Senior Scientist, Oligonucleotide Design And Chemistry

Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline. Overview: We are seeking a talented and dynamic individual with extensive oligonucleotide experience to join our team as a Scientist/Senior Scientist. This role offers a significant opportunity to impact our science and pipeline by leading the design and synthesis of novel oligonucleotides for drug discovery programs. The successful candidate will be a technical leader, guiding a dedicated team and taking on responsibilities across the portfolio. Key requirements include:

• Extensive hands-on experience in the synthesis, purification, and analytics of siRNA and/or ASO therapeutics.*
• In-depth knowledge of oligonucleotide/peptide therapeutics, including chemical structure search tools, synthesis techniques, purification instrumentation, and analysis methods for chemically modified oligonucleotides.*
• Demonstrated ability to both lead and support multiple parallel projects and thrive in highly collaborative team environments.

Key Responsibilities:

• Lead the design, synthesis, and characterization of novel oligonucleotides for various portfolio programs.*
• Provide mentorship to junior scientists in the synthesis and characterization of new oligonucleotide sequences.*
• Serve as a leader or active participant in cross-disciplinary discussions to ensure effective execution of portfolio programs.*
• Collaborate with biology and biochemistry teams to design and execute novel assays, facilitating rapid go/no-go decisions.*
• Take a leading role in managing all aspects of laboratory instrumentation and maintaining smooth operations.*
• Maintain a strong collaborative mindset and demonstrate excellent written and verbal communication skills.