Sr. Technical Program Manager

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company's platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location. Reporting directly or operationally into the VP, Clinical Operations, the role supports the broader coordination of efforts across teams to ensure impactful contributions to AI integration

Position Summary:

Structure Therapeutics is seeking a Sr. Technical Project / Program Manager to lead a portfolio of high-impact IT initiatives spanning R&D, G&A, and AI/Infrastructure platforms. This role is critical to enabling scientific innovation and enterprise scale by delivering complex, cross-functional programs with precision, transparency, and speed.

Operating at the level expected in leading biotech organizations, this individual will drive end-to-end program execution, establish strong delivery governance, and ensure alignment between scientific, corporate, and technology priorities. This role requires a balance of deep program management discipline, technical fluency, and AI-forward thinking, with a strong focus on execution excellence and executive communication.

Job Responsibilities:

Program & Project Leadership

• Lead end-to-end delivery of complex IT programs across:

• R&D systems (Clinical, Discovery, Preclinical)

• G&A systems (Finance, HR, Legal, collaboration tools)

• AI/ML and infrastructure platforms

• Drive program planning, execution, and delivery across the full Software Development Lifecycle (SDLC)

• Manage multiple concurrent initiatives with clear prioritization, resource alignment, and delivery accountability

• Ensure delivery within scope, timeline, budget, and quality expectations

Delivery Methodology & Execution Excellence

• Apply strong expertise in Agile, Waterfall, and hybrid delivery models, selecting the right approach based on program needs
• Establish structured project plans, milestones, and dependencies across technical and business teams
• Proactively manage risks, issues, and interdependencies with a solutions-oriented mindset
• Drive continuous improvement in delivery frameworks, tools, and operational rigor

Cross-Functional IT & Business Partnership

• Work closely with IT functions including Security, Infrastructure, Applications, Data/AI, and Enterprise Systems
• Partner with business stakeholders across R&D and G&A to define requirements, align priorities, and drive adoption
• Serve as the connective layer between engineering, architecture, and business teams to ensure cohesive execution
• Coordinate internal teams and external vendors/partners

Executive Reporting & Governance

• Own program governance, including steering committees, status reporting, and executive updates
• Deliver clear, concise, and data-driven reporting on program health, risks, and outcomes
• Translate complex technical initiatives into business-relevant insights for senior leadership
• Drive decision-making through structured communication and escalation management

AI & Digital Enablement

• Lead and support initiatives involving AI/ML platforms, data infrastructure, and automation
• Demonstrate AI literacy, leveraging modern AI tools to improve productivity and delivery outcomes
• Partner with data and engineering teams to enable scalable, production-ready AI solutions

PMO & Operational Leadership

• Contribute to building and scaling IT PMO capabilities, standards, and best practices
• Champion consistency in project execution, documentation, and reporting
• Mentor junior team members and promote a culture of accountability and continuous improvement

Qualifications:

Experience

• 7+ years of experience in technical project/program management, preferably within biotech, pharma, or regulated environments
• Proven success delivering complex, cross-functional IT programs supporting R&D and enterprise functions
• Experience working in environments comparable to other biopharma
• Strong track record of managing enterprise-scale initiatives and executive stakeholders

Technical & Delivery Expertise

• Strong understanding of:

• Software Development Lifecycle (SDLC)

• Agile, Waterfall, and hybrid delivery models

• Cloud infrastructure (AWS/Azure/GCP)

• Data platforms and AI/ML ecosystems

• Enterprise applications (Finance, HR, collaboration tools)

• Familiarity with GxP, validation, and compliance requirements is a plus.

Leadership & Communication

• Exceptional skills in project management, prioritization, and execution discipline
• Strong experience with executive reporting and stakeholder communication
• Ability to influence without authority and drive alignment across diverse teams
• High degree of ownership, accountability, and attention to detail

AI & Modern Tooling

• Demonstrated AI literacy, including practical use of AI tools to enhance productivity, reporting, or delivery workflows
• Interest in applying emerging technologies to improve IT and business outcomes

Education & Certifications

• Bachelor's degree in Computer Science, Engineering, or related field (Master's preferred)
• PMP, PgMP, Scrum, or equivalent certification preferred

Success Measures

• Consistent delivery of programs on time, within scope, and aligned to business outcomes
• High-quality executive visibility and reporting across IT initiatives
• Strong stakeholder satisfaction across R&D, G&A, and IT leadership
• Improved delivery maturity, standardization, and PMO effectiveness
• Successful enablement and adoption of AI and digital initiatives

Travel Required:

Occasional travel may be required based on business needs.

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $147,000 - $190,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate's geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance-based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.

Notice to Recruiters/Staffing Agencies

Recruiters and staffing agencies should not contact Structure Therapeutics through this page. All recruitment vendors (search firms, recruitment agencies, and staffing companies) are prohibited from contacting our hiring manager(s), executive team members, or employees.

We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.

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