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Senior Scientist, Biology-logo
Senior Scientist, Biology
Mariana OncologyWatertown, MA
Description: We are seeking a Senior Scientist, Biology to support the discovery of peptide ligands to specific cancer drug targets using mRNA display platform. Illustrative Breadth of Responsibilities: Design and execute biochemical and cellular experiments to characterize binding activities of radio-peptide ligands to cancer targets. High comfort level working with different kinds of radioemitters is a must. Support hit-lead optimization efforts by screening compounds in a radiolabeled binding assay using cancer cell lines, as well as intellectually contribute towards the screening cascade strategy design. Support internal and external mechanistic biology efforts to understand cell signaling impact of targeting specific cell surface proteins in cancer cell lines. Interpret and analyze data, prepare, and review IND-enabling study reports, communicate findings to project teams, stakeholders, and external collaborators. Requirements/Skills: Master's degree in Biology, Cell or Molecular Biology, Biotechnology, or a closely related scientific field. 5 years of drug discovery research experience within the biotech or pharmaceutical industries, including: o 2 years of experience with mRNA display and in vitro translation of unnatural amino acids; o 5 years of cell-based assay development using techniques including Flow cytometry (MACSQuant platform), live-cell imaging using Incuctye platform, protein quantification/characterization by western blot and ELISA; o 2 years of experience handling multiple types of radioisotopes to support in vitro assay development; and o 3 years of IND enabling/post-IND experience.

Posted 1 week ago

Adjunct Instructors - Biology Special Topics-logo
Adjunct Instructors - Biology Special Topics
Minnesota StateSaint Cloud, MN
All Job Postings will close at 12:01 a.m. CT on the specified Closing Date (if designated). Working Title: Adjunct Instructors- Biology Special Topics Institution: St. Cloud State University Classification Title: State Univ Adjunct Unit Bargaining Unit / Union: 209: Inter Faculty Organization City: St. Cloud FLSA: Job Exempt Full Time / Part Time: Employment Condition: Unclassified- Limited Academic (Fixed Term) Salary Range: $38,586.00 - $200,000.00 Job Description St. Cloud State University is seeking applications for potential part-time Adjunct Instructors who qualify to teach in the College of Science and Engineering Department of Biology in specialty courses. Individuals interested in being considered for part-time, Adjunct teaching positions in the Biology Department should have the qualifications outlined in the Required Qualifications section. Compensation is per credit, the current credit rate is a minimum of $1819 per credit. This adjunct position will remain open for 1 year to allow departments' access to candidate pools when there is a need to hire an adjunct to teach a course(s) during defined academic semester(s). Minimum Qualifications Bachelor's degree Minimum of five years of work experience or an advanced degree in a field related to the specialty course Certifications relevant to the specialty course; Please contact the Biology Department for more information biology@stcloudstate.edu Evidence of demonstrated ability to teach and work with persons from culturally diverse backgrounds Preferred Qualification Advanced Degree in a field related to the specialty course. Please contact the Biology Department for more information biology@stcloudstate.edu Teaching experience Required Documents (Uploaded at Time of Application) Resume/CV Cover Letter Three (3) professional references Unofficial transcipts Work Shift (Hours / Days of work) Varies About The successful candidate will share St. Cloud State's commitment to our mission, and in particular, the value we place in diversity, equity, and inclusion (DEI) as outlined in SCSU's It's Time strategic framework. Notably, we uphold the advancement of diversity, equity, and inclusion and engage in intentional actions to address systemic inequities throughout the university and surrounding environment. DEI values, practices, and strategies are embedded into the fabric of our institution and campus community, and they align with the priorities expressed in the Minnesota State system's Equity 2030 initiative. SCSU expects all of its employees to help advance these practices and to contribute to the development of an anti-racist, inclusive community. Employment for this position is covered by the collective bargaining agreement for the Inter Faculty Organization (IFO) which can be found https://www.ifo.org/ St. Cloud State University is committed to excellence and actively supports cultural diversity. To promote this endeavor, we invite individuals who contribute to such diversity to apply, including minorities, women, LGBTQIA+, persons with disabilities and veterans. St. Cloud State University does not discriminate on the basis of race, sex, color, creed, religion, age, national origin, disability, marital status, status with regards to public assistance, sexual orientation, gender identity, gender expression, or status as a U.S. veteran. The Title IX coordinator at St. Cloud State University is Chocoletta Simpson. For additional information, contact the Office of Institutional Equity & Access, (320) 308-5123, Admin. Services Bldg. Rm 121 Benefits Information: At Minnesota State, we have a GREAT BENEFITS PACKAGE! Our generous benefits include 11 paid Holidays, Vacation Time, Sick Time, six weeks of Paid Parental Leave, low cost medical and dental insurance with low deductibles ($250 - $1500), a Pension Plan, 457(b) and 403(b) retirement plans and other retirement investment options, pre-tax medical and dental expense (with roll-over option) and dependent care accounts, employer paid life insurance, short and long term disability, as well as professional development and a tuition waiver program for employees and their dependents, etc. We promote the health and well-being of our employees and take work/life balance seriously. Desired Start Date: Position End Date: Open Date: 03-03-2025 Close Date: 03-03-2026 Posting Contact Name: Renee Denise Bertram Posting Contact Email: ac1159yu@minnstate.edu

Posted 30+ days ago

Systems Biology Laboratory Support-logo
Systems Biology Laboratory Support
Parsons Commercial Technology Group Inc.Frederick, MD
In a world of possibilities, pursue one with endless opportunities. Imagine Next! When it comes to what you want in your career, if you can imagine it, you can do it at Parsons. Imagine a career working with exceptional people sharing a common quest. Imagine a workplace where you can be yourself. Where you can thrive. Where you can find your next, right now. We've got what you're looking for. Job Description: Parsons is looking for an amazingly talented Systems Biology Laboratory Support to provide research support administration services for our government customer in Frederick, MD. In this role you will get to perform sample preparation, develop LC-MS methods, and maintain laboratory operations to support various research projects. Regular hours of work with the possibility of Weekends or extra weekly hours if needed. What You'll Be Doing: Perform sample preparation on various matrices, including inactivated cells, tissues, viral particles, and biofluids, using techniques such as purification, homogenization, dialysis, and enzymatic digestion. Develop and perform liquid chromatography mass spectrometry (LC-MS) methods for detecting and characterizing proteins, peptides, metabolites, and other small molecules. Perform SDS-PAGE experiments to separate and assess proteins, nucleic acids, and other biological macromolecules. Develop and perform data analysis workflows, including identification and quantification of peptide sequences, proteins, and small molecules, and statistical comparison of analyte abundance between samples. Maintain research methods, standard operating procedures, and data records, and keep a database inventory of all samples received. Participate in weekly lab meetings, assist in the development and design of current and future work, and prepare technical reports, SOPs, and manuscripts. Maintain an orderly laboratory environment, conduct equipment inventory management twice a year, and perform monthly laboratory management tasks, including safety functions and chemical/supplies inventory. Coordinate ordering of supplies, assist in training new personnel, and communicate experimental data and laboratory issues to the PI or assigned supervisor. Prepare and provide a Functional Capabilities Laboratory Support Progress Report monthly. Ensure laboratory compliance with regulatory guidance, participate in regular decontamination and cleaning, and manage waste disposal. Test emergency showers, eye washes, and drainage systems, and maintain laboratory instrumentation. Present work, attend meetings and training, and engage with partners to support biosurveillance and training missions, requiring CONUS or OCONUS travel approximately 1-2 times per year. Perform other duties as assigned by the supervisor. What Required Skills You'll Bring: Minimum of an Associate's Degree in Biomedical/Biological Science or equivalent training and/or experience (Bachelor's Degree preferred). Experience with sample preparation techniques for various matrices, including inactivated cells, tissues, viral particles, and biofluids. Direct experience with purification, homogenization, dialysis, buffer exchanges, dilutions, concentrations, precipitations, extractions, washes, molecular labeling, and enzymatic digestion. Ability to develop and perform LC-MS methods for detecting and characterizing proteins, peptides, metabolites, and other small molecules. Experience performing SDS-PAGE experiments. Minimum of one (1) year experience in equipment inventory management (GFEBS experience preferred). Minimum of one (1) year experience in laboratory management within BSL-2 and BSL-3 environments, including safety functions and chemical inventory. Must be able to obtain and maintain a NACI clearance. Security Clearance Requirement: None This position is part of our Federal Solutions team. The Federal Solutions segment delivers resources to our US government customers that ensure the success of missions around the globe. Our intelligent employees drive the state of the art as they provide services and solutions in the areas of defense, security, intelligence, infrastructure, and environmental. We promote a culture of excellence and close-knit teams that take pride in delivering, protecting, and sustaining our nation's most critical assets, from Earth to cyberspace. Throughout the company, our people are anticipating what's next to deliver the solutions our customers need now. Salary Range: $15.38 - $26.15 We value our employees and want our employees to take care of their overall wellbeing, which is why we offer best-in-class benefits such as medical, dental, vision, paid time off, 401(k), life insurance, flexible work schedules, and holidays to fit your busy lifestyle! Parsons is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, veteran status or any other protected status. We truly invest and care about our employee's wellbeing and provide endless growth opportunities as the sky is the limit, so aim for the stars! Imagine next and join the Parsons quest-APPLY TODAY! Parsons is aware of fraudulent recruitment practices. To learn more about recruitment fraud and how to report it, please refer to https://www.parsons.com/fraudulent-recruitment/ .

Posted 3 weeks ago

Senior Scientist, Computational Biology-logo
Senior Scientist, Computational Biology
Quantum-Si IncorporatedBranford, CT
We are seeking a highly motivated and experienced Senior Scientist with expertise in computational biology, protein structural modeling and engineering, and machine learning to join the Data Science & Algorithms Team. This role focuses on designing and optimizing protein binders with high affinity for N-terminal amino acid targets, a critical component of our Next-Generation Protein Sequencing kit. You will work at the intersection of protein engineering, machine learning, and structural biology, leveraging state-of-the-art algorithms experimental feedback to develop novel protein scaffolds with tailored binding characteristics. The ideal candidate will have a deep background in Computational Biology, Bioengineering, Structural Biology, or a related field with 5+ years of relevant academic or industry experience. The candidate also must have a strong knowledge of programming languages (e.g. Python, Bash) and protein modeling software (e.g. AlphaFold, ProteinMPNN). Knowledge of fine-tuning or generating new machine-learning models is a plus. As part of our team, your core responsibilities will be: Design, model, and computationally screen protein binders for selective binding to N-terminal amino acid motifs. Develop and optimize binder scaffolds using a combination of structure-based design, ML-driven design, and generative protein modeling tools. Collaborate with wet-lab teams to iteratively test, validate, and refine designs using experimental feedback. Innovate new computational pipelines for high-throughput protein binder discovery. Evaluate binding energetics, specificity, and structural feasibility using in silico approaches. Qualifications PhD. in Computational Biology, Bioengineering, Structural Biology, or a related computational/scientific field Proven expertise in protein structure prediction and design using cutting-edge modeling software (AlphaFold, ProteinMPNN, RFDiffusion, ESM, Rosetta, etc.) Strong understanding of protein-protein and protein-peptide interactions, as well as hands-on experience conducting in silico analyses to evaluate these interactions Experience developing custom computational methods or ML approaches to guide design toward desired structural/functional properties Proficient in programming with Python (preferred) and/or other scripting languages such as Bash; familiarity with JupyterLab, Jupyter Notebooks, or similar virtual notebook environments for data analysis, interactive modeling, and prototyping. Strong analytical thinking and practical problem-solving skills, including the ability to break problems into logical subproblems and devise efficient and flexible solutions Excellent scientific communication and documentation skills, including data summarization and visualization using Python Ideally, you also have these skills/experiences/attributes (but it's ok if you don't!): Publications showcasing the use of advanced protein design tools (e.g., AlphaFold, RFDiffusion, ProteinMPNN) to develop proteins with targeted functions or novel structural features Experience designing binders against unstructured peptide regions, including terminal epitopes or motifs Experience with ML model development or fine-tuning, particularly for structure-function prediction or generative protein design. Experience integrating experimental feedback loops into computational pipelines to improve design success. Familiarity with GPU-accelerated computing and scaling workflows using HPC or cloud resources. Experience with Git The estimated base salary range for this role based in the United States of America is: $130,000 - $155,000. Compensation decisions are dependent on several factors including, but not limited to, level of the position, an individual's skills, knowledge and abilities, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all full-time employees are eligible for our discretionary bonus program and equity as part of the compensation package. Quantum-Si does not accept agency resumes. Quantum-Si is an E-Verify and equal opportunity employer regardless of race, color, ancestry, religion, gender, national origin, sexual orientation, age, citizenship, marital status, disability or Veteran status. All your information will be kept confidential according to EEO guidelines.

Posted 1 week ago

Adjunct Professor- Biology-logo
Adjunct Professor- Biology
Bryant & Stratton CollegeOrchard Park, NY
Unlock your full potential in the innovative and inclusive environment at Bryant & Stratton College. We are a career-focused, private, nonprofit college built differently to serve the needs of students, alumni, associates, employers, and the community. Founded in 1854, Bryant & Stratton College offers real-world education leading to bachelor's, associate's, and professional certificates after completion in the fields of healthcare, technology, legal, business, graphic design, and more Bryant & Stratton College is seeking qualified Biology instructors to teach weekday lectures and laboratory classes at our Southtowns campus. The following areas are needed to be taught: Anatomy & Physiology I and II Pathophysiology REQUIREMENTS: Master's degree in Biology or Zoology, Doctorate in Medicine or Doctor in Chiropractic Ability to meet deadlines, participate in monthly meetings, and contribute to curriculum development in the sciences Professional experience in the scientific/medical field, outside of higher education, preferred Teaching experience in a diverse, career college environment preferred Salary: Generally, courses range between 15 to 45 contact hours so the salary range for this exempt position would be between $825.00 - $2,925.00. Please note that the compensation information is a good faith estimate of the base pay for this position. Information about the total compensation package for this position will be provided during the interview process. All qualified applicants will receive consideration for employment without regard to age, race, ethnicity, national origin, color, religion, disability, marital status, veteran status, sex/gender (including pregnancy or pregnancy related conditions), sexual orientation, gender identity (including transgender status) or any other legally protected characteristics ("protected characteristics"). Bryant & Stratton College is an Equal Opportunity Employer.

Posted 30+ days ago

Postdoctoral Associate | Molecular Biology-logo
Postdoctoral Associate | Molecular Biology
Jackson LaboratoryFarmington, CT
Postdoctoral Associate | Cell and Molecular Biology Hinson Lab Farmington, CT The Hinson lab is seeking an independent, highly motivated PhD-level scientist to join our trans-continental collaborative group funded by the Human Frontiers Science Program (HFSP). The overarching goal of this project is to leverage human pluripotent stem cell technology and advanced structural biology methods to define mechanisms and rules of sarcomere assembly and function. The ideal candidate would have a strong background in cell and molecular biology particularly in stem cell differentiation, advanced imaging and protein-protein interaction studies. As part of the group, this talented individual would have access to a world-class consortium of scientists across pluripotent stem cell biology, 3-dimensional organoids/microtissue assays, super resolution microscopy, and structural biology. The Hinson lab at the Jackson Laboratory for Genomic Medicine and UConn Health utilizes pluripotent stem cell biology, tissue engineering, genome editing, and multi-omics assays to study mechanisms of inherited heart failure and other muscle disorders. QUALIFICATIONS Ph.D. in cell biology, molecular biology, biophysics, biomedical engineering, or related field of study. Prior research experience in at least two of the following areas: pluripotent stem cell biology and differentiation, advanced microscopy, genome editing, and proteomics. Candidates should have a publication record in peer-reviewed journals. Excellent writing and communication skills, able to work independently and effectively with other members in a productive team across continents. Experience with R, Python or similar statistical package is helpful, as well as experience with proteomics data analyses and bioinformatics. Please submit your current CV, at least 2 letters of reference, and 1-page (maximum) statement of Research Interests and Career Goals at time of application. We are a diverse and inclusive research group, aspiring to produce top science and scientists through attentive and progressive mentoring and interdisciplinary teamwork. JAX Salary Year 0 - 1: $65,589 Year 1 - 2: $67,318 Year 2 - 3: $69,095 Year 3 - 4: $70,521 Year 4 - 5: $72,877 Year 5 - 6: $75,569 Based on years of experience as Postdoc About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org. EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

Posted 2 weeks ago

Scientist I, Assay Development for Small Molecule & Antibody Discovery (Biochemistry / Cell Biology)-logo
Scientist I, Assay Development for Small Molecule & Antibody Discovery (Biochemistry / Cell Biology)
1910 GeneticsBoston, Massachusetts
Company Overview 1910 Genetics is a Series A stage biotechnology company that is pioneering a novel Input-Transform-Output (ITO ™ ) platform as the first ever horizontal AI infrastructure for drug discovery. In a crowded space with hundreds of AI drug discovery companies, 1910’s ITO ™ platform is differentiated by: Modality agnostic drug discovery: our platform is capable of designing both small molecule and large molecule therapeutics across all disease areas, with an initial focus on neuroscience, oncology, and autoimmune diseases. Proprietary massive multimodal data, which overcomes the data scarcity problem that prevents frontier AI models from being utilized for drug discovery. Multi-AI agent systems that include a robust collection of frontier AI/ML models, each of which works in a task-oriented manner to achieve the multi-parameter optimization problem of drug discovery and development. A state-of-the-art (SOTA) fully-automated, high throughput wet laboratory in the premier Boston Seaport District for both data generation for AI model training as well as validation of the safety and efficacy of drug candidates that are outputted by our frontier AI models. An unprecedented partnership with Microsoft, which positions 1910 as the only biotech/pharma company leveraging Azure Quantum Elements, a groundbreaking, AI-driven, high performance computing (HPC) cloud architecture for advanced AI. Bespoke conversational AI chatbots that provide a customer friendly UI/UX to access our platform for specific drug discovery tasks. Being the only biotech company helping pharma companies integrate 6 core areas of AI infrastructure. 1910 Genetics is looking for an In Vitro Pharmacology Assay Scientist to work closely with our biologists in the discovery of antibodies. An expert in biochemical characterization of biological drug molecules, the ideal candidate will have experience in antibody drug discovery and characterization of a variety of molecular types. Role Responsibilities Validate target material in functional biochemical assays prior to the start of antibody discovery. Design, validate and execute in vitro biochemical assays for the screening of molecules from 1910 Genetics’ AI-driven large molecule therapeutics platform Develop, validate and execute assays for the biophysical characterization of antibodies in various formats and for various modalities Work closely with 1910 scientists to refine assays to help drive delivery of program objectives Maintain detailed records of experimental procedures and results in electronic lab notebook Present experimental results/progress in a timely manner and contribute to scientific discussion in group meetings Collaborate with cross-functional teams, including AI Research and Computational Chemistry to discuss project updates as well as ensure the project milestones and timelines are met Assist laboratory operations, including maintenance of equipment, reagent tracking and monthly inspections for safety equipment Develop and execute standard operating procedures and best practices to enhance lab efficiency and productivity Contribute to the preparation of scientific reports, presentations, and publications. Provide intellectual input into small molecule projects when required Stay current with scientific literature and emerging technologies in the fields of large and small molecule research Qualifications PhD in Biology with a focus on Biochemistry, Cell Biology, In Vitro Pharmacology, Biomedical Sciences or a related field Postdoctoral experience or relevant industry experience in drug discovery or In Vitro Pharmacology Experience in developing, validating and implementing biology, biochemical, and cell-based assays Familiarity with signal transduction pathways in relevant therapeutic areas such as Immunology & Inflammation, neuroscience, oncology, and cardiomedabolic diseases Experience with immune cell isolation and assay development Experience using analytical techniques/instrumentation for characterization and quantification of large molecules, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography) and RP (Reverse Phase), SEC (Size Exclusion Chromatography), SDS-PAGE, UV-Vis, etc. Familiarity with conjugation, purification and characterization of antibody drug conjugates Excellent problem-solving, critical thinking, and data analysis skills Ability to work independently and as part of a collaborative team in a fast-paced and dynamic research environment Strong track record of research accomplishments, as evidenced by publications in scientific journals #LI-Onsite Diversity and Inclusion (1910’s Promise) At 1910, we believe that a diverse, equitable, and inclusive workplace furthers relevance, resilience, and longevity. We encourage people from all backgrounds, ages, abilities, and experiences to apply. 1910 is proud to be an equal-opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status. If, due to a disability, you need an accommodation during any part of the interview process, please let your recruiter know. While 1910 supports visa sponsorship, sponsorship opportunities may be limited to certain roles and skills. Benefits and Perks Competitive compensation package Above market benefits Generous vacation and parental leave Super cool team building activities Great colleagues

Posted 3 weeks ago

Director of Research Operations (Computational Biology Genomics Laboratory)-logo
Director of Research Operations (Computational Biology Genomics Laboratory)
St. Jude Children's Research HospitalMemphis, Tennessee
St. Jude is seeking a Director of Scientific Research to lead wet laboratory operations in the Department of Computational Biology. This position is key to supporting the development of leading-edge computational tools and improved data analysis of pediatric cancer. About the lab and St. Jude: St. Jude Children’s Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine’s “Best Workplaces in Health Care & Biopharma” and Glassdoor’s “Best Places to Work,” and is located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food and culture. The selected candidate for the Computational Biology Genomics Laboratory (CBGL) will work with faculty within the Department of Computational Biology to further faculty research and facilitate grant applications by ensuring that laboratory staff generate the highest quality data to meet project requirements. This individual will leverage their expertise in Next Generation Sequencing (NGS) platforms and related evolving technologies to inform faculty of potentially useful developments for their research projects. This expertise will also be used to evaluate new technologies and platforms for recommendations for capital purchase. Supervision and management of laboratory infrastructure and common equipment in support of both direct reports and other wet lab personnel within the department will be a component of this position. The selected candidate will supervise 1st level managers and scientists to ensure that the St. Jude ideals of working with purpose and urgency are fulfilled. Job Responsibilities: Lead and direct multiple large/ critical complex lab research areas/teams within area of laboratory research/ focus. Drive and manage scope, schedule, and resources to ensure relevant projects are delivered in line with the needs of the area of laboratory research/focus. Collaborate with cross-functional leadership (e.g., departmental/institutional shared resources, partner laboratories within area of laboratory research/focus and partner/vendor organizations) to optimize research outcomes. Propose innovative & differentiating capabilities/technologies within area of laboratory research/focus (e.g., relevant laboratory research SOPs; research databases; technology platforms) and oversee implementation and adoption. Actively guide budget development, implementation of strategic initiatives and ongoing fiscal review within area of laboratory research/ focus. With Principal Investigator and/or laboratory or research area leadership, actively drive processes for team management, including hiring, goal setting, performance, training and development, and engagement. Perform other duties as assigned to meet the goals and objectives of the department and the institution. Maintain regular and predictable attendance. Minimum Education and/or Training: Bachelor’s degree in relevant scientific discipline is required. Minimum Experience: 10+ years of experience in relevant technical field (industry or academia) is required. 8+ years of experience in relevant technical field is required with a Master’s degree. 5+ years of experience in relevant technical field is required with a PHD. Significant experience in a research functional area with experience managing mid-large teams in a leadership capacity with focus on both achievement of objectives as well as critical skill-building preferred. Experience having led large-scale projects/processes through to implementation preferred. Experience with operational mgmt., budget planning, & stakeholder and resource management preferred. Prior experience in building external connections with peers, emerging technology communities, and expert networks preferred. Experience driving research objectives across area through collaboration with internal and external stakeholders preferred. Proven performance in earlier role/comparable role. Special Skills, Knowledge, and Abilities: Expertise, knowledge, and experience in all aspects of Next Generation Sequencing Expertise in molecular biology. Knowledge of standard biology methods such as tissue culture, immunoblotting, and drug sensitivity assays. Understanding of the organization of computational clusters. Familiarity and experience using command line operations in a shell environment. Ability to translate strategic goals and objectives into actionable tasks, manage budget costs, efficiencies, and communications for optimal results. Skill in managing people, establishing goals and objectives, giving feedback, and having frequent career conversations with staff. Broad knowledge of multiple scientific/research areas and a strong ability to apply those in solving institutional/functional needs. Skills in sourcing, identifying and managing vendor relationships, contract negotiations and holding vendors accountable. Learning agility and strong grasp of vendor provided systems and technologies. Strongly Preferred Skillset: Experience with approaches to generate single-cell sequencing data, such as droplet and combinatorial methods. Familiarity with spatial imaging assays and technologies. Experience using vendor pipelines to process single cell and spatial transcriptomic data (i.e. cell ranger, space ranger). Previous direct report experience. Familiarity with bioinformatics pipelines. Previous experience with fluorescence microscopy. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125,840 - $238,160 per year for the role of Director of Research Operations (Computational Biology Genomics Laboratory). Explore our exceptional benefits ! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Posted 30+ days ago

Postdoctoral Associate- Plant Pathology and Plant-Microbe Biology Section- CALS-logo
Postdoctoral Associate- Plant Pathology and Plant-Microbe Biology Section- CALS
Cornell UniversityIthaca, New York
Academic Job Description Plant Pathology and Plant Microbe Biology Section Postdoctoral Associate The College of Agriculture and Life Sciences (CALS) is a pioneer of purpose-driven science and Cornell University’s second largest college. We work across disciplines to tackle the challenges of our time through world-renowned research, education, and outreach. The questions we probe and the answers we seek focus on three overlapping concerns: We believe that achieving next-generation scientific breakthroughs requires an understanding of the world’s complex, interlocking systems. We believe that access to nutritious food and a healthy environment is a fundamental human right. We believe that ensuring a prosperous global future depends on the ability to support local people and communities everywhere. By working in and across multiple scientific areas, CALS can address challenges and opportunities of the greatest relevance, here in New York, across the nation, and around the world. Position Function This postdoctoral associate position is funded through the NIFA-USDA to conduct research on the ecological, chemical, and the molecular mechanisms that mediate in soil-microbe-plant-insect interactions in Ithaca, NY. Specific duties will include: (1) gather and merge existing data from lab and literature; (2) complete experiments and synthesize data; (3) prepare monthly and yearly updates for funding agency; (4) contribute to lab duties and maintenance of lab safety; (5) complete manuscripts for peer review. The position also includes assistance in initiating new research into the topics described above. Tasks include writing grant proposals, project management, and scientific articles. The post-doc is expected to assist with extension and outreach duties through participation in undergraduate research, farmer/public engagement events/webinars and through presentations at conferences. Anticipated Division of Time Lab research 63% Computer research 15% Field Research 7% Writing 15% Requirements Required: - PhD in Plant Biology, Microbiology, Entomology, Plant Pathology, or a related field. - Experience working with plants as part of their PhD project. - Enthusiastic, strong work ethic, positive attitude, and willingness to work with diverse teams. - Aptitude for organization and multitasking, capacity to work independently and collaboratively within a multidisciplinary and interactive research environment. - Excellent oral and written communication skills - Experience and willingness to mentor early career scientists, including graduate and undergraduate students. Preferred: - Experience in successful grant writing - Experience in leadership and/or management Supervision Exercised This position may supervise students. This position may hire, fire, supervise, and perform performance dialogues for undergraduate students and technical staff. This position will mentor and/or train undergraduate students, graduate students, and technical staff. To apply: Please apply via Academic Jobs Online (https://academicjobsonline.org/ajo/jobs/30026 ). Qualified candidates should submit a short cover letter, curriculum vitae, contact information for three references via the website. Applications will be reviewed as received, continuing until a suitable applicant is identified. CALS hiring range for this title is $61,008 annually. College of Agriculture and Life Sciences Life. Changing. University Job Title: Post Dr Assoc Job Family: Post Doc Other Level: No Grade - Annual Pay Rate Type: Salary Pay Range: $61,008.00 - $87,000.00 Remote Option Availability: Onsite Company: Contract College Contact Name: J'Frances White Job Titles and Pay Ranges: Non-Union Positions Noted pay ranges reflect the potential pay opportunity for each job profile. The hiring rate of pay for the successful candidate will be determined considering the following criteria: Prior relevant work or industry experience Education level to the extent education is relevant to the position Unique applicable skills Academic Discipline To learn more about Cornell’s non-union staff job titles and pay ranges, see Career Navigator . Union Positions The hiring rate of pay for the successful candidate will be determined in accordance with the rates in the respective collective bargaining agreement . To learn more about Cornell’s union wages, see Union Pay Rates . Current Employees: If you currently work at Cornell University, please exit this website and log in to Workday using your Net ID and password. Select the Career icon on your Home dashboard to view jobs at Cornell. Online Submission Guidelines : Most positions at Cornell will require you to apply online and submit both a resume/CV and cover letter. You can upload documents either by “dragging and dropping” them into the dropbox or by using the “upload” icon on the application page. For more detailed instructions on how to apply to a job at Cornell, visit How We Hire on the HR website. Employment Assistance: For general questions about the position or the application process, please contact the Recruiter listed in the job posting or email mycareer@cornell.edu . If you require an accommodation for a disability in order to complete an employment application or to participate in the recruiting process, you are encouraged to contact Cornell University's Office of Institutional Equity and Title IX at voice (607) 255-2242, or email at accommodations@cornell.edu . Applicants that do not have internet access are encouraged to visit your local library, or local Department of Labor. You may also request an appointment to use a dedicated workstation in the Office of Talent Attraction and Recruitment, at the Ithaca campus, by emailing mycareer@cornell.edu . Notice to Applicants: Please read the required Notice to Applicants statement by clicking here . This notice contains important information about applying for a position at Cornell as well as some of your rights and responsibilities as an applicant. EEO Statement: Cornell welcomes students, faculty, and staff with diverse backgrounds from across the globe to pursue world-class education and career opportunities, to further the founding principle of “... any person ... any study.” No person shall be denied employment on the basis of any legally protected status or subjected to prohibited discrimination involving, but not limited to, such factors as race, ethnic or national origin, citizenship and immigration status, color, sex, pregnancy or pregnancy-related conditions, age, creed, religion, actual or perceived disability (including persons associated with such a person), arrest and/or conviction record, military or veteran status, sexual orientation, gender expression and/or identity, an individual’s genetic information, domestic violence victim status, familial status, marital status, or any other characteristic protected by applicable federal, state, or local law. Cornell University embraces diversity in its workforce and seeks job candidates who will contribute to a climate that supports students, faculty, and staff of all identities and backgrounds. We hire based on merit, and encourage people from historically underrepresented and/or marginalized identities to apply. Consistent with federal law, Cornell engages in affirmative action in employment for qualified protected veterans as defined in the Vietnam Era Veterans’ Readjustment Assistance Act (VEVRRA) and qualified individuals with disabilities under Section 503 of the Rehabilitation Act. We also recognize a lawful preference in employment practices for Native Americans living on or near Indian reservations in accordance with applicable law. 2025-05-15

Posted 2 weeks ago

Associate Staff Scientist, Computational Biology & Image Analysis-logo
Associate Staff Scientist, Computational Biology & Image Analysis
The New York Stem Cell FoundationNew York, New York
The New York Stem Cell Foundation (NYSCF) Research Institute is a highly successful nonprofit whose mission is to accelerate cures through stem cell research. Over the past decade, we’ve built automated infrastructure to perform cell biology at an unprecedented scale, allowing us to create some of the largest imaging-based datasets in the world. Using cell models from hundreds to thousands of donors, we are aiming to understand disease progression, unlock novel cellular phenotypes, and work to identify the patients who can benefit most from both existing and new therapeutics. NYSCF is seeking an Associate Staff Scientist to join a growing team of data scientists and engineers in developing and deploying state-of-the-art image processing and analysis pipelines to extract disease-relevant phenotypic insights from high-content imaging experiments. In this role, you will analyze datasets of primary and stem cell-derived cell types, including neurons, beta cells, and fibroblasts. You are a self-motivated applicant with an advanced degree in computer sciences, bioinformatics, medical imaging, physics, biomedical engineering, or a related quantitative discipline. You have a strong background in microscopic image acquisition and/or image processing and analysis and experience in analyzing the effects of genetic or pharmacological perturbations. You will have worked with tools such as CellProfiler and computer vision libraries, including OpenCV. You have applied machine/deep learning approaches to derive insights from image-derived features. What you’ll do: Apply Microscopic Imaging Expertise: Apply advanced knowledge of microscopic imaging techniques to analyze and quality control imaging datasets. Lead Computational Analysis: Design, implement, and optimize computational workflows for analyzing large-scale high-content imaging screens. Advise on experimental design: Help define experimental conditions for high-content screens, identifying and accounting for potential confounders. Pipeline Development: Develop and maintain robust, scalable pipelines for data preprocessing, quality control, feature extraction, and downstream analysis. Innovate in Computer Vision: Employ state-of-the-art computer vision methods to extract meaningful biological insights from imaging data. Collaborative Research: Collaborate with experimental and computational scientists to integrate imaging data with other data modalities (e.g., genomics, transcriptomics).You will be a key team member involved in projects from inception to results. Programming and Software Development: Write efficient, well-documented Python code for image processing, machine learning, and statistical analysis. Data Interpretation and Visualization: Generate compelling visualizations and statistical summaries to communicate findings to a multidisciplinary team. Communication: Present your results at conferences and write scientific papers. What we're looking for: PhD degree in a quantitative discipline (e.g., statistics, computational biology, biomedical engineering, computer science, applied mathematics, or similar) or equivalent practical experience. You are 0-5 years post-completion of your PhD, where you used Python to extract and clean imaging datasets before performing exploratory and statistical data analysis (using linear models, multivariate analysis, predictive modeling and stochastic approaches). You have experience working with biological datasets using tools such as CellProfiler. Strong computer vision expertise, and proficiency in modern image processing and machine learning frameworks (e.g., OpenCV, Scikit-learn, TensorFlow) are a plus. Familiarity with software engineering practices and experience developing production. Software and using cloud computing (AWS preferred). Familiarity with microscopes, scientific imaging, and image analysis. Demonstrated willingness to teach others and learn new techniques. Excellent analytical and communication skills. Nice-to-Have Skills: Familiarity with scientific image analysis tools (ImageJ, FIJI). Familiarity with cell biology. $80,000 - $99,000 a year The base starting salary range for the position is $80,000 to $99,000. Multiple factors, including your experience, determine final offer amounts and levels, which may vary from the amount listed above. This role is classified as exempt. NYSCF has a 35-hour workweek. Why Join NYSCF? At NYSCF, you will be part of a dedicated team that is transforming the landscape of stem cell research and accelerating scientific breakthroughs. This role offers the opportunity to contribute to groundbreaking medical advancements while working in a dynamic and collaborative environment. At NYSCF, we believe diversity in all forms makes us a better team, and we celebrate it. Yet studies have shown that women, people of color, and other minoritized individuals in STEM may be less likely to apply to jobs where they do not meet all of the criteria. Therefore, if you are excited about this role but your past experience does not align perfectly with every qualification in the job description, we encourage you to apply anyway. You may be just the right candidate for this or other roles. We offer all full-time employees a comprehensive benefits package that goes into effect on the first of the month following your start date. It includes a choice of medical, dental, and vision insurance, 403b retirement plan with 2% employer match (immediate vesting schedule which starts after your first 90 days), short and long term insurance, life insurance, inclusive paid parental leave program, pretax transit and parking, legal aid benefits and wellness benefits. Our paid time off includes vacation, sick, personal days, flexible holidays, summer flex program, and all company holidays. If a visa is required, NYSCF will cover all of those costs. Relocation will sometimes be necessary; therefore, we will provide you with an allowance. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and complete the required employment eligibility verification upon hire. NYSCF is an equal opportunity employer, and we value diversity in our organization. We provide equal opportunities to all applicants for employment without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, veteran status, or any other characteristic protected by law. The position is based at our location in Manhattan. Recruitment Phishing Scams: Fake job advertisements and offers are increasingly appearing on the internet. If you have encountered a job posting or have been approached with a job offer that you suspect may be fraudulent, we strongly recommend you do not respond and report it to the Federal Trade Commission and the FBI at https://www.ic3.gov/Home/ComplaintChoice .You can also contact our team jobs@nyscf.org to report details of your experience. Please be mindful of the following: · NYSCF will only reach out to you through an “@nyscf.org” email address. · Other than your email address or telephone number, which you may provide via a job application portal, NYSCF will never ask you to provide personally identifiable information about yourself (such as a Social Security Number or Driver’s License Number) via a messaging application (like that used on the LinkedIn platform or Microsoft Teams or Zoom). · NYSCF will conduct interviews face-to-face over Zoom or in person. · All job postings will be listed on NYSCF's official career page (nyscf.org/careers). If someone contacts you about a job or position that is not listed on the official career page, please contact the NYSCF recruitment team at the contact information below. · If you have any questions regarding the validity of a recruitment inquiry or an interview, please contact the NYSCF’s recruitment team at jobs@nyscf.org to confirm before proceeding.

Posted 3 weeks ago

Scientist/Senior  Scientist, Synthetic Biology (mRNA Therapeutics)-logo
Scientist/Senior Scientist, Synthetic Biology (mRNA Therapeutics)
Kernal BiologicsCambridge, Massachusetts
At Kernal Bio, we engineer human cells inside the body using selective mRNA-LNP technology to treat cancer and autoimmune diseases. Our AI-designed mRNAs, delivered via antibody-decorated lipid nanoparticles (LNPs), ensure precise targeting and minimize off-target effects. Our KR-402 program focuses on hematological malignancies and autoimmune disorders, achieving >90% in vivo delivery efficiency with T-cell-targeted LNPs. The KR-335 program, targeting solid tumors resistant to standard immunotherapies, shows a 100x therapeutic index with strong efficacy and tolerability in preclinical models, including mice and non-human primates. With roots at MIT, Harvard, Merck, and BMS, our management team has spearheaded the development of three FDA-approved therapies and holds over 120 patents. Based in Cambridge, MA, and backed by Hummingbird Ventures, Amgen Ventures, and NASA, Kernal Bio is revolutionizing mRNA therapeutics by leveraging AI to deliver precision treatments within the body. Job Summary: We are seeking a PhD Scientist or a Senior Scientist with deep expertise in using synthetic biology tools to design, engineer, and construct template DNAs for in vitro transcribed (IVT) mRNA production. Successful candidates will also synthesize, purify, and test mRNAs in vitro in various human and murine cell lines. Responsibilities: DNA template design and construction. Partner with external CDMO’s for DNA synthesis and production for research and preclinical DNA. Analyze DNA template quality (e.g., linearization efficiency, poly-A tail length, percentage of supercoiled plasmid) to improve mRNA quality Support internal mRNA production (e.g., IVT reactions chromatography, UFDF) for research and preclinical drug substance Analyze mRNA product quality via Nanodrop, Bioanalyzer, HPLC, etc. Transfect and test IVT mRNAs in vitro in mammalian cell systems Quantify mRNA translation by using ELISA, Flow Cytometer, luminescence etc. Optimize the mRNA production processes Execute high-throughput RNA synthesis, purification, and screening of early-stage drug candidates Independently design and execute experiments to develop and optimize processes for mRNA synthesis Contribute creatively and strategically to assay design, development, and process optimization. Collaborate closely with cross functional teams. Maintain thorough electronic lab notebooks and documentation records Deliver reproducible and impactful results under ambitious timelines, present results in cross-functional meetings to a wide audience, both internally and externally. Proactively evaluate new technologies, be versed with current literature, and implement new features and functionality into DNA & mRNA platforms. Execute and troubleshoot standard protocols, develop and adapt new protocols into practice, and query literature to incorporate additional assays as needed Collect, archive, process, and organize biological samples Identify and lead external research relationships with academic and commercial partners. Requirements: PhD in Biological Engineering, Molecular Biology, Biochemistry, Microbiology, Chemistry, or a related field, with specialization in synthetic biology 4+ years of industry experience preferred for Senior Scientist level. Expertise in RNA vector design, codon engineering, plasmid engineering, in vitro transcription, RNA purification, and transfection in mammalian systems Advanced knowledge and significant experience with primer design, DNA isolation, and DNA assembly (e.g. Gibson) Experience with diverse molecular biology and microbiology techniques for analysis of DNA, RNA, and protein. (e.g RT-qPCR, Western Blots, ddPCR, ELISA, etc.) Experience with routine mammalian cell culture Analysis of protein expression and gene reporter systems with various techniques such as flow cytometry, cell luminescence, and fluorescent microscopy Creative, innovative, and self-driven problem solver with a demonstrated ability to work effectively with highly skilled teams in fast-paced, entrepreneurial environments. Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner. Preferred: in vivo skills with rodents (IV, IP, PO dosing), in vivo imaging, blood/tissue collection. Preferred: Immune cell isolation and transfection experience. Preferred: NGS library preparation experience. Preferred: MPRA experience. Preferred: Experience with automation (e.g., Opentrons) Benefits: Highly competitive healthcare coverage (health, vision, and dental) Flexible Spending Account or Health Savings Account Paid parental leave, family caregiver leaves, medical leave Competitive 401k Paid life insurance coverage Generous vacation and sick days On-site subsidized cafeteria Free monthly subway passes or a subsidized commuter rail pass Free MIT Athletic Membership Free Bluebikes Membership Kernal is dedicated towards providing a diverse work environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in employment practices for reasons of race, color, national origin, age, gender, sexual orientation, marital or veteran status, religion, disability, or any other legally protected status. Kernal will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Posted 30+ days ago

Industrialization Scientist, Molecular Biology-logo
Industrialization Scientist, Molecular Biology
BioMerieuxPhiladelphia, Pennsylvania
Description Industrialization Scientist, Molecular Biology is responsible for planning, implementation and management of PCR processes and products. This individual will be expected to provide scientific guidance and molecular expertise in transferring development projects from R&D into Operations as well as improving the robustness and profitability of existing PCR products and processes. They will ensure Operations and Suppliers have accurate and detailed specifications, SOPs, BOMs, and Product Master Data as well as lead troubleshooting efforts that arise within Supply Chain, QC, and Manufacturing. The ideal candidate will work closely with cross-functional teams including R&D, Quality, Manufacturing, and suppliers to support product lifecycle development and production readiness. Job responsibilities: Maintain a safe work environment and perform work in compliance with company quality procedures and standards. Lead the industrialization of PCR-based molecular diagnostic assays from development through scale-up to full production. Design, implement, and optimize manufacturing processes, ensuring reproducibility, scalability, and regulatory compliance (ISO 9001, ISO 13485, IVDR, etc.). Collaborate with R&D to define product requirements and transfer technical knowledge to production teams. Collaborate with suppliers to define raw material specifications. Support supplier validation efforts and transfer specifications, technical knowledge, and test methods to QC team. Develop and execute technology transfer plans, validation protocols (IQ/OQ/PQ), and risk assessments (e.g., FMEA). Support process validation, troubleshooting, and continuous improvement of manufacturing workflows. Partner with Supply Chain, Purchasing, and suppliers to evaluate potential external or internal suppliers of critical reagents (e.g., enzymes, primers, probes). Implement and monitor quality control (QC) testing strategies for intermediate and final product release. Manage stability studies when applicable following product or process changes and for continuous improvement. Lead troubleshooting and root cause investigation for issues arising from multiple sources, including customer complaints, QC failures, manufacturing challenges, and supplier notifications. Assist with design, implementation, and maintenance of PCR automation. Lead and participate in root cause analysis, CAPAs, and non-conformance investigations. Work with Quality Assurance and Scientific Affairs to ensure compliance with applicable standards and regulations. Mentor engineers, scientists, and technicians throughout Operations. Minimum Requirements: MS in Molecular Biology, Biotechnology, Biochemistry, Chemical Engineering, or related field is required. PhD is preferred. 7 or more years of relevant experience including at least 3 years in manufacturing, industrialization, or product development of molecular diagnostics required. Laboratory experience is required; experience during school is accepted. Laboratory experience in chemistry, microbiology, or molecular biology is preferred. Management experience, including in areas/roles not directly related to MFG, is preferred. Lean MFG or other continuous improvement experience is preferred. Knowledge, Skills, Abilities: Familiarity with manufacturing processes for molecular assays, including raw material synthesis, reagent formulation, lyophilization, and cleanroom environments. Proficient in data analysis tools and statistical methods for process validation. Strong project management and communication skills. Experience with automation and liquid handling platforms is a plus (e.g., Integra, Tecan). Fluency in English (written and spoken); additional languages are an asset. Ability to work with a team, identify and implement feasible solutions to challenges, and independently manage improvement projects and raw materials suppliers required. 10% Domestic Travel per year Please be aware that recruitment related scams are on the rise. Fraudulent job postings are being placed on other websites, and individuals posing as bioMérieux Talent Acquisition team members are reaching out via email or text message in an attempt to collect your personal and confidential information. In some cases, these scammers are also conducting bogus interviews prior to extending fraudulent offers of employment. Beware of individuals reaching out using general phone numbers and non-bioMerieux email domains (i.e. Hotmail.com, Gmail.com, Yahoo.com, etc.). If you are concerned that an interview experience or offer of employment might be a scam, please make sure you are searching for the posting on our careers site https://careers.biomerieux.com/ or contact us at [email protected] . BioMérieux Inc. and its affiliates are Equal Opportunity/Affirmative Action Employers. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Please be advised that the receipt of satisfactory responses to reference requests and the provision of satisfactory proof of an applicant’s identity and legal authorization to work in the United States are required of all new hires. Any misrepresentation, falsification, or material omission may result in the failure to receive an offer, the retraction of an offer, or if already hired, dismissal. If you are a qualified individual with a disability, you may request a reasonable accommodation in BioMérieux’s or its affiliates’ application process by contacting us via telephone at (385) 770-1132, by email at [email protected] , or by dialing 711 for access to Telecommunications Relay Services (TRS).

Posted 1 day ago

2025-2026 Biology Teacher - Propel Braddock Hills High School-logo
2025-2026 Biology Teacher - Propel Braddock Hills High School
Propel SchoolsBraddock Hills, Pennsylvania
Title: Biology Teacher Location: Propel seeks a Teacher for its Propel Braddock Hills High School. This position is for the 2025-2026 school year. Propel schools operate with an extended school year to increase learning time and opportunities for our scholars. We have 190 instructional days (10 more than traditional school districts) and 30 professional development days to better support our teachers and staff for a total of 220 work days annually. Compensation : Propel provides a competitive salary for teachers. Based on relevant prior work experience, our salary range for this role is $49,985- $100,460 (year 3 of salary scale) Relocation Allowance : A relocation allowance for new hires moving to the area from 90 miles away or further. Health Insurance: Medical, dental, and vision plan options at a low cost for individual employees and families. Retirement: New hires participate in a 403(b); Propel contributes 5% automatically and matches up to 4%. This increases after 5 years. Paid Leave: In addition to 2 paid Wellness Days annually, all teachers receive 5 sick days and 10 Personal Days Tuition Assistance: Reimbursement of up to $3,000 annually upon completion of course and receipt of grades for coursework that meets our eligibility requirements. Wellness Benefit: Reimbursement of $20 per month for wellness activities including Gym Memberships, health programs, etc. Additionally, staff have the ability to earn up to $300 for participation in a Wellness Program each year. Professional Development: At Propel, we believe in supporting teacher growth and provide substantial school-based and network-wide professional development support for teachers, including an extensive onboarding process called Induction for new teachers with on-going annual support during the school year called Immersion. All teachers receive 11.5 network-wide Professional Development days annually in addition to school-specific Professional Development. Leadership & Career Development: Leadership opportunities are extensive at Propel, both in and outside of the classroom. Staff have the opportunity to apply for Leadership Pathways as content, grade level or other school-based support roles which allow for experience in many different areas including Content, Wellness, Technology and more. Job Summary: This Teacher position is accountable to collaborate with administrators and staff in planning for and leading students to learning success. This position will be accountable for developing and teaching curriculum based on the Pennsylvania Common Core Standards. Essential Responsibilities: Design coherent instruction using prescribed unit and lesson structures that align with state standards and emerging best practices. Develop and continually update learning resources and actively participate in professional development . Create an instructional environment characterized by respect and rapport that promotes a culture of learning. Use a variety of instructional strategies that engage students in age-appropriate learning, e.g., computer-assisted, cooperative learning, and various student-centered approaches. Manage student behavior and classroom procedures effectively which promotes a safe learning environment. Assess student learning using formal and informal assessment techniques and utilize that information to drive instruction. Implement student IEPs and participate in the special education process as needed. Maintain accurate and up-to date records and report student progress in accordance with school policy and procedure. Prepare and achieve annual performance expectations as prescribed or approved by administration. Communicate with families on a regular basis and reply to family initiated communication in a timely manner. Essential Mindsets Own It. Our teachers are instructional experts who hold high expectations for themselves and their scholars. We work hard, set goals, and take responsibility for our scholars learning. Walk Through the Door. Our teachers are professional with their scholars, families, and colleagues. We show up on time with a positive mindset and never give up on what’s possible for our scholars. Look in the Mirror. Our teachers value feedback and work to continuously improve for our scholars. Our staff is accountable, dedicated and honest. Treat Others the Way You Want to be Treated. Our teachers are culturally competent. In all interactions they are courteous, engaged and empathetic. Do Your Part. Our teachers are relationship builders. We make connections with our scholars, our families, our colleagues and our community and realize that education is a team effort. Why Work at Propel - Science Our goal, as a science team, is to provide all scholars with an inquiry-based learning experience in the classroom that relates to their life outside of the classroom. In our science classrooms scholars work collaboratively, think critically, and actively communicate. Teachers have access to NGSS aligned curricula, such as FOSS in the Primary Grades, STC in the Middle School Grades and Pearson Biology, Chemistry and Pasco Labs in the High School to engage scholars in “doing” science. We also have a number of aligned supplemental resources to provide educators with the tools to differentiate instruction for scholars. During the year we offer learning opportunities in a variety of ways: formal PDs with built in content and grade level team collaboration, embedded departmental and individual coaching, and content data touchpoints and support. Qualifications: Valid PA certification in corresponding content area that is being taught. Strong instructional and classroom management skills High level of personal organization and planning Ability to develop rigorous lesson plans and assessments Deep content area knowledge Strong communication and relationship building skills Willingness to participate in ongoing professional development Ability to utilize data to differentiate instruction A commitment to the Promising Principles of Propel Strong interpersonal skills, cultural competency, high degree of emotional intelligence and self-awareness with the ability to reflect and adapt to diverse environments. Skilled in the use of Google Suite and willingness to experiment and work with new technologies. Physical Demands: Must be able to walk around the classroom at least 75% of the time while engaging with scholars. The person in this position constantly operates a computer and other technology in the classroom to support instruction. The person in this position frequently communicates with various internal and external stakeholders regarding curriculum, instruction and assessment. Must be able to exchange accurate information in these situations When deemed age and/or developmentally appropriate, assist students in daily personal tasks (i.e.-tying shoes, assisting with coats, escorting to busses, and etc.) Disclaimer: This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities and activities may change or new ones may be assigned at any time with or without notice. Organizational Overview Propel Schools is the largest network of public charter schools in Allegheny County consisting of 13 schools and approximately 4,000 scholars. Our mission is to provide high-quality schools to underserved communities. Each of our schools provide a rigorous academic environment and small class sizes where educators focus on providing each scholar with support and individualized attention. With one of the top starting teacher salaries in Allegheny County, a customizable benefits package and extraordinary career and professional development opportunities, Propel Schools is one of the area’s premier education organizations.

Posted 3 weeks ago

Assistant Professor of Biology-logo
Assistant Professor of Biology
High Point UniversityHigh Point, North Carolina
The Department of Biology at High Point University invites applications for two full-time Assistant Professor of Biology positions with an expected start date of August 2025. This position is a 9-month, non-tenure track position eligible for promotion to Associate and Professor ranks and multi-year contract extensions. Responsibilities include teaching introductory and advanced biology courses. There would also be the opportunity to offer interdisciplinary honors and general education courses. The Assistant Professor is responsible for developing an active research program involving undergraduate students. Successful candidates will have a demonstrated commitment to teaching excellence and experiential learning. Successful applicants will have access to startup and institutional research and professional development funding. Preference will be given to candidates with teaching and/or research experience in one or more of the following areas: cell and molecular biology, genetics, human or comparative physiology, human or comparative anatomy, embryology, histology, toxicology, cancer biology, or bioinformatics. A Ph.D. in biology or a closely related field is required, and post-doctoral experience is preferred. The position includes laboratory and office space in our state-of-the-art Wanek School of Natural Sciences, which houses the Departments of Biology, Chemistry, Neuroscience and Physics. The Biology Department offers majors and minors in biology. Biology courses serve as foundational elements of applied and health science degrees at High Point University. The Assistant Professor is responsible for advising biology majors, and for service to the department, school, and university Applications should include the following items, submitted as a single document: (i) a cover letter addressing the applicant’s qualifications and interest in the position, (ii) curriculum vitae, (iii) a statement of teaching philosophy (including a description of approaches to teaching both science and non-science majors), (iv) a statement of research interests, and (v) an unofficial transcript with the highest awarded degree. Additionally, three letters of recommendation should be provided; letters of recommendation should be emailed by references to Dr. Matthew Talbert ( mtalbert@highpoint.edu ). Review of applications will begin on November 1st and will continue until the position is filled. Apply online at https://highpoint.wd1.myworkdayjobs.com/Highpoint-Faculty . For additional information, please contact Dr. Matthew Talbert, mtalbert@highpoint.edu . High Point University does not sponsor H1-B Visas. At High Point University the faculty and staff are devoted to ensuring every student receives an extraordinary education in an inspiring environment with caring people.

Posted 3 weeks ago

Assistant/Associate Professor, Cell Biology/Physiology/Pathology/Immunology-logo
Assistant/Associate Professor, Cell Biology/Physiology/Pathology/Immunology
High Point UniversityHigh Point, North Carolina
The Master of Science in Biomedical Sciences Program in the Department of PA Studies of the Congdon School of Health Sciences, High Point University, is seeking applications for a 12-month faculty position (non-tenure track) at the rank of Assistant/Associate Professor. We seek a candidate with expertise in biomedical sciences such as Cell Biology, Physiology, Pathology, Immunology of Cancer, as well as metabolic, inflammatory, and infectious disease models of human diseases. Applications will be accepted until the position is filled. Salary and academic rank will be based on education and experience. Our Biomedical Science Program is an intensive 11-month interdisciplinary curriculum that focuses on teaching biomedical sciences with a student-centered approach. The program covers human anatomy, biochemistry, cell biology, immunology, pathology, clinical diagnostics and simulation, and the development of biomedical laboratory technical skills. Its goal is to enhance scientific literacy and communication skills. The program culminates in a capstone experience based on inquiry and service learning, with options including a Clinical Experience, Research Development, or Internship track. Below are the primary responsibilities for the successful candidate: 1. Developing and contributing to graduate-level courses in: Cell biology, immunology, physiology, and pathophysiology: This course will encompass concepts in cell biology, immunology, physiology, and the pathophysiology of human diseases which include cancer, metabolic, chronic inflammatory, and infectious diseases. The course will involve lectures and laboratory work. Biomedical Techniques: This lab-based course will focus on teaching standard laboratory techniques and assays used in biomedical research. The aim is to fully train and mentor students in these techniques. Some of the biomedical techniques include real-time PCR, functional cell-based assays (e.g., proliferation, cell death, survival, and energy production), Minimum Inhibitory Concentration assays, immunohistochemistry, Western blots, flow cytometry, microscopy, and cell culture. 2. Additional program teaching responsibilities may include a combination of the following courses: Research Design and Writing, Special Topics, Capstone, and mentoring students in Healthcare Practice and Professional Development (Ethics) or Standardized Exam Prep (MCAT, DAT, GRE). 3. Excelling in academics, mentoring students in research during the capstone experience, and providing guidance for academic and healthcare professions. 4. Establishing a research program that can support successful research projects for master-level students and, optionally, undergraduate students at HPU. The research area and model system are open, with a preference for working with lower animal and cell culture models. QUALIFICATIONS : Applicants must hold a doctoral degree in Cell Biology, Immunology, Physiology, Molecular Biology, or a related field to qualify for this position. They should also have the necessary academic qualifications to teach graduate-level Cell Biology, Immunology, Physiology, and Pathophysiology courses. In addition to the doctoral degree, candidates are required to have further training, such as postdoctoral research experience, clinical practice, STEM workforce credentials, or industry knowledge and practice. Preference will be given to candidates with academic teaching experience at the graduate level or in upper-level undergraduate courses and at least one year of teaching in an educational setting. Applicants with demonstrated experience in mentoring students in research will be highly preferred. KNOWLEDGE, SKILLS, ABILITY: Required: Broad laboratory skills to effectively teach Biomedical Techniques, including cell biology and immunology . Excellent verbal and written communication abilities . Capability to handle multiple tasks and collaborate with others . Willingness to contribute to the educational and research goals of the departments, schools, and universities. Preferred: Record of excellence in teaching and research and a dedication to outstanding education and research. Proficiency in cell-based disease models and related techniques . ESSENTIAL FUNCTIONS: Engage in didactic and laboratory teaching for BMS and other graduate programs in CSHS. The teaching schedule for Summer, Fall, and Spring will be determined in collaboration with the Department Chairs or the Director of the BMS program. Work with BMS and CSHS faculty to create and deliver curricula. Lead instruction for Biomedical Science Courses such as Cell Biology, Immunology, Physiology, and Pathology. Provide mentorship for student inquiry through capstone projects. Offer guidance to students pursuing preprofessional and graduate school goals. Maintain open and effective communication with the Department Chairs and Directors about teaching and research activities. Publish scientific findings in discipline-specific peer-reviewed journals and present at state, regional, national, or international meetings. Foster interdisciplinary collaboration between the Departments of Exercise Science, Physical Therapy, Physician Assistant Studies, Medical Sciences, and Athletic Training in research, education, and service. Contribute to the service missions of the BMS program, the Department of Physician Assistant Studies, Congdon School of Health Sciences, High Point University, and the local community. Act as a representative and advocate for the departments, school, and the university. Actively participate in committees within the departments, school, and university, including professional and governmental organizations. Take on additional duties and responsibilities as assigned by Department Chairs or Directors. All applicants must submit the following as ONE DOCUMENT to HPU’s Workday Portal: (1) a letter of interest addressing teaching expertise and philosophy, research qualifications, and a one-page summary of an ongoing or potential research project; (2) a curriculum vitae with complete professional and academic history; (3) an unofficial transcript of your highest degree awarded; and (4) names and contact information of three professional references. For additional information, please contact Dr. Shanmugam Nagarajan, Program Director, Master of Science in Biomedical Sciences Program, at snagaraj@highpoint.edu .

Posted 30+ days ago

Adjunct Faculty (IvyOnline) - Anatomy and Physiology/Biology-logo
Adjunct Faculty (IvyOnline) - Anatomy and Physiology/Biology
Ivy Tech Community CollegeIndianapolis, Indiana
Online Adjunct Faculty are hired each semester on an as-needed basis. Online Adjunct Faculty are responsible for creating an online learning environment that assists students in reaching their goals and for providing effective instruction and assessment within the framework of the provided single version primary course. Courses are taught completely online in primarily 8-week (rarely 16-week) format. In compliance with the College’s Out of State Workers Policy, only candidates who will reside in and work from the states of Indiana, Illinois, Kentucky, Michigan and Ohio will be considered for this position. Major Responsibilities: - Facilitate student learning by delivering assigned classes in accordance with College policy and course objectives. IvyOnline’s minimum expectations for Online Adjunct Faculty are found in the Academic Support and Operations Manual, Policy 7.5.2. Online Adjunct Faculty are also encouraged to review and implement best practices from the online teaching best practices list. - Make optimal use of available technology to enhance instructional methods. - Supplement and alter, where appropriate, lesson plans, assignments, tests, and materials. Maintain accurate student records, grades, and other requirements. - Engage with students proactively and regularly in meaningful and productive ways that impact student learning and lead to a positive experience with Ivy Tech Community College. - Demonstrate evidence of developing and implementing teaching strategies focused on engaging online students with their learning. - Interact with students and co-workers in a professional and cooperative manner, complying with College policies, guidelines and expectations. - Maintain a safe, quality online educational environment. - Must be committed to an environment where team members feel valued, respected and supported. - Must demonstrate a strong commitment to a workplace culture that recognizes and appreciates varied perspectives, backgrounds, and experiences. Must be passionate about creating and maintaining a team dynamic that encourages open communication and mutual respect. This is not to be construed as an exhaustive list. Other duties logically associated with this position may be assigned. All responsibilities will be conducted within the parameters of the Family Educational Rights and Privacy Act (FERPA), other applicable regulatory requirements, and professional standards. SUPERVISION RECEIVED: Faculty Lead or Assistant Faculty Lead SUPERVISION GIVEN: None Minimum Qualifications: Unofficial transcripts required as part of the application process. Official transcripts required upon hiring. Must have strong working knowledge of current technologies appropriate to area of instruction and meet faculty credentials as outlined in the ASOM 7.1 (see link below) for the specific area(s) of instruction. https://docs.google.com/document/d/1Urmw3PrP-etvOcydlCdsjWgG2N9nP4WoDTHnb6HT2Vc/preview#heading=h.uzffs7dtyei6 A qualified faculty member in anatomy and physiology/biology meets the discipline standard through one of two routes: 1. Possesses an earned master's or higher degree from a regionally accredited institution in a biological science, or 2. Possesses an earned master's or higher degree from a regionally accredited institution in any field with 18 graduate semester hours in biology-related courses. Preferred Qualifications: Previous Online Teaching Experience Other Requirements: Selected candidate for employment will be subject to pre-employment background checks, including criminal history check, and any offer of employment will be contingent upon that outcome. Official transcripts required upon hiring. Please attach unofficial transcripts to application. Ivy Tech Community College is an accredited, equal opportunity/affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, ethnicity, national origin, marital status, religion, sex, gender, sexual orientation, gender identity, disability, age or veteran status. As required by Title IX of the Education Amendments of 1972, Ivy Tech Community College does not discriminate on the basis of sex, including sexual harassment in its educational programs and activities, including employment and admissions. Questions specific to Title IX may be referred to the College’s Title IX Coordinator or to the US Department of Education Office of Civil Rights.

Posted 3 weeks ago

Founding Scientist, Molecular Biology-logo
Founding Scientist, Molecular Biology
General Cybernetics CorporationBoston, Massachusetts
The Company Vault Authority is on track to decisively solve safety and redosability for AAVs. By shielding AAVs in a protein nanoparticle, the AAV is not only protected from neutralizing antibodies, but actively endocytosed by cells at a much higher rate than native AAV transduction. The higher transduction efficiency makes one dose of our technology ~5x cheaper than WT AAV, rendering our platform pareto-superior to legacy AAV therapies. The path ahead is crystal-clear and our only bottleneck is how quickly we can move forward. Apply to join our team today. We're backed by world-class investors including Thiel Capital, Long Journey Ventures, Scott Banister, Balaji Srinivasan and Soma Capital. $120,000 - $200,000 a year The Role • Architect critical molecular biology strategies for our vault-AAV (VAAV) platform and advanced gene therapy programs—encompassing novel plasmid design, GMP-oriented scale-up, and viral vector production. • Oversee and coordinate Research Associates and junior scientists, ensuring project milestones are met while maintaining rigorous safety and quality standards. • Lead cross-functional collaborations with CROs and CDMOs to align technical requirements and ensure on-time delivery. • Develop and refine QC protocols (e.g., ddPCR, qPCR, Western blot, SDS-PAGE), continually optimizing workflows for robust yields, reproducibility, and regulatory compliance. • Manage vendor and stakeholder relationships—overseeing budgets, defining project scopes, and securing critical materials. • Foster a high-performance culture by mentoring team members, setting clear objectives, and providing leadership in troubleshooting complex molecular workflows. • Remain current with emerging tools and breakthroughs in molecular biology to drive continuous innovation in our gene therapy capabilities. Qualifications • Demonstrated passion for pioneering molecular biology solutions in gene therapy or related biotech. • PhD in Molecular Biology, Biochemistry, Genetics, or a related discipline (or equivalent industry background). • 4+ years of postdoc or industry experience with a successful track record in designing and producing plasmids, viral vectors, and recombinant proteins is preferred. • Expertise in advanced molecular techniques (e.g., gene synthesis, cloning, site-directed mutagenesis, large-scale plasmid production, virus purification) plus experience developing and implementing QC methods. • Experience overseeing in vivo studies with transgenic mouse models or relevant animal work in a gene therapy context. • Excellent communication, leadership, and project management skills, including vendor/CRO oversight and interdepartmental collaboration. • Proven ability to develop junior staff, set priorities, and push projects forward under tight timelines in a dynamic research setting. • Willingness to learn new tools, stay informed about cutting-edge methodologies, and contribute novel ideas to the evolution of our gene therapy platform. • Experience at a large pharmaceutical company working in biologics or gene therapy is preferred. Benefits • Medical Insurance: Comprehensive health insurance plans covering a range of services • Dental and Vision Insurance: Coverage for routine dental check-ups, orthodontics, and vision care • Time Off: Generous PTO and Holidays • Parental Leave: Paid maternity and paternity leave to support new parents • Competitive Salary: Industry-standard salaries with opportunities for performance-based bonuses • Retirement Plan: 401(k) plan • Stock Options: Equity options to give employees a stake in the company’s success • Life and Disability Insurance: Basic life insurance and short- and long-term disability coverage • Additional Perks: Unlimited free drinks and snacks in the office

Posted 30+ days ago

Postdoctoral Associate - Sanner Lab - Integrative Structural And Computational Biology-logo
Postdoctoral Associate - Sanner Lab - Integrative Structural And Computational Biology
The Scripps Research InstituteSan Diego, CA
ABOUT US: Scripps Research is a nonprofit biomedical institute ranked as one of the most influential in the world for its impact on innovation. We are celebrating our 100-year legacy. This significant milestone marks a century of seminal discoveries in immunology, infectious diseases (such as COVID-19, flu, HIV), neuroscience, heart disease, cancer, and more. Located in La Jolla, California, the institute houses six research departments, multiple Nobel laureates, a top-ranked graduate school and a leading postdoctoral training program. We work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr to merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and advances in digital and precision medicine. Together, we cultivate new scientific leaders and expand the frontiers of knowledge to deliver medical breakthroughs impacting human health around the globe. If you have a passion for making a difference, this could be your opportunity to join our transformative team. Celebrating a Century: https://100.scripps.edu/ POSITION TITLE: Postdoctoral Associate POSITION SUMMARY: The Sanner lab is part of the Center for Computational Structural Biology (CCSB) at Scripps where we develop cutting edge software for modeling, analyzing, and visualizing molecular interactions which we make available to the worldwide research community. Under the AutoDock Suite umbrella of automated docking software tools we have recently developed AutoDock CrankPep (ADCP in short), a docking engine specifically designed for ab-initio docking of fully flexible peptides. We are seeking a highly motivated and talented individual interested in method development in automated docking and their application to biomedically relevant drug discovery efforts. The successful candidate will join a lab integrated in the highly collaborative CCSB center and continue developing the ADCP software and apply it to biomedically relevant targets. Postdoctoral appointees at Scripps Research are valued for their unique interests and strengths as they conduct their studies alongside over 200 internationally renowned faculty. Postdocs are supported by specialized programming from the institute's Career and Professional Development Office. We see career and professional development as integral to advanced research training for PhD and postdocs, and we provide tailored resources for crafting high-quality manuscripts and grant proposals, planning for your career, and developing your professional skills. Our International Services Office offers expert support for our international scholars, who come to Scripps Research from around the world with a passion and commitment to improving human health. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges. Make Scripps Research your next step to advance and develop your career. Click here to learn more about our Postdoctoral Program and Services: https://education.scripps.edu/postdoctoral/ REQUIREMENTS: The position involves extending the ADCP software code in the C, C++, and Python programming languages, testing the implementation and applying the software to biomedically relevant targets, mostly in the context of collaborations with experimental biologists. We re also working in integrating ADCP with AI methods such as AlphaFold which have emerged and effective peptide docking engines. Candidates holding a PhD in biophysics, or Computer Science with a keen interest in structural biology and biomedical research, or those with PhD/MD in biomedical sciences with substantial experience in scientific programming are encouraged to apply for the position. Candidates interested in combining computational work with wet-lab work are also welcome and could work part-time in collaborators laboratories. Experience in machine learning and deep learning is a plus. Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator. This position works in an office environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process. COMPENSATION: Postdoctoral Associates will be hired following the National Institute of Health and California's exempt salary guidelines, which provide for a starting range of $68,640- $73,230. Consideration will be given to experience that exceeds the listed requirements. COMPREHENSIVE BENEFITS INCLUDE: Eligibility for retirement plans with employer contribution. Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more. Access to Flexible Spending Accounts (Medical/Dependent Care). Competitive vacation and sick leave policies. Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members. Free, on-site parking. Pet Insurance The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff. EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Posted 30+ days ago

Associate Scientist I, Biology (Biochemistry)-logo
Associate Scientist I, Biology (Biochemistry)
PTC TherapeuticsBridgewater, NJ
Job Description Summary: The Associate Scientist I, Biology (Biochemistry) is responsible for performing scientific experiments that contribute to research and drug discovery activities at PTC. This position assists in the conduct of early-stage research, the goal of which is the identification of New Chemical Entities (NCEs), as well as the advancement of research programs from the identification of screening hits to advanced lead optimization. The incumbent is also responsible for communicating experimental results to his/her supervisor and the project team. The Associate Scientist I, Biology supports adherence to all regulatory requirements and company Standard Operating Procedures (SOPs) including as appropriate. . Job Description: ESSENTIAL FUNCTIONS Primary duties/responsibilities: Under limited supervision, executes experiments as directed by the supervisor and communicates results as part of multi-disciplinary team(s). Applies relevant scientific principles and techniques to research problems. Maintains detailed laboratory notebooks. Maintains broad knowledge of state-of-the-art principles and techniques and may contribute to the identification of new project areas or technologies. Presents findings internally and contributes to the publication of the work of the project team in well-established and peer reviewed journals, subject to internal scientific and legal approval. May provide technical and scientific input to the project team or research leadership Contributes to the development of patent applications as appropriate. Complies with all safety requirements. Contributes to general lab operations such as: Equipment maintenance. Identification of capital equipment needs Maintenance of clean and uncluttered work areas Maintain inventory and ordering lab supplies as needed. Provides support for high throughput screening including the design of primary assays, the goal of which is the identification of additional hits and new chemical scaffolds. Provides support for lead optimization by screening compounds and/or supporting structure activity relationship (SAR) studies involving the characterization of the biological activity of compounds in various assays. Profiles selected compounds in additional cells/assays. Provides support for in vivo studies as required. Assists in the development of biologically relevant alternatives to preclinical animal models. Conducts mechanism of drug activity studies. KNOWLEDGE/SKILLS/ABILITIES REQUIRED Extensive knowledge and practical experience in High-Performance Liquid Chromatography (HPLC), with a particular emphasis on analyzing biological samples. Proficiency in flow cytometry and cell sorting techniques, including Fluorescence-Activated Cell Sorting (FACS). Experience in handling human and mouse blood samples Mammalian tissue culture experience, nucleic acid transfection Cell biology and Molecular biology including DNA, RNA and protein purification Endpoint PCR, qPCR and analysis Western blotting Minimum level of education and years of relevant work experience. Bachelor's degree in a scientific discipline, preferably Biochemistry, Biology or Neuroscience with a minimum of 4 years' experience, OR, Master's degree in a scientific discipline with a minimum of 1- 2 years of relevant experience. Special knowledge or skills needed and/or licenses or certificates required. Demonstrates technical proficiency, scientific creativity, and the ability to collaborate with others on cross functional teams in a fast-paced, matrixed, environment consisting of internal and external team members. Possesses knowledge of scientific principles and concepts and keeps current with relevant scientific literature. Proficiency with Microsoft Office- preferably MS Excel and MS PowerPoint. Effective verbal and written communication and skills. Analytical thinker with problem-solving skills and the ability to adapt to changing priorities and deadlines. Effective planning, organization and time management skills including the ability to support and prioritize multiple projects. Special knowledge or skills and/or licenses or certificates preferred. Immunoassay experience - moderate to high-throughput assays for protein detection using different platforms - western blotting, MSD, ELISA Background in neuroscience Experience in assay development Travel requirements Up to 5% Office/Laboratory based position . EEO Statement: PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination. Click here to return to the careers page

Posted 30+ days ago

Postdoctoral Researcher - Synthetic Biology And Metabolic Engineering-logo
Postdoctoral Researcher - Synthetic Biology And Metabolic Engineering
NrelGolden, CO
Posting Title Postdoctoral Researcher - Synthetic Biology and Metabolic Engineering . Location CO - Golden . Position Type Postdoc (Fixed Term) . Hours Per Week 40 . Working at NREL Join the National Renewable Energy Laboratory (NREL), where world-class scientists, engineers, and experts are accelerating energy innovation through breakthrough research and systems integration. From our mission to our collaborative culture, NREL stands out in the research community for its commitment to an affordable and secure energy future. Spanning foundational science to applied systems engineering and analysis, we focus on solving complex challenges to deliver advanced, secure, reliable, and cost-effective energy solutions. Our work helps strengthen U.S. industries, support job creation, and promote national economic growth. At NREL, you'll find a mission-driven environment supported by state-of-the-art facilities, multidisciplinary research teams, and strong collaborations with industry, academia, and other national laboratories. We offer robust professional development opportunities, and a competitive benefits package designed to support your career and well-being. Learn about NREL's critical objectives: NREL's Mission and Vision. Job Description The National Renewable Energy Laboratory (NREL) in Golden, Colorado, is the nation's primary laboratory for research, development, and deployment of renewable energy and energy efficiency technologies. The NREL mission is to develop renewable energy and energy efficient technologies and practices, advance related science and engineering, and transfer knowledge and innovation to address the nation's energy and environmental goals. This position is within the Renewable Resources and Enabling Sciences Center, which is part of Bioeconomy & Sustainable Transportation Directorate, working to advance the technologies to produce bio-based energy, fuels, and products. The successful candidate will work on highly collaborative and interdisciplinary projects, using synthetic biology, systems biology, and metabolic engineering skills and approaches towards developing microbial biocatalysts for the valorization of lignin. The successful candidate will be able to: Work safely and independently in a laboratory setting Plan, execute, and troubleshoot research Collaborate effectively with others within and across disciplines Communicate scientific results effectively, both in written and oral formats Author peer-reviewed publications . Basic Qualifications Must be a recent PhD graduate within the last three years. Must meet educational requirements prior to employment start date. Additional Required Qualifications Research experience in metabolic engineering and synthetic biology Experience in development and implementation of synthetic biology tools Experience in application of systems biology approaches Strong safety record Ability to deliver high-quality results within aggressive timelines Preferred Qualifications Experience designing synthetic operons, constructing plasmids, and building genetically engineered bacterial strains Experience generating and analyzing systems biology datasets, including proteomics, transcriptomics, metabolomics. Experience in Pseudomonas putida or similar bacterial strains . Job Application Submission Window The anticipated closing window for application submission is up to 30 days and may be extended as needed. Annual Salary Range (based on full-time 40 hours per week) Job Profile: Postdoctoral Researcher / Annual Salary Range: $74,900 - $123,600 NREL takes into consideration a candidate's education, training, and experience, expected quality and quantity of work, required travel (if any), external market and internal value, including seniority and merit systems, and internal pay alignment when determining the salary level for potential new employees. In compliance with the Colorado Equal Pay for Equal Work Act, a potential new employee's salary history will not be used in compensation decisions. Benefits Summary Benefits include medical, dental, and vision insurance; short-term disability insurance ; pension benefits ; 403(b) Employee Savings Plan with employer match*; life and accidental death and dismemberment (AD&D) insurance; personal time off (PTO) and sick leave; and paid holidays. NREL employees may be eligible for, but are not guaranteed, performance-, merit-, and achievement- based awards that include a monetary component. Some positions may be eligible for relocation expense reimbursement. Based on eligibility rules Badging Requirement NREL is subject to Department of Energy (DOE) access restrictions. All employees must also be able to obtain and maintain a federal Personal Identity Verification (PIV) card as required by Homeland Security Presidential Directive 12 (HSPD-12), which includes a favorable background investigation. Drug Free Workplace NREL is committed to maintaining a drug-free workplace in accordance with the federal Drug-Free Workplace Act and complies with federal laws prohibiting the possession and use of illegal drugs. Under federal law, marijuana remains an illegal drug. If you are offered employment at NREL, you must pass a pre-employment drug test prior to commencing employment. Unless prohibited by state or local law, the pre-employment drug test will include marijuana. If you test positive on the pre-employment drug test, your offer of employment may be withdrawn. Submission Guidelines Please note that in order to be considered an applicant for any position at NREL you must submit an application form for each position for which you believe you are qualified. Applications are not kept on file for future positions. Please include a cover letter and resume with each position application. . Equal Opportunity Employer All qualified applicants will receive consideration for employment without regard basis of age (40 and over), color, disability, gender identity, genetic information, marital status, domestic partner status, military or veteran status, national origin/ancestry, race, religion, creed, sex (including pregnancy, childbirth, breastfeeding), sexual orientation, and any other applicable status protected by federal, state, or local laws. Reasonable Accommodations E-Verify www.dhs.gov/E-Verify For information about right to work, click here for English or here for Spanish. E-Verify is a registered trademark of the U.S. Department of Homeland Security. This business uses E-Verify in its hiring practices to achieve a lawful workforce.

Posted 1 week ago

Mariana Oncology logo
Senior Scientist, Biology
Mariana OncologyWatertown, MA
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Job Description

Description:

We are seeking a Senior Scientist, Biology to support the discovery of peptide ligands to specific cancer drug targets using mRNA display platform.

Illustrative Breadth of Responsibilities:

  • Design and execute biochemical and cellular experiments to characterize binding activities of radio-peptide ligands to cancer targets. High comfort level working with different kinds of radioemitters is a must.
  • Support hit-lead optimization efforts by screening compounds in a radiolabeled binding assay using cancer cell lines, as well as intellectually contribute towards the screening cascade strategy design.
  • Support internal and external mechanistic biology efforts to understand cell signaling impact of targeting specific cell surface proteins in cancer cell lines.
  • Interpret and analyze data, prepare, and review IND-enabling study reports, communicate findings to project teams, stakeholders, and external collaborators.

Requirements/Skills:

  • Master's degree in Biology, Cell or Molecular Biology, Biotechnology, or a closely related scientific field.
  • 5 years of drug discovery research experience within the biotech or pharmaceutical industries, including:

o 2 years of experience with mRNA display and in vitro translation of unnatural amino acids;

o 5 years of cell-based assay development using techniques including Flow cytometry (MACSQuant platform), live-cell imaging using Incuctye platform, protein quantification/characterization by western blot and ELISA;

o 2 years of experience handling multiple types of radioisotopes to support in vitro assay development; and

o 3 years of IND enabling/post-IND experience.