Scientist I, Assay Development In Vitro/In Vivo Pharmacology

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases.

Why Choose Editas?

At Editas Medicine, we're a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what's possible in medicine, come join us and become an Editor!

Decoding The Role:

Editas Medicine is seeking an accomplished Scientist to join our In Vivo Discovery Team to bolster our assay development group and support our pharmacology efforts. The Sci I will be integral to pipeline development by centralizing our molecular/biochemical assay development activities in support of existing targets, and spearheading research, onboarding and qualification of new assays to support new indications.

Characterizing Your Impact:

As Scientist I in the In Vivo Discovery Team, you will:

• Generate high quality and reproducible data that will allow us to conclusively determine whether a disease program will move forward to the next stage of development.
• Be an integral contributor to the evaluation of novel therapeutic targets and help expand Editas drug pipeline
• Design, optimize and qualify assays to quantify the functional impact of therapeutic gene editing in vivo and in vitro.
• Examine gene and protein expression in vivo and in vitro
• Complete timely experimental documentation and reports
• Demonstrate command of our standard lab techniques, instrumentation and software
• Show good organization and sharing of data at group meetings
• Demonstrate successful and independent troubleshooting of assay development
• Maintain mammalian cell cultures and contribute to the development of in vitro disease models

The Ideal Transcript:

To thrive in this role, you'll need:

Qualifications

• B.S. w/ 6+ years, M.S. w/ 4+ years of experience or Ph.D. in cell biology, molecular biology, bioengineering, or a related field
• Industry experience in molecular biology or a related field is highly desirable
• Extensive experience in biochemical and cell-based assay development including design, execution and qualification.
• Extensive experience in molecular and cell biology techniques: ELISA, Western blotting, MSD, flow cytometry, RT-ddPCR, quantitative PCR, biochemical/cell-based assays to measure metabolites and enzymatic activity (colorimetric, fluorometric and luminescence-based).
• Extensive experience in mammalian cell culture and transfections
• Experience working with CRISPR, non-viral (LNP) and/or viral (AAV, lentivirus) delivery vectors is a plus
• Familiarity with DNA analysis software such as VectorNTI, Geneious, Benchling is a plus

Fundamentals That Set You Apart

• Knowledge of genetic diseases, gene-editing and gene therapy
• Experience with in vitro or in vivo pharmacology and assay qualification
• Experience with primary hepatocytes and advanced in vitro hepatocyte culture such as 3D-organoid culture or liver-on-a-chip
• An ability to work in a dynamic, fast-paced, team-oriented, and multidisciplinary environment
• Self-motivated and results-driven with excellent attention to detail
• Ability to independently design, execute and evaluate protocols to drive assignments to completion
• Well-organized and excellent at multi-tasking

Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

Salary Range:

$132,000 - $145,000

Pay Transparency

Editas Medicine is committed to transparency and accuracy in our hiring practices. The anticipated salary range for each position is posted within the role. The final salary offer will be determined based on a comprehensive assessment of the candidate's qualifications, including education, training, and relevant experience. Additional factors such as external market conditions, the role's criticality, and internal equity will also be considered. Editas Medicine's compensation philosophy ensures fair and equitable pay practices.

Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.