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The Company We are Alloy Therapeutics —a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team! The Team The Alloy Genetic Medicines group is innovating a novel RNA-based drug discovery platform, namely “AntiClastic”, spanning the fields of antisense therapeutics to immunomodulating therapeutics. This technology platform was launched by Alloy in 2023 after exclusively licensing its underlying intellectual property which implements a novel spatial conformation of the oligonucleotide developed by Sudhir Agrawal of Arnay Sciences. The team works closely with external partners to discover and develop AntiClastic RNA medicines. The Role Alloy Therapeutics is seeking a visionary and technical leader to serve as the subject matter expert for Bioconjugation and Delivery within our Genetic Medicines Unit. Whether you are a seasoned manager or an elite independent contributor, you will play a pivotal role in bridging the gap between innovative nucleic acid chemistry and transformative therapeutic delivery.You will be responsible for the end-to-end development, documentation, and implementation of process and analytical pipelines for Antibody Oligonucleotide Conjugates (AOCs) and targeted Lipid Nanoparticles (LNPs). This role requires a rare blend of deep technical mastery in conjugation chemistry and a strategic understanding of Quality by Design (QbD) to drive our internal programs and external partnerships forward. Principal Responsibilities Process Leadership: Design and execute robust bioconjugation pipelines for AOCs (utilizing ASOs, siRNA) and targeted LNPs. This includes conjugating oligonucleotides, lipids, and nanoparticles to various targeting domains such as peptides, proteins, and aptamers. Innovation: drive innovation to improve circulating half-life, tissue penetration, cellular uptake, and intracellular bioavailability of payloads Method Development & Analytics: Establish high-resolution analytical methods and pipelines. You will be directly responsible for developing and proceduralizing in-process testing and finished product QC using HPLC (SEC, IEX, IPRP) and LC-MS. QbD & Documentation: Operate withing Quality by Design (QbD) framework, maintaining meticulous records in our Electronic Lab Notebook (ELN). You will iterate between product descriptions and process knowledge to ensure scalable, high-quality manufacturing. Supply Chain & Quality: Lead the review of raw materials and their quality attributes. Define process descriptions and manage technologies required for successful process scale-up. Cross-Functional Collaboration: Act as a central pillar within Genetic Medicines and Alloy, collaborating seamlessly with the Nucleic Acid Chemistry and Biology groups will be essential. You will serve as a primary technical point of contact for external partners. Thought Leadership: Represent Alloy Therapeutics at international conferences and in high-stakes partner presentations, showcasing our cutting-edge delivery capabilities. Qualifications Education: PhD in Chemistry, Biochemistry, Chemical Engineering, or a closely related field. Experience: Minimum of 10 years of post-academic experience, preferably within the biotechnology or pharmaceutical industry. Minimum of 10 years of direct, hands-on experience with AOCs and state-of-the-art bioconjugation technologies. Technical Mastery: Proven track record in developing conjugation chemistries for oligonucleotides (siRNA, ASO) and complex delivery vehicles (LNPs). Expertise in analytical characterization (e.g. SEC-HPLC, IEX, IPRP, LC-MS). Direct experience in process scale-up and tech transfer. Soft Skills: Exceptional communication skills with the ability to translate complex data into actionable insights for diverse audiences, from internal scientists to partners. Taking Care of Our People We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together , we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one. Compensation Competitive base and equity compensation commensurate with level of experience and independence 401(k) company match Health & Family Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered Company-paid disability (STD, LTD) and life insurance Paid parental leave Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval) Unique Perks Unlimited PTO (paid time off) and flexible schedules Annual stipend for continuing education with commitment to your career through individualized professional development plan Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness Pay Transparency At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated annual base salary range is $126,000 - $144,000 with the final offer based on factors like your experience, skills, and alignment with our needs. Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines. We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well-being. If you have any questions about pay or benefits, we’re here to help. Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at recruiting@alloytx.com . We will make every effort to respond to your request for disability assistance as soon as possible. Powered by JazzHR