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Blueprint Medicines Corporation logo
Blueprint Medicines CorporationCambridge, MA
How will your role help us transform hope into reality? Research, identify, and validate novel oncology targets and small molecule drug discovery, utilizing knowledge of bioengineering to develop and conduct cellular assays to support Blueprint Medicine's novel drug discovery efforts. What will you do? Manages and QC routines assays performed at CRO and upload data to our server. (15%) Optimize and employ cellular and molecular assays such as Western blotting, Elisa and immunofluorescence-based assays to elucidate mechanistic biology of potential drug targets and mechanism of action of small molecules. (20%) Present research findings at team meetings. (5%) Maintain our automation platform and is the point of contact with the vendor when needed (such as major issues to be fixed or implementation of new updates). (15%) Design and development of automation methods for biological assays for several projects. Teach colleagues how to use those methods and troubleshoot when necessary. (15%) Cell culture Maintenance. (10%) Run routine assays when needed. (10%) Maintain detailed and critical experimental data records that are published in ELN according to industry compliance. (10%) What minimum qualifications do we require? Master's degree in Bioengineering, Biomedical Engineering, or a closely related biological or life sciences field (or foreign equivalent degree), plus 1 year of experience in biological research for oncology drug development. Experience, which may be gained concurrently, must include: 1 year of experience in maintaining, expanding, and freezing cell lines. 1 year of experience with running routine assays such as Alphalisa pERK and proliferation assays. 1 year of experience in using and programming liquid handlers such as Bravo, Biomek, Integra Assist Plus and D300. 1 year of experience in analyzing cell research data and presenting it to the team. 1 year of experience in analyzing and presenting scientific research papers. 1 year of experience in maintaining detailed ELN to ensure data reproducibility. This position is part of Blueprint Medicines' employee referral program and is eligible for an employee referral incentive bonus. Why Blueprint? At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators - the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success. This is the place where the extraordinary becomes reality, and you could be part of it. Patients are waiting. Are you ready to make the leap? Equal Employment Opportunity At Blueprint Medicines, we foster an environment of fair treatment and full participation for all of our employees as we navigate complex challenges in pursuing our mission to improve the lives of patients. We celebrate our unique differences and varied career and life experiences so that we can sustain our diverse culture and ensure everyone feels accepted. We are committed to non-discrimination, equal employment opportunity, as well as an inclusive recruitment process. We consider all qualified applicants based on merit and without regard to race, color, sex, gender identity, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable federal or state law. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com. We are also an E-Verify Employer. For more information, please see our EEO Policy Statement, the E-Verify Participation Poster, the Right to Work Poster, and the EEO Know Your Rights Poster. Blueprint Medicines, a Sanofi company, is a global biopharmaceutical company that invents life-changing medicines. We seek to improve and extend patients' lives by solving important medical problems, with a focus on allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a track record of success with two approved medicines, including AYVAKIT/AYVAKYT (avapritinib) which we are bringing to patients with SM in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases and solid tumors. For more information, visit www.BlueprintMedicines.com and follow us on X (formerly Twitter; @BlueprintMeds) and LinkedIn. Requisition #: 25-604 #LI-DNI

Posted 2 weeks ago

Loyola Marymount University logo
Loyola Marymount UniversityWestchester, CA
Loyola Marymount University's Frank R. Seaver College of Science and Engineering is collecting resumes of potential applicants for future Part-Time faculty positions in the Department of Biology. There may not be openings at this time, but your application will be kept on file. Current applications will be reviewed as openings occur. The position, when needed, is assumed to be a one-semester appointment, normally to teach 1-2 courses. The Department of Biology serves approximately 250 undergraduate majors. Additional information about the department, curriculum, courses, and faculty/staff is available online at http://cse.lmu.edu/department/biology/ . Openings most commonly available are to teach courses in General Biology, introductory Cell Biology, upper division courses in Microbiology or Genetics, and non-majors courses in Environmental Biology and areas of Human Biology. Job Responsibilities The following is a non-exhaustive list of instructor job responsibilities: prepare and distribute a course syllabus; prepare and lead class sessions; hold regular office hours and answer student questions; develop, distribute, and/or grade assignments, quizzes, and other course materials; write, proctor, and grade midterm and final examinations; maintain and submit in a timely manner class records, such as attendance and grade reports; attend meetings and training, as needed; and comply with all university standards and requirements. Minimum Qualifications Prior teaching experience is preferable. Position requires excellent oral and written communication and interpersonal skills. Must be committed to excellence in teaching our diverse student population and to work to promote equitable and inclusive classrooms and collaboration spaces. Required Education A doctorate level degree Special Instructions: Apply online at https://jobs.lmu.edu . A completed application consists of: A current CV/resume Cover Letter Statement of Teaching References - 2 references required Minimum salary is $2,467 per unit taught. Faculty Regular Loyola Marymount University, a Carnegie classified R2 institution in the mainstream of American Catholic higher education, seeks outstanding applicants who value its mission and share its commitment to inclusive excellence, the education of the whole person, and the building of a just society. LMU is an equal opportunity employer committed to providing an environment free from discrimination and harassment as defined by federal, state and local law. We invite all persons in the full diversity of their being, life experience, and beliefs to apply. (Visit www.lmu.edu for more information.)

Posted 30+ days ago

Vertex Pharmaceuticals, Inc logo
Vertex Pharmaceuticals, IncSan Diego, CA
Job Description Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases - cystic fibrosis, pain, sickle cell disease and transfusion-dependent beta thalassemia - and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases. The Senior Director - Protein Sciences and Structural Biology, will further develop our research efforts in structural biology, and biophysics. This role will be on-site in our state-of-the-art research site in San Diego. Expertise in structural biology and various biophysical techniques will be instrumental in guiding our drug discovery programs and providing key molecular insights for the advancement of novel therapeutics. This person will lead a team of structural biologists to elucidate high-resolution three-dimensional structures of critical targets, key protein-ligand and protein-protein interactions, and molecular mechanisms of action of our therapeutic approaches. He/she applies superior acumen in identifying project needs that are bolstered by refined, systematic creativity and strong judgment of when to launch efforts on a new trajectory. KEY RESPONSIBILITIES Lead and manage a team specialized in structural biology and biophysics. Provide guidance and mentorship. Foster a collaborative work environment. Develop and implement strategic plans to leverage structural biology and biophysics approaches for target identification, validation, mechanism of action studies, and drug discovery. Champion existing and new structural biology and biophysical technologies that advance drug discovery projects forward. Propose new applications, apply technology, and follow up on new MoA, drug target and binding site identification and/or kinetic analysis of drug binding. Collaborate with cross-functional teams, including medicinal chemists, computational scientists, and cellular biologists, to drive integrated drug discovery projects from target selection to lead optimization and delivery of clinical candidates. Independently perform hands-on experimental troubleshooting and methods development in biophysical assay development and protein structure determination by crystallography and/or CryoEM. Stay current with the latest advancements in the field of structural biology and biophysics, and integrate new technologies and methodologies into the drug discovery process. Propose and implement novel and improved data analysis tools. Maintain the excellence of standards for structure and interpretation of all laboratory records, electronic database entries, internal reports, patents, and external communications from the team. Ensure compliance with relevant regulatory guidelines, maintain accurate records, and promote a culture of scientific rigor and integrity within the team. Required Education Level Ph.D. (or equivalent degree) in Structural Biology, Biophysics, or a related field and 11+ years of industry / academic experience with a minimum of 5 years managing a team. Master's degree (or equivalent degree) and 15+ years of relevant employment experience, or Bachelor's Degree (or equivalent degree) and 20+ years of relevant employment experience. Extensive experience in pharmaceutical, biotechnology, or leading academic biomedical research setting, with a proven track record of leading and managing teams in structural biology and biophysics. Experience in applying structural biology and biophysics to advance drug discovery programs. Required Knowledge/Skills Established reputation with a strong track record of scientific impact in driving drug discovery programs forward by initiating and implementing structural biology and biophysics for mechanism-of-action studies and drug target or protein binding site identification and characterization. Experience can come from functional or cross-functional project leadership roles. Industry experience is preferred. Experience with integral membrane proteins is highly desirable. Experience in managing scientific teams, individual and team performance, goal setting, and career growth development and building a culture of innovation and inclusion. Demonstrated independent thought/creativity in science, leadership skills, and ability to inspire and motivate drug discovery teams. Excellent communication (oral and written) in articulating goals, objectives and results to the group and larger cross-functional project teams. Strong inter-personal, oral, and written communication skills. Extensive experience interfacing with internal and external stakeholders to collaborate and execute on research programs, deliver results, and influence decision making. Ability to navigate and be successful in a fast-paced, innovative, and multi-disciplinary work environment. #LI-SV1 #LI-Onsite Pay Range: $221,900 - $332,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Posted 30+ days ago

N logo
Nelson UniversityPhoenix, Arizona
Nelson American Indian College in Phoenix, Arizona is currently taking applications for Adjunct Professor Positions in Biology/Physical Science. Nelson AIC is affiliated and in partnership with Nelson University in Waxahachie, Texas. We are an Assemblies of God institution and all applicants must be willing to subscribe to a statement of faith for final consideration in addition to professional and academic requirements. Education All instructors must hold a master's degree + 18 hours in the area they are applying to teach in. Exception: Developmental instructors must hold a BA or higher in any area. Availability Needed for Fall 2024 semester. Compensation Salary based on level of course and students registered for course. How to Apply Submit a complete application package online at www.nelson.edu/employment , by completing the fields to the right of this screen under “Apply here”. These fields contain intake information. After clicking submit application, you will be taken to the Nelson Employment Application, where you will be asked to list references and previous employment positions. Once we've reviewed your application and resume and determine that you will be moving to the next step of the process, we'll reach out to request the following items: 1. Copies of transcripts from all higher education institutions (must be from a regionally accredited school). During preliminary interviews, we may photocopy these transcripts. However, as your candidacy formalizes, we'll need official transcripts. 2. A 3-5 page excerpt of a paper you completed for any graduate-level work. 3. A written expression of your philosophy of Christian Higher Education. 4. Two letters of reference, including one pastoral reference, if available. (E.g. If you attend a mega church, you may or may not know the senior pastor, so it is acceptable to ask any minister familiar with your faith to write a letter of reference for you.) 5. Completion of the Faculty Application Survey: Faith and Mission Alignment document Employment Classification: This position is exempt under the Fair Labor Standards Act.Nelson University is an equal opportunity employer committed to fostering a diverse academic community within our faith-based environment. Contact Dr. Carl Vanderpool, Administrative Dean – (602) 944-3335, cvanderpool@nelson.edu Nelson University (formerly Southwestern Assemblies of God University) is a vibrant, private Christian university located just 30 minutes south of the Dallas/Fort Worth Metroplex in Waxahachie. Founded in 1927, the university now offers over 70 associate, bachelor’s, master’s, and doctoral degrees, available on campus and online. As an evangelical Christian institution rooted in Biblical truth, Nelson University fosters a Spirit-empowered community where faculty, staff, and students are encouraged to live out their faith with purpose and integrity. We are passionate about equipping our team members to make a meaningful impact in both personal and professional spheres, embodying values that inspire and transform. Company website: www.nelson.edu

Posted 2 days ago

Goodfire logo
GoodfireSan Francisco, California
About Goodfire Behind our name: Like fire, AI holds the potential for both immense benefit and significant risk. Just as mastering fire transformed human history, we believe the safe and intentional development of AI will shape the future of our species. Our goal is to tame this new fire.Goodfire is an AI interpretability research company focused on understanding and intentionally designing advanced AI systems. We believe advances in interpretability will unlock the next frontier of safe and powerful foundation models and that deep research breakthroughs are necessary to make this possible.Everything we do is in service of that mission. We move fast, take ownership, and constantly push to improve. We believe in acting today rather than tomorrow. We care deeply about the success of the organization and put the team above ourselves.Goodfire is a public benefit corporation headquartered in San Francisco with a team of the world’s top interpretability researchers and engineers from organizations like OpenAI and DeepMind. We’ve raised $57M from investors like Menlo, Lightspeed and Anthropic and work with customers including Arc Institute, Mayo Clinic, and Rakuten. The role: Scientific AI models trained to model natural systems are revolutionizing research across scientific domains, including protein interaction prediction, protein design, disease prediction, and materials discovery. We’re looking for a Forward Deployed Research Scientist (Biology) to join our team to work directly with customers to develop new techniques for understanding and designing large biological foundation models. You’ll work closely with a small, mission-driven team of scientists and engineers to conduct novel research, build practical tools, and push the field forward. Where you'll contribute: Forward deployed research – lead scientific research with our partners to interpret advanced biological foundation models (genomic foundation models, ViTs, PLMs) to uncover what they’ve learned. Project delivery and implementation – own research delivery on high-stakes projects with customers and do whatever it takes to make delivery successful, including: problem and hypothesis definition, data sourcing, tool building, iteration, and implementation. Translate research into tools for real-world applications in precision medicine, digital pathology, drug discovery, and more. Core responsibilities: Work directly with customers to conduct original research in interpretability and computational biology. Prototype techniques to visualize and manipulate internal model structures. Collaborate with engineering to turn research into production-ready tools. Drive partnership success by collaborating closely with our customers and partners. Help define and evolve our research direction. Who you are: Goodfire is looking for experienced individuals who embody our values and share our deep commitment to making interpretability accessible. We care deeply about building a team who shares our values: Put mission and team first All we do is in service of our mission. We trust each other, deeply care about the success of the organization, and choose to put our team above ourselves. Improve constantly We are constantly looking to improve every piece of the business. We proactively critique ourselves and others in a kind and thoughtful way that translates to practical improvements in the organization. We are pragmatic and consistently implement the obvious fixes that work. Take ownership and initiative There are no bystanders here. We proactively identify problems and take full responsibility over getting a strong result. We are self-driven, own our mistakes, and feel deep responsibility over what we’re building. Action today We have a small amount of time to do something incredibly hard and meaningful. The pace and intensity of the organization is high. If we can take action today or tomorrow, we will choose to do it today. If you share our values and have at least two years of relevant experience, we encourage you to apply and join us in shaping the future of how we design AI systems. What we are looking for: PhD/MD or equivalent experience in biology, with a strong ML background and experience in computational biology or bioinformatics. Deep familiarity with large models and a passion for understanding how they work. Fluency in Python and ML frameworks such as PyTorch. Strong writing and communication skills for explaining complex ideas. Drive to move quickly and take ownership. Preferred qualifications: Experience leading research in a forward deployed environment and in service of a customer’s requirements. Familiarity with interpretability, alignment, or safe model development. Experience in startup or fast-paced lab environments. This role offers market competitive salary, equity, and competitive benefits. More importantly, you'll have the opportunity to work on groundbreaking technology with a world-class team dedicated to ensuring a safe and beneficial future for humanity. The expected salary range for this position is $220,000 - $315,000 USD.

Posted 2 weeks ago

Bryant & Stratton College logo
Bryant & Stratton CollegeAlbany, NY
Unlock your full potential in the innovative and inclusive environment at Bryant & Stratton College. We are a career-focused, private, nonprofit college built differently to serve the needs of students, alumni, associates, employers, and the community. Founded in 1854, Bryant & Stratton College offers real-world education leading to bachelor's, associate's, and professional certificates after completion in the fields of healthcare, technology, legal, business, graphic design, and more. Bryant & Stratton College faculty support the college mission by facilitating a Blended Learning Model through engaging classroom activities supplemented by comprehensive course content that are consistent with the Community of Inquiry framework, Seven Principles of Good Practice and Bloom's Taxonomy while adhering to the college's Rigor Standards Framework. Faculty are subject matter experts in their respective fields grounded in a high level of skill and ability which are the catalyst to managing their classroom responsibilities. Faculty are offered extensive training and development in teaching strategies and are expected to participate in departmental and campus wide activities to support the needs of the students in meeting their learning outcomes. Adjunct Professor-Biology MINIMUM QUALIFICATIONS Degree Requirements: Master's Degree in Biology required. Work Experience Requirements: Experience working in Biology field ESSENTIAL POSITION RESPONSIBILITIES/FUNCTIONS Provide instruction with the focus on teaching and learning to help assure students I each class successfully meet all course outcomes and classroom objectives. Participate in professional development activities that develop and enhance teaching and facilitation skills. Participate in campus wide initiatives in support of recruitment, retention and graduation goal attainment including but not limited to, monitoring, adjusting (when needed), and assessing classroom program retention/graduation and meeting with program advisors on a regular basis to discuss student performance and academic concerns. Fulfill all administrative duties related to instructional responsibilities Interested in teaching but are not sure it's for you? Observe a class and meet one-on-one with a faculty member to learn more about this amazing, life-changing opportunity. Apply today! Salary: $45 - $65 per hour based on credentials and experience Please note that the compensation information is a good faith estimate of the base pay for this position. Information about the total compensation package for this position will be provided during the interview process. All qualified applicants will receive consideration for employment without regard to age, race, ethnicity, national origin, color, religion, disability, marital status, veteran status, sex/gender (including pregnancy or pregnancy related conditions), sexual orientation, gender identity (including transgender status) or any other legally protected characteristics ("protected characteristics"). Bryant & Stratton College is an Equal Opportunity Employer.

Posted 30+ days ago

Eli Lilly and Company logo
Eli Lilly and CompanyPasadena, TX
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. The Protomer team at Lilly focuses on chemical biology, molecular switches and (oral) peptidic macrocycles platforms. This position is focused on deep technology development in chemical biology, specifically peptides and macrocycles with a particular focus on peptide libraries, and oral macrocyclic peptides. The Protomer team engages in disease-relevant biological systems in order to test preclinical and clinical pipeline of innovative medicines. The candidate is expected to help develop strategy, direction and manage scientific group milestones and objectives based on an ambitious long-term strategic plan which the candidate helps to develop. The ideal candidate is a significant contributor and leading a highly integrated, agile, and collaborative team effort and expected to manage the scientific portfolio, the business supporting the portfolio, and mentoring of junior scientists within the oral macrocycles group at Protomer. Ideal candidate is expected to have demonstrated success in similar roles with proven track record of leading both scientific rationale, planning and execution leading to success in making medicines. This individual will also be expected to be able to independently lead projects, help shape the team and strategy of the group, contribute significantly to prioritization of the team objectives and interact with and create and nurture the cross-functional relationships interacting with various therapeutic areas such diabetes and obesity, neuroscience, immunology and oncology. Responsibilities: Contribute to projects in oral macrocycles, chemical biology or peptide frameworks combining aspect of molecule design and conjugation at the interface of small molecules and peptides. Work on (both directionally and operationally) molecule engineering efforts from lead identification to lead optimization and contribute along the way to phase 1b and beyond. Lead display screening efforts from lead finding to lead optimization of oral macrocyclic peptide discovery projects Learn about and enhance the platform technology efforts at Protomer to accelerate the lead finding and optimization process. Work collaboratively in the group to achieve a common goal but also provide independent perspective and scientific rationale and contribute to strategy and execution. Take on dedicated molecular engineering efforts towards targets of high conviction and use speed and prioritization to advance synthetic efforts both at Protomer and wider Lilly groups and through collaboration with the rest of LRL. Inspire people to collaborate in inventing great medicines by removing barriers, committing to high quality scientific hypotheses, and accelerating where possible. Keep safety as a top priority at all times, striving toward a proactive safety culture. Be an advocate for diversity and inclusion in our recruiting, retaining and developing scientists, with a commitment to coaching and development of scientists. Be a good teammate and work effectively, responsibly and professionally with colleagues at Protomer and across Lilly. Qualifications: PhD or post-doctoral degree in chemistry, synthetic chemistry, chemical biology or related field with significant experience in these fields and a proven track record of research success. · Additional Skills Knowledge of some of the latest developments in developing oral macrocyclic peptides or library based selection approaches. Proven track record of library-base screening or lead optimization efforts using display technologies/OBOC libraries/DEL technologies, and ideally both in oral macrocycles or alternative experience working with peptides demonstrating an understanding of biophysical and biochemical properties that impact these types of molecules. Experience in bioinformatics, NGS analysis, peptide library designs. Deep knowledge and understanding of molecular biology techniques. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation. Knowledge of lab automation systems to streamline the experimental protocols and create workflows. Familiarity with innovative computational and structural efforts for hit identification and lead optimization in macrocyclic peptides. Basic understanding of computational and AI/machine learning techniques used for the development and engineering of oral macrocyclic peptide medicines. Understanding the whole drug discovery process including lead generation and lead optimization and will partner with cross functional groups including other areas within Medicine Innovation Hub, therapeutic areas, ADME, nonclinical safety assessment and PK/PD. Open, transparent and able to communicate equally well with employees, team members and cross-functional and/or senior leadership. Must be an excellent teammate, strong attention to detail, strong problem-solving skills, a high level of learning agility, with the ability to lead within a globally matrixed organization and across functions. Ability to think strategically, actively identifying gaps in competencies or capabilities within the organization and taking initiative to drive continuous improvement across Protomer. Additional Information: · Some domestic and international travel is anticipated and expected. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $133,500 - $217,800 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly

Posted 30+ days ago

Prime Medicine logo
Prime MedicineCambridge, MA
Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com . Co-op Assignment Overview Prime Medicine is seeking a co-op for the Spring 2026 semester with experience in cellular-based studies to join the Lung Biology team. The candidate will be involved in supporting critical efforts in developing prime editing therapies for Cystic Fibrosis patients. This role will focus on supporting preclinical and in vitro studies with an emphasis on flow cytometry, tissue processing, and advanced cell culture systems such as air–liquid interface (ALI) cultures. The successful candidate will thrive in a fast-paced research program and will enjoy working with colleagues within and across teams from multi-disciplinary backgrounds. Primary Responsibilities: Keen interest in learning and performing the downstream analysis of in vivo studies, including tissue sample preparation, in vitro assays (PCR and Next-gen sequencing) and data analysis Set up air–liquid cultures of human bronchial epithelial cells and maintain them throughout the experimental period Plan and execute in vitro assays to evaluate gene editing activity in relevant primary cell models Follow protocols, standard operating procedures, execute assigned tasks and maintain ELN. Share responsibility in lab reagent inventory and maintaining equipment. Work and collaborate cross-functionally with colleagues. Collect, analyze and present data in team meetings. Qualifications: Bachelors/Masters candidate in Biology-related major Direct experience performing routine wet lab procedures and experiments Hands on experience with sterile techniques and culturing of mammalian cell culture including primary cells Experience with tissue sample preparation and immunostaining assays (flow cytometry, FACS, ICC/IHC) is a plus Preferred Qualifications: Flow cytometry/FACS experience, including sample preparation and data analysis In vitro molecular assays such as PCR/RT-qPCR Gene editing technologies and viral and/or non-viral delivery What We Offer: A cutting-edge team open to mentorship and networking. Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc. Participation in regular seminars with industry experts. Full participation in employee activities including learning and development offerings, social activities, etc. NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Posted 1 week ago

Bristol Myers Squibb logo
Bristol Myers SquibbCambridge Crossing, MA
Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. Position Summary: Join our world-class ADC Discovery team and play a pivotal role in advancing next-generation oncology therapeutics. As a Senior Principal Scientist, you will lead innovative projects from concept to clinic, leveraging proprietary technologies and collaborating with top experts in the field. You'll have the autonomy to shape scientific strategy, mentor rising talent, and make a tangible impact on patient outcomes. Our team thrives on creativity, rigorous science, and a shared commitment to transforming cancer care. We are seeking a creative scientist leader with experience leading antibody-drug conjugate (ADC) drug discovery teams from target concept to IND filing. The successful candidate will contribute to the next wave of ADC innovation as a member of the Discovery Biology ADC Team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. Experience discovering novel linker-payloads beyond traditional cytotoxic linkers is preferred. The qualified candidate should be a collaborative, highly motivated, and creative scientist capable of working across highly matrixed teams to advance drug discovery programs. They will be dedicated to leading matrixed ADC discovery project teams from the early stages/target concept through to IND filing. This individual will work with leadership and across the company to fuel the next wave of ADC innovation. They will lead a team of scientists to deliver a wide range of biology studies to include supporting ADC candidate discovery and characterization as well as collaborating with bioinformaticians and translational research scientists to deliver patient stratification strategies. Experience with surface antigen target identification and validation and/or design of linker-payloads beyond traditional cytotoxic linkers is preferred. Position Responsibilities: In the role as a Senior Principal Scientist within the ADC Discovery Biology team, the ideal candidate will: Lead highly matrixed ADC discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation. Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates Leverage experience and insights to contribute to the next wave of ADC innovation, including beyond existing payload classes. Collaborate with functional area leads e.g. pharmacology, DMPK, bioinformatics to drive programs forward, including helping to define program priorities and risks. Apply extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships Present complex concepts to a range of audiences including governance and full team project meetings. Utilize excellent communication and interpersonal skills. Communicate via email, meetings, and reports. Experience = Basic Qualifications: Bachelor's Degree 10+ years of academic and / or industry experience Or Master's Degree 8+ years of academic and / or industry experience Or Ph.D. or equivalent advanced degree in the Life Sciences 6+ years of academic and / or industry experience 2+ years of leadership experience Preferred Qualifications: Ph.D. or equivalent advanced degree in the Life Sciences 6+ years of industry experience 2+ years of leadership experience Experience profiling and developing complex biologics (i.e. bispecifics, biparatopics, masked antibodies) Experience profiling and developing linker-payloads delivering both cytotoxic and targeted payload classes Experience contributing to an IND Experience leading and collaborating across matrixed ADC discovery programs from concept to IND Experienced in the design, development and optimization of high-throughput cell-based assays for antibody screening and ADC activity Strong leadership, interpersonal, and communication skills. Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work. Ability to summarize and interpret complex scientific data in a clear, concise, and accurate manner. Experience leading, coaching and mentoring a team of lab-based in vitro biologists Excellent oral and written communication skills. Ability to communicate well with peers, supervisors, and governance committees Strong problem-solving skills and understanding of complex scientific principles and demonstrated experience leveraging AI to refine strategic and tactical planning #LI-Onsite If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Cambridge Crossing: $181,930 - $220,451 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/ . Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Posted 2 weeks ago

Bristol Myers Squibb logo
Bristol Myers SquibbCambridge Crossing, MA
Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. Position Summary Discover Biotherapeutics (DBTx) & Leads Discovery & Optimization (LDO) is a dynamic, innovative organization that leverages state-of-the-art technologies and broad scientific expertise to evaluate therapeutic candidates and deliver comprehensive in vitro datasets across all stages of drug discovery at Bristol Myers Squibb. The Chemical Biology team in DBTx-LDO Cambridge is seeking a highly motivated undergraduate scientist for a 10-week internship in Summer 2026. The successful candidate will generate data to help the team drive innovation in several core areas, including new target identification, target engagement and mechanism deconvolution, and the evaluation and advancement of novel drug discovery modalities. Primary responsibilities will include the development, optimization, and execution of induced proximity assays, alongside molecular biology techniques such as cell line characterization and Western blotting. The full-time internship will take place June - August 2026. Key Responsibilities Perform cell-based studies using a variety of laboratory techniques, including mammalian cell culture, Western blotting, induced proximity assays, and genetic engineering (stable and transient transfections) Collaborate with a cross-functional team of chemical biologists, chemists, biochemists, and proteomics experts to develop new technologies and discover new targets Maintain thorough scientific records and present at group meetings Qualifications & Experience Two years of cell biology and/or molecular biology course work at the college level, a strong academic record (≥ 3.0 GPA), and at least three semesters of laboratory course work and/or research Trained in molecular and cell biology Experience independently generating reliable data and performing data analysis Hands-on experience in cell culture and characterization of cells from human and animal tissues is desired Self-motivated to learn and contribute, demonstrated examples of independent productivity and team-based interpersonal skills Excellent communication, record keeping, presentation, collaboration and organizational skills Enthusiasm for science, laboratory work, and drug discovery Prior laboratory experience in an academic setting and/or biotechnology/pharmaceutical industry All candidates must be authorized to work in the US both at the time of hire and for the duration of their employment. Please note that immigration or visa sponsorship is not available for this position. This is a temporary, time-bound position intended for the duration of the internship or co-op program. Employment in this role does not imply or guarantee ongoing or permanent employment with BMS. The starting hourly compensation for this assignment is within the range of $27.00 to $29.00/hr. Please note that the final individual compensation and any applicable benefits will be determined by your employer of record (and not BMS). Factors influencing this decision may include the characteristics of the assignment, such as demonstrated experience, required skill, and the geographic location of the job. Compensation details are subject to change. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/ . Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Posted 2 weeks ago

Blueprint Medicines Corporation logo
Blueprint Medicines CorporationCambridge, MA
Co-op, Biology Drug Discovery Address: 45 Sidney Street Cambridge, MA, 02139 Blueprint Medicines, a Sanofi company, is a global biopharmaceutical company that invents life-changing medicines. We seek to improve and extend patients' lives by solving important medical problems, with a focus on allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a track record of success with two approved medicines, including AYVAKIT/AYVAKYT (avapritinib) which we are bringing to patients with SM in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases and solid tumors. Responsibilities: We are seeking a motivated graduate-level co-op student interested in contributing to our drug discovery programs, with a focus target validation and assay development for testing candidate drug compounds. This student will apply advanced molecular biology techniques to evaluate candidate compounds and contribute to the scientific direction of our programs. Projects will be crafted along one or multiple of the following key areas based on interest and business needs: Lab Work: Design, execute, and analyze in vitro cellular assays across a variety of cell lines to assess drug efficacy and biological impact Perform mechanism of action studies on human and engineered cell lines, including proliferation assays, signaling assays, protein-protein interactions, and high content imaging assays Maintain cell cultures, generate stable cell lines using RNA interference (RNAi) or gene editing techniques (CRISPR/Cas-9) Execute drug combination studies on cell lines of interest to evaluate synergistic or antagonistic effects. Data Analysis and Documentation: Analyze experimental data using GraphPad Prism, Excel, and other relevant tools Maintain accurate and detailed electronic laboratory notebooks in compliance with Blueprint Medicines' standards Collaboration and Communication: Participate in regular team meetings, present findings, and contribute to scientific discussions Collaborate with cross-functional teams, seek feedback, and actively contribute to a culture of innovation Perform other duties as assigned. ONSITE EXPECTATIONS: This is a lab-based position, and the Co-op is expected to work onsite 5 days/week. Qualifications: Currently enrolled student pursuing a PhD or master's program in biomedical sciences, molecular biology, or related field 1-2 years of independent laboratory research Strong foundation in cellular and molecular biology Proficiency in core lab techniques (e.g., tissue culture, Western blotting, DNA/RNA extraction, immunofluorescence, cell proliferation and viability assays, experience generating cell lines a plus) What additional qualifications will make you a stronger candidate? Strong commitment to pursuing a career in research Excellent communication, organizational, and analytical skills Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism Our Co-op Program: Blueprint's Co-op program is ~6 months long. The program is designed to provide students with deep functional expertise within their department and a broad understanding of the life sciences industry. Co-ops are paired with dedicated mentors for personalized learning and career development guidance. The program includes lunch and learn sessions, networking events, a student volunteer day, and other networking opportunities. It culminates in a final poster presentation where interns showcase their work. Dress Code: Blueprint's offices are a business casual environment. Business casual means attire that is professional but also relaxed, such as slacks or business dress pants, skirts/dresses, khakis, chinos, or dark jeans without holes paired with button-down shirts, sweaters, blouses, or polo shirts and closed-toed shoes. It typically excludes formal suits or very casual clothing such as athletic wear or flip flops. Spring 2026 Co-op Program Dates: Monday, January 5th - Friday, June 26th Pay Range: Our Co-ops are paid hourly based on previous Co-op experience. The expected pay range for this role is $32.00 - $35.00per hour. Who will my employer be? You will be employed by Magnit, LLC for all purposes and not Blueprint Medicines, a Sanofi Company. As your employer, Magnit will assign you to provide services to Blueprint as a co-op or intern. Under this arrangement, co-ops and interns will have the opportunity to learn about Blueprint Medicines, a Sanofi Company and gain meaningful hands-on experience. Please note: Co-op and interns are not employees of Blueprint in any way, and do not qualify for participation in Blueprint's benefit plans. Equity, Diversity, Inclusion and Affirmative Action "To do our best work we need different viewpoints. Therefore, we celebrate diversity and embrace inclusion. As an equal opportunity employer, we are dedicated to building a team that represents a variety of backgrounds, perspectives, and skills. We strive to ensure that we maintain a positive and enriching work environment for all." For more information on Magnit's privacy notice, click on privacy notice. Magnit, LLC recognizes the importance of individually held beliefs re: appropriate dress/attire and will reasonably accommodate an employee's religious beliefs unless the accommodation creates an undue hardship. Those requesting attire accommodation based on religious beliefs should reach out to their Magnit representative. Magnit is a Global industry leader with one simple goal of shaping and delivering the next chapter in workforce management for our employees, clients, suppliers, and partners around the world. Why Blueprint? At Blueprint Medicines, a Sanofi Company, we achieve impactful results because of our global crew of compassionate innovators - the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

Posted 5 days ago

L logo
Legend Biotech CorpPhiladelphia, PA
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide. Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking Director, Vector Biology as part of the Exploratory Technology team based in Philadelphia, PA. Role Overview We are seeking a highly experienced and strategic leader to join our Vector Biology team as Director. This role will oversee lentiviral vector (LVV) production and early process development, while managing a team of 10+ scientists and collaborating cross-functionally with internal and external stakeholders. Key Responsibilities Lead and manage a team of 10+ direct reports within the Vector Biology group. Oversee lentiviral vector (LVV) production to support internal research initiatives. Provide conventional vector core services to internal stakeholders. Drive early-stage process development for LVV manufacturing, including upstream, downstream, and analytical workflows. Set strategic direction for LVV Chemistry, Manufacturing, and Controls (CMC). Represent the Vector Biology team in cross-functional collaborations with Discovery Research, Early Drug Development (EDD), and Technical Development teams. Lead internal and external technology transfers for LVV manufacturing. Requirements Ph.D. in Chemical Engineering, Virology, Molecular Biology, or a related field. Minimum of 5 years of industry experience in cell and gene therapy, with a focus on viral vector production. Proven leadership experience managing teams of 5 or more direct reports. Hands-on experience with LVV manufacturing using bioreactors and industrial-scale downstream processes. Strong understanding of CMC requirements for viral vectors. Deep knowledge and hands-on experience in viral vector technologies. Experience working with Contract Development and Manufacturing Organizations (CDMOs). Experience providing vector core services is a plus. #Li-JK1 #Li-Hybrid The anticipated base pay range for this is: $187,989 - $246,735 USD. The anticipated base pay range is: $187,989-$246,735 USD Benefits: We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work. EEO Statement Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law. Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions. Legend Biotech maintains a drug-free workplace.

Posted 30+ days ago

M logo
Minnesota StateSaint Cloud, MN
All Job Postings will close at 12:01 a.m. CT on the specified Closing Date (if designated). Working Title: Adjunct Instructors- Biology Special Topics Institution: St. Cloud State University Classification Title: State Univ Adjunct Unit Bargaining Unit / Union: 209: Inter Faculty Organization City: St. Cloud FLSA: Job Exempt Full Time / Part Time: Employment Condition: Unclassified- Limited Academic (Fixed Term) Salary Range: $38,586.00 - $200,000.00 Job Description St. Cloud State University is seeking applications for potential part-time Adjunct Instructors who qualify to teach in the College of Science and Engineering Department of Biology in specialty courses. Individuals interested in being considered for part-time, Adjunct teaching positions in the Biology Department should have the qualifications outlined in the Required Qualifications section. Compensation is per credit, the current credit rate is a minimum of $1819 per credit. This adjunct position will remain open for 1 year to allow departments' access to candidate pools when there is a need to hire an adjunct to teach a course(s) during defined academic semester(s). Minimum Qualifications Bachelor's degree Minimum of five years of work experience or an advanced degree in a field related to the specialty course Certifications relevant to the specialty course; Please contact the Biology Department for more information biology@stcloudstate.edu Evidence of demonstrated ability to teach and work with persons from culturally diverse backgrounds Preferred Qualification Advanced Degree in a field related to the specialty course. Please contact the Biology Department for more information biology@stcloudstate.edu Teaching experience Required Documents (Uploaded at Time of Application) Resume/CV Cover Letter Three (3) professional references Unofficial transcipts Work Shift (Hours / Days of work) Varies About The successful candidate will share St. Cloud State's commitment to our mission, and in particular, the value we place in diversity, equity, and inclusion (DEI) as outlined in SCSU's It's Time strategic framework. Notably, we uphold the advancement of diversity, equity, and inclusion and engage in intentional actions to address systemic inequities throughout the university and surrounding environment. DEI values, practices, and strategies are embedded into the fabric of our institution and campus community, and they align with the priorities expressed in the Minnesota State system's Equity 2030 initiative. SCSU expects all of its employees to help advance these practices and to contribute to the development of an anti-racist, inclusive community. Employment for this position is covered by the collective bargaining agreement for the Inter Faculty Organization (IFO) which can be found https://www.ifo.org/ St. Cloud State University is committed to excellence and actively supports cultural diversity. To promote this endeavor, we invite individuals who contribute to such diversity to apply, including minorities, women, LGBTQIA+, persons with disabilities and veterans. St. Cloud State University does not discriminate on the basis of race, sex, color, creed, religion, age, national origin, disability, marital status, status with regards to public assistance, sexual orientation, gender identity, gender expression, or status as a U.S. veteran. The Title IX coordinator at St. Cloud State University is Chocoletta Simpson. For additional information, contact the Office of Institutional Equity & Access, (320) 308-5123, Admin. Services Bldg. Rm 121 Benefits Information: At Minnesota State, we have a GREAT BENEFITS PACKAGE! Our generous benefits include 11 paid Holidays, Vacation Time, Sick Time, six weeks of Paid Parental Leave, low cost medical and dental insurance with low deductibles ($250 - $1500), a Pension Plan, 457(b) and 403(b) retirement plans and other retirement investment options, pre-tax medical and dental expense (with roll-over option) and dependent care accounts, employer paid life insurance, short and long term disability, as well as professional development and a tuition waiver program for employees and their dependents, etc. We promote the health and well-being of our employees and take work/life balance seriously. Desired Start Date: Position End Date: Open Date: 03-03-2025 Close Date: 03-03-2026 Posting Contact Name: Renee Denise Bertram Posting Contact Email: ac1159yu@minnstate.edu

Posted 30+ days ago

Montgomery College logo
Montgomery CollegeMaryland, LA
Job Description Montgomery College, Rockville campus, is seeking a full-time Biology faculty member to fill a position starting January 2026. We are looking for an enthusiastic and dedicated educator who exhibits a high degree of professionalism, a strong commitment to our students, and the ability to motivate and educate in an engaging manner. Important qualities expected in the candidate include strong verbal and written communication skills, experience working with students of different backgrounds, and commitment to the community college mission. This position is part of a collective bargaining unit. Montgomery College has a long history of successfully preparing students for transfer to four-year institutions like the University of Maryland, Georgetown University, George Washington University, the University of Maryland, Baltimore County and the Universities at Shady Grove. Montgomery College has state-of-the art science facilities and equipment. MC's science buildings are less than 15 years old. The successful candidate will appreciate teaching in a multi-cultural environment and will welcome the opportunity to work with students with diverse learning abilities. The faculty member will primarily teach our Principles of Biology I, Principles of Genetics, and/or other courses as needed. Faculty duties include classroom instruction, assessment, curriculum development, advising, professional inquiry, committee work and utilizing instructional technology. The opportunity to teach honors students or engaging students in research is also supported and encouraged. Teaching assignments may include various delivery modes, such as face-to-face, online, remote, hybrid and/or blended formats during days, evenings and weekends. Montgomery College has four campuses and instructs courses at area high schools, as part of the growing dual enrollment program. Faculty may be assigned to any of these campuses and/or teaching different modalities. Montgomery College is a strong advocate of professional development and invests in its faculty. Duties include but are not limited to: Teaches non-major and major-level courses; teaching assignment expected to include Principles of Biology I (BIOL 150) and Principles of Genetics (BIOL 222). Opportunity may be available to teach other courses like microbiology (BIOL 210). Teaches 30 semester hours per academic year. Prepares course materials such as syllabi, homework assignments and handouts; evaluates and grades students' exams, assignments, and papers. Holds office hours for student help. Teaches a varied schedule of courses that may include day, night, early morning, weekend and/or accelerated sections, compressed and online. Opportunities may exist for teaching summer classes. Engages students in their learning through active, collaborative learning approaches. Incorporates the use of a learning management system (Blackboard) and other relevant technology into instruction. Mentors students outside of class to assist them with being successful college students. Advises students about program curriculum, transfer options to four-year institutions, and professional/career opportunities. Serves on, or leads, department, discipline, campus and college committees. Maintains an active program of professional development and participates in professional organizations and activities. Engages in the expansion and implementation of assessments for courses, programs and learning outcomes with the goal of increasing student success. Required Qualifications: Master's degree in Biological Science, Genetics, Cell Biology, Biochemistry, or other closely related field. Minimum of two (2) years of teaching experience in two-year and/or four-year institutions. Understanding of and commitment to student success including increasing retention, transfer and graduation. Eligible applicants must currently be authorized to work in the United States and not require employer visa sponsorship., Preferred Qualifications: Ph.D. in Biological Science, Genetics, Cell Biology, Biochemistry, or other closely related field. Three (3) years of teaching experience at college level. Demonstrated experience in implementing or developing undergraduate research opportunities. Demonstrated experience using various teaching modalities (face-to-face, remote, blended/hybrid, and online). Ability to effectively engage with and facilitate learning for students of diverse backgrounds, cultures, and experiences. Familiarity with learning management systems (e.g. Blackboard, Canvas). Demonstrated experience teaching major-level courses such as general biology, genetics, microbiology, and cell biology. Demonstrated experience using techniques to engage students in the classroom. Hiring Range: $63,254 to $96,299 annually. Application Process: Click Here to apply. Online applications must be received by October 5, 2025. A cover letter is required. A statement of teaching philosophy is required. Unofficial transcripts are required. All documents should be submitted in a single pdf file. For degrees earned outside of the U.S., a copy of your education equivalency, conducted by a nationally recognized evaluation service, must be included in your application. As a condition of employment, the following are required at the time of hire: Successful completion of a background check and degree verification (if applicable). Participation in a retirement plan (Pension or Optional Retirement Plan, depending on the position). If you are already retired from the Maryland State Retirement System, you may not enroll in a Maryland State Retirement System plan at Montgomery College and may have earnings restrictions, per state law. Our benefits package includes: sick leave, paid holidays, medical, dental, vision, group legal benefits, professional development, retirement plan, educational assistance, tuition waiver for employee and dependents, wellness programming including onsite gyms, pools and classes. If a reasonable accommodation is needed to participate in the job application or interview process, please contact Human Resources and Strategic Talent Management at 240-567-5353 or HRSTM@montgomerycollege.edu. We require at least two weeks advance notice to enable us to provide the requested accommodation. Montgomery College is an equal opportunity employer committed to promoting and fostering diversity among its student body, faculty, and staff. Montgomery College is a tobacco-free and smoke-free workplace. Closing Date Sunday, October 5, 2025

Posted 1 week ago

Altos Labs logo
Altos LabsSan Francisco, CA
Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. For more information, see our website at altoslabs.com. Our Value Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission. Diversity at Altos We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos As an individual contributor and Scientist at the Bay Area Institute of Science, you will play a key role in advancing Altos' scientific programs about brain aging and neurodegeneration. Working closely with the Frost lab, you will be responsible for designing and implementing innovative experimental approaches using metabolic and light microscopy techniques. This includes developing and utilizing cell types derived from the central nervous system (CNS), applying genetic perturbations to these cells, and employing experimental approaches that include light microscopy and metabolic profiling. The ideal candidate will possess a robust understanding of CNS cell biology, the metabolic shifts characteristic of aging and neurodegenerative diseases, and proficiency in advanced microscopy, image analysis and metabolism techniques. This role reports to Principal Investigator Adam Frost. Responsibilities Provide advanced cell culture, metabolic, and genetic manipulation of iPSC-derived CNS cell types and primary CNS cells. Provide independent design and implementation of all phases of light microscopy experimentation, including experimental design, microscope operation, image capture, and quantitative image analysis. Engage with cross-Altos research labs to bridge in vitro with in vivo models and to suggest complementary genetic and morphological profiling approaches. Stay abreast of advances in light microscopy methods and technologies so that these can be brought to Altos as needed. Assist other scientists in the Frost group and beyond in quantitative analysis of microscope images using tools such as Zen, Elements, Arivis, Napari, Fiji, and other software. When appropriate, manage image analysis collaborations with the Computer Vision team. Who You Are Minimum qualifications PhD in a related field, such as Cell Biology, Neuroscience, Genetics Thorough understanding of the principles of light microscopy image visualization, analysis, and processing. Demonstrable understanding of cell metabolism, including the impact of metabolism on chromatin and cell fate. Excellent communication skills and proven ability to collaborate within a dynamic team. Preferred qualifications Primary CNS cell isolation and culture CRISPR-based genetic manipulation of mammalian cells Practical experience with the management of terabyte-size microscopy datasets Literacy in MATLAB, R, or Python Practical experience with cellular image segmentation tools #LI-NN1 The salary range for Redwood City, CA Scientist I, Imaging Technologies: $127,500 - $172,500 Scientist I, Imaging Technologies: $150,000 - $205,200 Senior Scientist I, Imaging Technologies: $171,000 - $240,000 Senior Scientist II, Imaging Technologies: $200,000 - $282,000 Exact compensation may vary based on skills, experience, and location. For UK applicants, before submitting your application: Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice) This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. Equal Opportunity Employment We value collaboration and scientific excellence. We believe that diverse perspectives and a culture of belonging are foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment. Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging. Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at https://www.linkedin.com/pulse/how-spot-avoid-online-job-scams-biron-clark/

Posted 30+ days ago

Bryant & Stratton College logo
Bryant & Stratton CollegeRichmond, VA
Unlock your full potential in the innovative and inclusive environment at Bryant & Stratton College. We are a career-focused, private, nonprofit college built differently to serve the needs of students, alumni, associates, employers, and the community. Founded in 1854, Bryant & Stratton College offers real-world education leading to bachelor's, associate's, and professional certificates after completion in the fields of healthcare, technology, legal, business, graphic design, and more. We offer a comprehensive benefits package that includes competitive salaries, medical/dental/vision insurance, generous paid time off, 401K, and company-paid college tuition for associates and their families. Bryant & Stratton College is a Public Service Loan Forgiveness certified employer. Apply today! The Richmond Campus of Bryant & Stratton College is accepting applications for a full-time Associate Professor: Biology. Responsibilities: Teach Anatomy & Physiology I & II, Microbiology and/or Pathophysiology (both lecture and lab portions) for day, evening and weekend classes as scheduled. Utilize active learning (facilitation), authentic assessment, and portfolio assignments to support the teaching and learning outcomes of Bryant & Stratton College. Maintain a current knowledge of teaching discipline/field of study evidenced in Teaching Portfolio. Adhere to and uphold all established Bryant & Stratton College operational policies and procedures as described in operation documentation (official catalog, Faculty Guide). Maintain effective communication with students and colleagues. Maintain proficiency with technology, including Microsoft Office 365 products and Learning Management Systems. Provide instruction in face to face and virtual (via Teams) modalities. Adhere to all required Bryant & Stratton College administrative and classroom delivery duties and requirements as outlined in the job description for full-time instructional associates. Serve as a Bryant & Stratton College campus leader by attending and participating in campus-wide initiatives and functions, including, but not limited to staff meetings, in-services, workshops and graduation. Qualifications: Master's Degree or higher in relevant Biology, Zoology, or Doctorate in Medicine. Effective in directing and evaluating student learning and laboratory performance. Demonstrated teaching experience or aptitude. Strong commitment to professional development, application of best practices and student success. Strong team player. Ability to make meaningful and positive connections with a diverse student body in a career college environment. Bryant & Stratton College is an Equal Opportunity Employer.

Posted 30+ days ago

Lipscomb University logo
Lipscomb UniversityNashville, TN
The Biology department is looking for qualified and experienced tutors to provide in-person tutoring to students. Tutors must have outstanding grades in their Freshman and Sophomore years. Must be a current Lipscomb University student. This position may be federal work study eligible.

Posted 30+ days ago

Generate Biomedicines logo
Generate BiomedicinesSomerville, MA
About Generate:Biomedicines Generate:Biomedicines is a new kind of therapeutics company - existing at the intersection of machine learning, biological engineering, and medicine - pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees. The Role: The Protein Engineering team is seeking a highly innovative and collaborative Senior Scientist I to drive the development and implementation of large-scale, NGS-based functional assays. In this role, you will lead the translation of Generate's cutting-edge technologies into high-impact therapeutic applications that harness the full power of our computational and experimental platforms. This role will collaborate closely with teams across DNA Read/Write, Prototyping Lab, Machine Learning, and Early-Stage Biology to pioneer novel workflows for scalable functional screening. This is an ideal opportunity for a scientist who thrives at the interface of technology development and translational potential - someone who enjoys building new tools and using them to ask meaningful biological questions. Here's how you will contribute: Design and implement state-of-the art large-scale quantitative assays to evaluate the biological function of protein designs Collaborate with computational teams to guide experimental design and data analysis Translate emerging technologies from Prototyping Lab into scalable, validated platforms for therapeutic exploration Communicate experimental strategies, results, and insights clearly and effectively across multidisciplinary teams Support platform innovation with theoretical analysis, modeling, and literature review Generate novel intellectual property and contribute to patent filings The Ideal Candidate will have: PhD in biomedical engineering, synthetic or systems biology, biophysics, or related discipline with 4+ years of relevant experience or BS/MS with 10+ years of relevant experience. Exceptional candidates with fewer years of experience may also be considered Expertise in synthetic biology or protein engineering, with particular emphasis on DNA library construction, protein library screening, and NGS assay development Proficiency in computational analysis using Python, MATLAB, or related tools, particularly for NGS and high-throughput datasets Experience with gene editing technologies for developing engineered cell lines Strong quantitative mindset and scientific intuition Demonstrated ability to translate experimental tools into biologically meaningful applications Highly collaborative, intellectually curious, and motivated to work across disciplines Experience with computational modeling and/or laboratory automation is a plus #LI-AE1 Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto. Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Per Year Salary Range $124,000-$174,000 USD

Posted 30+ days ago

The Scripps Research Institute logo
The Scripps Research InstituteSan Diego, CA
ABOUT US: Scripps Research is a nonprofit biomedical institute ranked as one of the most influential in the world for its impact on innovation. In 2024, we celebrated our 100-year legacy. This significant milestone has marked a century of seminal discoveries in immunology, infectious diseases (such as COVID-19, flu, HIV), neuroscience, heart disease, cancer, and more. Located in La Jolla, California, the institute houses six research departments, multiple Nobel laureates, a top-ranked graduate school and a leading postdoctoral training program. We work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and advances in digital and precision medicine. Together, we cultivate new scientific leaders and expand the frontiers of knowledge to deliver medical breakthroughs impacting human health around the globe. If you have a passion for making a difference, this could be your opportunity to join our transformative team. Celebrating a Century: https://100.scripps.edu/ POSITION TITLE: Postdoctoral Associate - Aging: Lacrimal Gland Biology POSITION SUMMARY: The Makarenkova Lab at Scripps Research is seeking a highly motivated Postdoctoral Associate to join our team and contribute to cutting-edge research on age-related diseases of the eye. With increased life expectancy, the prevalence of age-related diseases is expected to rise, including dry eye disease, a condition affecting millions of older adults worldwide. Tear dysfunction can lead to irritation, pain, and blurred vision, significantly impacting quality of life. The lacrimal gland (LG), an exocrine tubuloacinar gland, is responsible for secreting the aqueous layer of the tear film. Over a lifetime, the corneal surface and LG are exposed to bacterial and viral infections that can disrupt epithelial cell homeostasis and trigger chronic inflammation. Yet, the precise mechanisms underlying LG aging, and the specific cell populations involved, remain largely unknown. To address this gap, our lab has performed high-throughput single-cell RNA sequencing (scRNAseq) to generate the first comprehensive single-cell atlases of young adult and aged LGs. Using Fluorescence Activated Cell Sorting (FACS), we have also isolated and sequenced specific LG epithelial cell populations from young and aged mice, revealing novel cell markers and previously undescribed cell populations. The successful candidate will: Analyze scRNAseq datasets and integrate findings with spatial transcriptomics and bulk RNAseq Validate novel markers and cell populations using immunohistochemistry, Western blotting, qRT-PCR, and LG functional assays (secretion, proliferation, inflammatory readouts). Design and execute independent subprojects based on experience and interests. Present findings at lab meetings, journal clubs, and internal/external conferences Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges. Make Scripps Research your next step to advance and develop your career. Click here to learn more about our Postdoctoral Program and Services: https://education.scripps.edu/postdoctoral/ REQUIREMENTS: Ph.D. in molecular biology, cell biology, immunology, bioinformatics, or a related field. Some experience with RStudio and Seurat for single-cell data analysis. Some experience with cell dissociation protocols and handling primary tissues. Willingness to work with mouse colonies, including mouse genotyping. COMPENSATION: Postdoctoral Associates will be hired following the National Institute of Health and California's exempt salary guidelines, which provide for a starting range of $68,640- $73,230. Consideration will be given to experience that exceeds the listed requirements. COMPREHENSIVE BENEFITS INCLUDE: Eligibility for retirement plans with employer contribution. Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more. Access to Flexible Spending Accounts (Medical/Dependent Care). Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members. Free, on-site parking. Pet Insurance The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff. EEO Statement:The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Posted 30+ days ago

California Life Company logo
California Life CompanySouth San Francisco, CA
Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: We are seeking a Head of Human Biology to lead Calico's efforts to use large scale human cohorts to systematically understand the biology of aging and disease pathogenesis, in order to discover and validate novel therapeutic targets. The Head of Human Biology will be a key member of Calico's Research leadership team. Candidates will have demonstrated interest in exploring genetic data in large human cohorts, with a strong record of scientific achievement. This person will be expected to have broad impact across the organization, leading both scientifically and strategically and playing a key role in the use of human data to advance Calico's long term research goals. This individual will possess strong leadership skills and a track record of successful discovery research and interest in translating discoveries into novel interventions in age-related diseases. The successful candidate will join an ecosystem of collaborative, enthusiastic, rigorous, interdisciplinary scientists who are employing state-of-the-art technologies and computational approaches to elucidate the fundamental mechanisms of aging and their impact on age-related diseases. Key Responsibilities: Direct a group of Principal Investigators and oversee their research programs Direct an independent research effort aimed at gaining valuable insights from human data Provide scientific direction, including clinical insights, for a broad range of translational projects Recruit top talent with human data as a key focus Join Calico's Scientific Review Committee Contribute overall to Calico's ambitious research efforts to understand the fundamental biology of human aging and discover mechanisms that contribute to human longevity Position Requirements: MD/PhD preferred, with PhD in computational biology, genetics, epidemiology, physiology, molecular/cellular biology, systems biology; relevant practical experience Rising/proven leader in academia or industry with 10+ years of professional experience Strong record of creative scientific achievement with a track record of impactful publications exploring human cohort data Recognized for novel mechanistic insights and important discoveries Experience managing other scientists Ability to integrate across many areas of biology with ease Excellent communication skills A passion to translate cutting-edge science into therapeutic opportunities Must be willing to work onsite 5 days per week Nice to Have: Experience with post-GWAS methods such as Mendelian randomization and variant interpretation Experience with association studies using high content phenotypes such as medical images Experience with experimental medicine or clinical drug development Familiarly with basic machine learning concepts 'Wet lab' experience Well-developed relationships with the academic scientific community The estimated base salary range for this role is $314,000 - $374,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Posted 2 days ago

Blueprint Medicines Corporation logo

Associate Scientist Biology

Blueprint Medicines CorporationCambridge, MA

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Job Description

How will your role help us transform hope into reality?

Research, identify, and validate novel oncology targets and small molecule drug discovery, utilizing knowledge of bioengineering to develop and conduct cellular assays to support Blueprint Medicine's novel drug discovery efforts.

What will you do?

  • Manages and QC routines assays performed at CRO and upload data to our server. (15%)
  • Optimize and employ cellular and molecular assays such as Western blotting, Elisa and immunofluorescence-based assays to elucidate mechanistic biology of potential drug targets and mechanism of action of small molecules. (20%)
  • Present research findings at team meetings. (5%)
  • Maintain our automation platform and is the point of contact with the vendor when needed (such as major issues to be fixed or implementation of new updates). (15%)
  • Design and development of automation methods for biological assays for several projects. Teach colleagues how to use those methods and troubleshoot when necessary. (15%)
  • Cell culture Maintenance. (10%)
  • Run routine assays when needed. (10%)
  • Maintain detailed and critical experimental data records that are published in ELN according to industry compliance. (10%)

What minimum qualifications do we require?

Master's degree in Bioengineering, Biomedical Engineering, or a closely related biological or life sciences field (or foreign equivalent degree), plus 1 year of experience in biological research for oncology drug development.

Experience, which may be gained concurrently, must include:

  • 1 year of experience in maintaining, expanding, and freezing cell lines.
  • 1 year of experience with running routine assays such as Alphalisa pERK and proliferation assays.
  • 1 year of experience in using and programming liquid handlers such as Bravo, Biomek, Integra Assist Plus and D300.
  • 1 year of experience in analyzing cell research data and presenting it to the team.
  • 1 year of experience in analyzing and presenting scientific research papers.
  • 1 year of experience in maintaining detailed ELN to ensure data reproducibility.
  • This position is part of Blueprint Medicines' employee referral program and is eligible for an employee referral incentive bonus.

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators - the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equal Employment Opportunity

At Blueprint Medicines, we foster an environment of fair treatment and full participation for all of our employees as we navigate complex challenges in pursuing our mission to improve the lives of patients. We celebrate our unique differences and varied career and life experiences so that we can sustain our diverse culture and ensure everyone feels accepted. We are committed to non-discrimination, equal employment opportunity, as well as an inclusive recruitment process. We consider all qualified applicants based on merit and without regard to race, color, sex, gender identity, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable federal or state law.

We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com. We are also an E-Verify Employer. For more information, please see our EEO Policy Statement, the E-Verify Participation Poster, the Right to Work Poster, and the EEO Know Your Rights Poster.

Blueprint Medicines, a Sanofi company, is a global biopharmaceutical company that invents life-changing medicines. We seek to improve and extend patients' lives by solving important medical problems, with a focus on allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a track record of success with two approved medicines, including AYVAKIT/AYVAKYT (avapritinib) which we are bringing to patients with SM in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases and solid tumors. For more information, visit www.BlueprintMedicines.com and follow us on X (formerly Twitter; @BlueprintMeds) and LinkedIn.

Requisition #: 25-604

#LI-DNI

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