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• Support: Contribute to all Alloy modalities by enabling immunogen preparation, molecular biology reagent generation, protein production, and the greater antibody discovery pipeline
• Improve: Continuously evaluate and optimize standard protocols for transfection, cloning, and protein science workflows to enhance efficiency, reproducibility, and scalability
• Collaborate: Partner closely with cross-functional, multidisciplinary teams across biologics discovery programs and Alloy sites
• Deliver: Apply rigorous scientific thinking to experimental design and execution while maintaining thorough documentation; communicate results clearly to stakeholders to enable informed decision-making and project advancement

• Perform small- to large-scale transient transfections in mammalian cell lines (e.g. CHO) to drive high yield biologics production
• Independently manage multiple cell culture lines maintaining proper tissue culture techniques
• Systematically evaluate and optimize transfection efficiency, cell viability, and expression protocols across scales to improve throughput, consistency, and overall yield
• Execute recombinant DNA workflows, including PCR, Gibson assembly, and plasmid scale-up
• Contribute to antibody construct engineering to support the production of multi-specific antibody candidates
• Support protein expression and purification of biologics using AKTA chromatography systems, including affinity, IEX, and SEC
• Conduct regular QC on biologics including aSEC, CE-SDS or SDS-PAGE, and LAL as needed
• Analyze, interpret, and track deliverables in an electronic laboratory notebook in compliance with industry standards
• Coordinate project handoffs across functional teams to ensure seamless workflow continuity
• Present experimental data and findings during team and departmental meetings 
• Ensure timely execution of project activities in alignment with priorities
• Maintain laboratory organization and ensure compliance with safety protocols

• MS with 2+ years or BS with 4+ years of hands-on research experience in molecular biology or a related discipline
• Degree in appropriate scientific discipline (molecular biology, cell biology, biochemistry, immunology, or related field)
• Extensive experience with transient expression of antibodies using mammalian expression systems from HTP to multi-liter scale, CHO preferred
• Deep technical understanding of various transfection methodologies (e.g., PEI, lipofectamine, or electroporation) and experience optimizing transfection efficiency and cell viability.
• Proficiency in high-density suspension cell culture management, including scale-up strategies from deep-well plates and shaking flasks to bioreactors.
• Hands-on experience monitoring cell culture health and metabolic profiles using analyzers such as Vi-CELL or equivalent instrumentation.
• Proficiency in recombinant DNA techniques including PCR, cloning, restriction digestion, gel analysis, and plasmid purification at small and large scale
• Experience with designing monoclonal, bispecific, and multi-specific constructs
• Strong organizational skills with the ability to manage multiple projects and prioritize independently
• Ability to maintain electronic laboratory notebooks in compliance with industry standards; familiarity with LIMS is a plus. Good communication skills and willingness to learn and adapt as part of a dynamic, team-oriented environment

• Experience in stable cell line generation and vector engineering
• Working knowledge of protein purification techniques, including affinity and size-exclusion chromatography
• Familiarity with bioanalytical techniques to assess protein titer, yield, and purity

• Competitive base and equity compensation commensurate with level of experience and independence
• 401(k) company match

• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)

• Unlimited PTO (paid time off) and flexible schedules
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

Pay TransparencyAt Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated range is $93,000 - $110,000, with the final offer based on factors like your experience, skills, and alignment with our needs.

Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.

We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well-being. If you have any questions about pay or benefits, we’re here to help.

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