Translational Medicine/ Biomarker Lead
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Overview
Schedule
Full-time
Career level
Director
Remote
Hybrid remote
Compensation
$217,000-$235,000/year
Benefits
Career Development
Job Description
Location: Needham, MA - HybridSalary: $217,000-$235,000Please Note: Applicants must be legally authorized to work in the United States. Sponsorship for employment visas is not available.Why Work With Us?At Candel, our people drive our success. We value diversity, collaboration, and bold thinking in a supportive, mission-driven environment. Like a team, we show up for each other and stay focused on making a difference for patients and families. Our leadership is transparent and empowering, and our culture is built on trust, flexibility, and accountability, encouraging ownership and innovation every day. Our Science: Advancing Cancer Immunotherapies Candel is a clinical-stage biopharma company developing off-the-shelf, multimodal immunotherapies that stimulate personalized, systemic anti-tumor responses. Our platforms use genetically modified adenovirus and HSV constructs. With positive Phase 3 results for our lead candidate, it’s an exciting time to join us and help bring transformative cancer treatments to patients. Learn more: www.candeltx.comPosition Summary: We are seeking an accomplished scientific leader in Translational Immunology to drive the strategic vision and cross-functional execution of our clinical biomarker programs. This is a critical leadership role ideal for a candidate with deep expertise in cancer immunology, immunology, translational science, and biomarker development, coupled with the ability to integrate complex biological and clinical datasets to inform key program decisions.As Head of Translational Medicine, you will be a central figure in advancing both early- and late-stage clinical programs, including pivotal contributions to a Biologics License Application (BLA) for our lead immunotherapy candidate.Reporting Structure:You will report directly to the Chief Scientific Officer and collaborate closely with the Vice President of Clinical Development and the Senior Manager of Translational Medicine to shape and accelerate our immuno-oncology strategy.Key ResponsibilitiesStrategic Leadership
- Develop and implement scientific strategies for analyses across clinical and preclinical studies.
- Provide expert guidance on emerging developments in immunology and oncology to inform target selection and mechanism-of-action insights.
- Lead cross-functional governance initiatives and external collaborations to support regulatory strategy and clinical development goals.
- Design and oversee execution of bio-sampling and biomarker strategies to identify mechanisms of response and resistance.
- Integrate exploratory endpoints and novel assay technologies into clinical trial designs.
- Analyze and interpret complex biomarker and clinical pharmacology data to inform patient selection and trial design.
- Contribute to the development of integrated clinical pharmacology packages and high-quality clinical protocols and regulatory submissions.
- Collaborate closely with internal stakeholders across Clinical Development, Research, Clinical Operations, QA and Regulatory Affairs
- Engage and manage external partners, academic collaborators, and CROs to enable timely and innovative translational research.
- Participate in scientific due diligence, regulatory meetings, and interactions as needed.
- PhD in Immunology, Molecular Biology, Genetics, or a related field, or MD with relevant post-doctoral training.
- 5+ years of experience in translational science, ideally within oncology or immuno-oncology programs.
- Strong track record of contributing to and leading oncology clinical trials; experience with regulatory submissions and filings preferred.
- Deep expertise in biomarker development, assay platforms, and integration of translational endpoints into clinical trial designs.
- Working knowledge of GLP, GCP, and regulatory standards relevant to biomarker and clinical trial execution.
- Demonstrated ability to lead cross-functional teams and manage complex scientific projects in biotech or pharma settings.
- Excellent communication, scientific presentation, and strategic thinking skills.
- Proficiency with bioinformatics tools and data visualization platforms for biomarker data analysis.
- Experience managing biomarker-driven immuno-oncology trials, including immune monitoring and pharmacodynamics.
- Proven ability to manage multiple priorities in a fast-paced, dynamic environment.
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FAQs About Translational Medicine/ Biomarker Lead Jobs at Candel Therapeutics
What is the work location for this position at Candel Therapeutics?
This job at Candel Therapeutics is located in Needham, MA, according to the details provided by the employer. Some roles may also include multiple work locations depending on the requirement.
What pay range can candidates expect for this role at Candel Therapeutics?
Candidates can expect a pay range of $217,000 and $235,000 per year.
What employment applies to this position at Candel Therapeutics?
Candel Therapeutics lists this role as a Full-time position.
What experience level is required for this role at Candel Therapeutics?
Candel Therapeutics is looking for a candidate with "Director" experience level.
What is the process to apply for this position at Candel Therapeutics?
You can apply for this role at Candel Therapeutics either through Sonara's automated application system, which helps you submit applications 10X faster with minimal effort, or by applying manually using the direct link on the job page.