Senior Director, Compliance Business Partner

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Madrigal Pharmaceuticals is seeking a Senior Director, Compliance Business Partner to support and enhance its global Compliance Program. This role will serve as a key advisor to business stakeholders, providing practical, risk-based compliance guidance across a range of commercial and other activities.

The Senior Director will partner cross-functionally to help ensure that business initiatives—including healthcare professional engagements, advisory boards, patient support programs, grants, and promotional and non-promotional activities—are executed in alignment with applicable laws, regulations, and company policies.

The ideal candidate will bring strong compliance and legal acumen, sound judgment, and the ability to translate complex regulatory requirements into actionable guidance in a fast-paced, evolving environment.

Position Responsibilities

The key responsibilities for this role include:

• Serve as a Compliance Business Partner to Commercial, Patient Advocacy, Patient Support Services, and other cross-functional stakeholders, providing proactive, risk-based guidance on business activities and strategic initiatives
• Provide compliance review and oversight of key activities, including healthcare professional engagements, advisory boards, needs assessments, internal and external meetings, patient support programs, and promotional and non-promotional materials
• Advise on business initiatives through the application of legal and compliance frameworks, including review of documentation and agreements in collaboration with Legal, as appropriate
• Support the development and delivery of compliance training and communications to promote awareness and understanding of compliance requirements
• Conduct third-party risk management activities, including due diligence, risk assessment, and ongoing oversight of vendors and partners
• Participate in governance activities, including grant committees and business reviews, providing compliance guidance to support appropriate decision-making
• Support compliance monitoring, risk assessment, and investigation activities, including identifying trends, assessing risk, and contributing to remediation efforts
• Contribute to the development and continuous improvement of compliance policies, procedures, and program infrastructure
• Communicate compliance risks, trends, and insights to leadership and relevant governance forums

Education & Experience

• Bachelor’s degree required; advanced degree (e.g., JD, MBA, or CPA) and/or Paralegal certification or equivalent legal training/experience preferred
• 12+ years of pharmaceutical or life sciences compliance experience
• Demonstrated experience supporting commercial and/or other functions in a compliance business partner capacity
• Strong knowledge of healthcare laws, regulations, and industry codes

Preferred Qualifications

• Experience supporting healthcare professional engagements, advisory boards, and patient support programs
• Experience with third-party risk management and compliance due diligence
• Prior experience in a business-facing compliance role within a biopharmaceutical company
• Ability to interpret and apply regulatory requirements in a practical, business-oriented manner

Key Competencies

• Strong judgment and ability to balance compliance risk with business objectives
• Excellent communication and stakeholder management skills
• Ability to operate effectively in a fast-paced, cross-functional environment
• Collaborative, solutions-oriented approach to business partnering
• High level of integrity, professionalism, and accountability
• Strong analytical skills with attention to detail
• Ability to manage multiple priorities and deliver high-quality work under tight timelines
• Positive, adaptable approach with a sense of perspective and humor

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands.  As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $254,000 - $311,000 per year.  We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. 

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.