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Location: Remote, Eastern Territory US

Reporting to: Senior Director, Medical Affairs - Americas

Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the lives of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSCs). Orchard has its global headquarters in London, England, and its U.S. headquarters in Boston, Massachusetts.

Job Summary

The Senior Medical Science Liaison (Sr MSL) is a therapeutic and disease area scientific expert for investigational and approved gene therapy clinical programs. They demonstrate leadership in field medical excellence and coaching as well as medical and scientific support with national level strategic planning in the Eastern Territory of the United States. As a field-based member of the medical affairs team, the Sr MSL will be responsible for developing and enhancing professional relationships with external thought leaders involved in all phases of the clinical development process through a fair-balanced and high-value exchange of clinical and scientific information. In addition to these typical MSL responsibilities, the Sr MSL will develop strategy, serve as a team mentor, and lead national level initiatives. This position necessitates professionals exhibiting established personal and scientific credibility and self-awareness, who work well in a collaborative, cross-functional environment with other individuals within broader US and Global organization.

Key Responsibilities

• Identify, build and maintain collaborative partnerships with healthcare providers (HCP's) and key external experts such as KOL's and academic institutions to become a trusted scientific partner.
• Provide timely, audience-appropriate information and updates to enhance the understanding of the scientific and medical value of Orchard's programs. This includes, but is not limited to, collaboration with Market Access, Government Affairs, Diagnostics, Patient Advocacy, Clinical Development etc.
• Maintain training records and deliver training updates to ensure all personnel in assigned Qualified Treatment Centers are appropriately trained according to Orchard's SOPs and the latest Product Manual.
• Develop a territory profile including Centers of Excellence, key expertise, newborn screening approaches and leaders, and market access pathways to inform medical strategy and tactical planning in collaboration with our Commercial, Diagnostic, and Patient Advocacy partners.
• Gather insights from the field on data, therapeutic area, and competitive intelligence to help inform company strategies and evidence generation plans.
• Build thorough operational understanding to ensure excellence in execution balanced with risk management within the boundaries of all governance processes.
• Review and oversee Investigator-Sponsored Trial (IST) requests and Early Access Program (EAP) requests throughout the internal review process and any follow up requests for information.
• Build effective internal partnerships through communication and collaboration across the organization with individuals from Medical Affairs, Patient Advocacy, Public Affairs, Clinical Development, Clinical Operations, Technical Operations, Market Access, Commercial, etc.
• Ensure compliance with internal and external regulatory and legal guidelines.
• Maintain clinical, scientific, and technical expertise in therapeutic area.
• Develop strategic initiatives to support departmental goals from a field medical excellence perspective
• Successfully manage at least two large cross-functional projects with demonstrated leadership and collaboration skills while successfully maintaining geographical responsibilities
• Proactively seek out and demonstrate successful peer coaching of other team members
• Develop US field resource materials specific to stakeholder group, disease state, and technology.
• Provide strategic insights by maintaining expertise in the therapeutic area and related fields to effectively communicate scientific insights and support strategic objectives
• Monitor the competitive environment for advances and trends in the therapeutic area, including new treatment management and therapies, competitive products and provide feedback to internal stakeholders on specific initiatives of competitors
• Serves as peer leader to mentor and coach new or junior MSLs, supporting onboarding, training, and field excellence