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Site: Massachusetts Eye and Ear Infirmary

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

SummaryResponsible for the management of multiple clinical research studies and the direct hiring and supervision of Clinical Research Coordinators. Serves as the key liaison with the sponsor, IRB, core laboratories, site P.I.'s, as well as all levels of study staff. Will also coordinate trial initiation, patient recruitment, and expedite project approval and study start-up time. Responsibilities also include participation in developing and maintaining standard operating procedures for the projects, developing advertising strategies to support recruitment activities, oversee budget management and subcontracts with associated institutions.Does this position require Patient Care? NoEssential Functions-Supervises operations of all study staff. -Writes operations manuals. -Participates in the formulation of policies and procedures for the study. -Prepares Case Report Forms. -Coordinates multi-center trials with NIH, FDA and Private foundations. -Reports study progress at investigators' meetings. Project ManagerPosition OverviewWe are seeking an experienced Project Manager to lead and coordinate preclinical research programs in Gene Editing and Gene Therapy for genetic hearing loss. The ideal candidate will oversee cross-functional teams, manage collaborations with external partners (CROs, academic institutions, and biotech companies), and ensure timely and compliant execution of preclinical projects that support early therapeutic development.Key ResponsibilitiesLead planning, execution, and oversight of preclinical gene editing and gene therapy projects, ensuring alignment with program objectives and timelines.Develop and maintain detailed project plans, including goals, milestones, resource, risk management, and budget tracking.Coordinate with internal teams and external collaborators to design, implement, and analyze preclinical studies, including molecular, cellular, and in vivo experiments.Serve as the primary point of contact for communication between stakeholders, including scientific, operational, and regulatory teams.Ensure preclinical studies comply with GLP, GCP, and relevant regulatory standards.Prepare and review study protocols, reports, and other scientific documentation for internal and external submission.Facilitate decision-making by providing data-driven insights, risk assessments, and project status updates.Monitor technological trends in gene editing/gene therapy and recommend innovative approaches to enhance project outcomes.Support business development efforts, including discussions with potential collaborators and partners.Represent the company at conferences, scientific presentations, and partner meetings as needed.QualificationsProven experience in Preclinical Project Management, particularly in gene editing (e.g., CRISPR, ARCUS) or gene therapy programs.Hands-on knowledge of molecular and cellular biology techniques, viral vector handling (AAV, Lentivirus), and in vivo models preferred.Demonstrated ability to manage cross-functional teams and multiple projects simultaneously.Experience with contracting and coordinating work with CROs and external collaborators.Familiarity with regulatory requirements for preclinical studies supporting Investigational New Drug (IND) applications.Strong analytical, problem-solving, and decision-making skills.Excellent verbal and written communication skills, including scientific reporting and stakeholder presentations.Proficient in project management software, Microsoft Office Suite, and data analysis tools.Ability to work independently while fostering collaboration within multidisciplinary teams.Personal AttributesStrong organizational ability, attention to detail, and capability to prioritize tasks in a fast-paced, innovation-driven environment.Proactive, self-motivated, and adaptable, with willingness to “roll up sleeves” and support experimental work as needed.Excellent interpersonal skills, diplomacy, and cultural sensitivity to manage international collaboration.Passion for advancing gene therapy and precision medicine to benefit patients.LocationBoston, Massachusetts, United States (onsite or hybrid options may be considered depending on company policy).

EducationBachelor's Degree Related Field of Study required or Master's Degree Related Field of Study preferredCan this role accept experience in lieu of a degree?NoLicenses and CredentialsExperienceResearch Related Experience 5-7 years required and Supervisory Experience 1-2 years preferredKnowledge, Skills and Abilities- Ability to make independent effective decisions.- Strong organizational and communication Skills.- Ability to effectively supervise and train Staff.- Strong database management and computer skills.- Demonstrated analytical skills to problem solve effectively.- Must possess strong budget management skills.

Onsite243-245 Charles Street40RegularDay (United States of America)

Pay Range

$63,252.80 - $102,596.00/Annual

Grade

7At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.5110 Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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