Senior Engineer I, Science

Here at Ginkgo, we are aiming to modernize ADME by bringing our experience in high-throughput screening to the in vitro small molecule drug pipeline. We are re-imagining ADME at scale, and we are seeking a visionary and technically adept High-Throughput ADME Scientist to help us build and execute this next-generation platform. This role is critical in accelerating our drug discovery pipeline by providing timely and high-quality in vitro ADME (Absorption, Distribution, Metabolism, and Excretion) data to guide lead optimization.

The ideal candidate will possess deep technical expertise in developing, validating, and implementing a variety of high-throughput ADME assays.

Key Responsibilities

Assay Development & Implementation

• Design, develop, optimize, and validate a wide array of high-throughput in vitro ADME assays (e.g., solubility, MDCK permeability, plasma protein binding, microsomal stability, hepatocyte stability, and CYP inhibition/induction).
• Automation and Screening: Experience working with automated liquid handlers such as Hamilton, Lynx, Bravo, and Formulatrix.

Data Analysis & Reporting

• Develop and perform mass spectrometry (LC-MS/MS, acoustic ejection mass spectrometry, or similar) analysis of samples from ADME assays. Responsibilities will include method development and troubleshooting.
• Ensure proper sample preparation and management for high-throughput analysis.
• Analyze, interpret, and report complex ADME data, including calculating key pharmacokinetic parameters.
• Present results and provide expert recommendations to medicinal chemists and project teams to inform go/no-go decisions.

Quality & Compliance

• Maintain detailed and accurate laboratory records, SOPs, and electronic notebooks.
• Ensure all laboratory activities comply with internal quality standards and safety regulations.

Minimum Qualifications

• Education: Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or a related field with 2+ years of relevant industry experience, or a Master's degree with 5+ years of industry experience.
• Technical Expertise:
• Extensive, hands-on experience with LC-MS or acoustic MS particularly in a high-throughput setting.
• Proven track record in developing and running automated in vitro ADME assays using state-of-the-art laboratory automation.
• Strong theoretical and practical knowledge of drug metabolism pathways and DMPK.
• Familiarity with common ADME prediction software and data visualization tools.

Preferred Skills

• Experience using lab automation.
• Programmatic coding experience (e.g., Python, R, or similar).
• Data visualization (Spotfire, Python, R, or similar).
• Experience handling clinical samples.
• Familiarity with working in a CRO (Contract Research Organization) environment or managing CRO relationships.
• Proficiency with electronic laboratory data capture systems (e.g., LIMS, ELN).

The base salary range for this role is $115,000.00 - $165,000.00. Actual pay within this range will depend on a candidate's skills, expertise, and experience. We also offer company stock awards, a comprehensive benefits package including medical, dental & vision coverage, health spending accounts, voluntary benefits, leave of absence policies, 401(k) program with employer contribution, 8 paid holidays in addition to a full-week winter shutdown and unlimited Paid Time Off policy.

Ginkgo has implemented a return to office policy effective October 1, 2025 with required in-office days: Tuesday, Wednesday, Thursday. This policy applies to all employees who live within 50 miles of Ginkgo's offices in Boston, MA, Emeryville, CA and West Sacramento, CA. Biosecurity positions are excluded from this policy.