
Compensation
$115,000-$145,000/year
Benefits
Health Insurance
Dental Insurance
Vision Insurance
Job Description
SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.We are seeking a Scientist or Senior Scientist to lead the molecular biology function within our Cell Sciences team. This role serves as the molecular biology subject matter expert supporting cell line development, owning vector and construct design strategy and the nucleic acid analytics that underpin clone characterization. It is well suited to a scientist who combines deep hands-on molecular biology expertise with the judgment to design experimental strategy independently and the interest in developing junior scientific staff.This is a full-time onsite position in Bothell, WA.Responsibilities
- Lead the design and execution of molecular biology strategies supporting cell line development programs, including expression vector design, construct generation, and nucleic acid analytics for bi-specific and multi-specific antibodies and ADCs.
- Design mammalian expression vectors and cloning strategies for complex multi-chain and multi-specific antibody formats; evaluate and optimize vector architecture, regulatory elements, and selection systems to improve expression and product quality.
- Develop, qualify, and troubleshoot digital droplet PCR (ddPCR) assays for absolute nucleic acid quantification, including transgene copy number determination, and gene expression analysis in support of clone characterization and cell line stability assessment.
- Perform and oversee routine and high-throughput molecular biology workflows, including library preparation, PCR, restriction endonuclease digestion, Gibson Assembly, Golden Gate Assembly, bacterial transformations, and plasmid purification.
- Serve as the molecular biology subject matter expert to the Cell Line Development group, partnering with cell culture, protein sciences, and analytical teams to align construct design with expression, productivity, and developability objectives.
- Supervise, train, and develop 1–2 Research Associates; set experimental priorities, review data for scientific rigor, and ensure adherence to documentation standards.
- Evaluate and implement new molecular biology technologies, laboratory automation, and next-generation sequencing approaches to improve throughput, data quality, and program timelines.
- Analyze, interpret, and present experimental data to cross-functional teams and senior leadership; author technical reports, protocols, and sections of IND-enabling and regulatory documentation.
- Maintain detailed and reproducible records of experimental procedures and results in electronic lab notebooks.
- Manage multiple projects and shifting priorities simultaneously in a fast-paced, milestone-driven environment.
Qualifications
Compensation and Benefits:The expected base salary range for this position is $115,000 - $145,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.- Ph.D. in Molecular Biology, Cell Biology, Biochemistry, or a related field.
- Demonstrated expertise in molecular cloning and construct design, including PCR, Gibson Assembly, Golden Gate Assembly, restriction endonuclease digestion, bacterial transformation, and plasmid preparation.
- Hands-on experience developing and executing digital droplet PCR (ddPCR) and/or quantitative PCR (qPCR) assays, including assay design, optimization, and data analysis.
- Experience designing mammalian expression vectors for therapeutic proteins; experience with multi-specific antibody or ADC formats is strongly preferred.
- Working knowledge of cell line development workflows and an understanding of how construct design influences expression, productivity, and clone stability.
- Experience with next-generation sequencing workflows and data interpretation is a plus.
- Liquid handler and laboratory automation experience is a plus.
- Prior experience mentoring, training, or supervising junior scientific staff.
- Excellent written and verbal communication skills, with a track record of presenting data to cross-functional audiences.
- Strong organizational skills and attention to detail, with the ability to work both independently and as part of a collaborative team.
- Comfortable working in a dynamic environment with shifting priorities.
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FAQs About Scientist / Senior Scientist, Molecular Biology Jobs at Systimmune
What is the work location for this position at Systimmune?
This job at Systimmune is located in Bothell, WA, according to the details provided by the employer. Some roles may also include multiple work locations depending on the requirement.
What pay range can candidates expect for this role at Systimmune?
Candidates can expect a pay range of $115,000 and $145,000 per year.
What employment applies to this position at Systimmune?
Systimmune lists this role as a Full-time position.
What experience level is required for this role at Systimmune?
Systimmune is looking for a candidate with "Senior-level" experience level.
What benefits are offered by Systimmune for this role?
Systimmune offers following benefits: Health Insurance, Dental Insurance, Vision Insurance, Disability Insurance, Paid Holidays, Paid Vacation, Paid Sick Leave, 401k Matching/Retirement Savings, and Health & Wellness Programs for this position. Actual benefits may vary depending on the employer's policies and employment terms.
What is the process to apply for this position at Systimmune?
You can apply for this role at Systimmune either through Sonara's automated application system, which helps you submit applications 10X faster with minimal effort, or by applying manually using the direct link on the job page.