Program Manager Jobs 2026 (Now Hiring) – Smart Auto Apply

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Us?

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.

• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.

• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview:

We are seeking a Senior Program Manager, CMC to lead and coordinate cross-functional Chemistry, Manufacturing, and Controls (CMC) activities within a cell therapy development and manufacturing environment. The Senior Program Manager, CMC will drive planning, execution, and integration across manufacturing, analytical, quality, regulatory, and supply chain functions to support clinical development and commercialization goals. This role serves as a strategic partner across technical and operational teams, ensuring alignment, proactive risk management, and readiness for key milestones, including regulatory submissions and commercial manufacturing.

Reports to: Senior Director

Location: 13203 Murphy Road Suite 100 Stafford, TX 77477

Basic Qualifications:

• Master's degree in life sciences, medicine, immunology, oncology, pharmacy, health sciences, or a related field

• 6+ years of experience in CMC program/project management or complex project leadership within biotechnology, pharmaceutical, or oncology-focused clinical development environments

• Demonstrated experience leading cross-functional CMC activities, including manufacturing, quality, analytical, and regulatory operations

• Academic or industry experience in cell and gene therapy, immunology/oncology, or bioprocessing/manufacturing sciences

• Proven leadership, stakeholder management, and organizational skills with the ability to manage competing priorities in fast-paced environments

Preferred Qualifications:

• PhD in life sciences, medicine, immunology, oncology, pharmacy, health sciences, or a related field

• Experience supporting late-stage CMC programs in immunology, oncology, or cell and gene therapy

• Proven experience managing complex programs and critical paths across multiple technical and operational functions

• Proficiency with project management tools, dashboards, and reporting systems in regulated environments

• Advanced ability to identify risks, drive decision-making, and implement process improvements across cross-functional teams

• Experience coordinating external vendors, CMOs, CDMOs, or consulting partners

• Strong communication and presentation skills with experience supporting senior leadership discussions and strategic planning

In this role you will:

• Develop and maintain CMC program plans, timelines, risk registers, trackers, and reporting tools to support integrated program execution

• Manage CMC deliverables, milestones, and critical paths while ensuring alignment with overarching development program timelines

• Lead and facilitate cross-functional CMC meetings, including agenda development, documentation, action tracking, and follow-up activities

• Drive collaboration across Manufacturing, Process Development, Analytical Development, Quality, Regulatory, Supply Chain, and Patient Operations teams

• Coordinate and oversee activities with external vendors, contractors, CMOs, and CDMOs

• Support strategic planning, governance, and decision-making activities with department leaders and senior management

• Contribute to continuous improvement of CMC program management tools, processes, onboarding, and operational best practices

What do we offer?

At Immatics, we believe in investing in our team's health, safety and well-being. Here's what you can expect if you join Immatics

Comprehensive Benefits:

• Competitive rates for Health, Dental, and Vision Insurance

• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.

• 12 company paid holidays

• 7 days of sick time

• 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars

• 100% employer-paid short- and long-Term disability coverage

• 401(k) with immediate eligibility and company match…

• The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.

• Partially paid parental leave for eligible employees.

• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

Equal Employment Opportunity

We are an equal opportunity employer and are committed to building a diverse and inclusive workplace.  We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law.

Reasonable Accommodations

We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices, or observances.  If you require assistance or accommodation during the application or interview process, please contact us at RecruitingUS@immatics.com.

Work Authorization

Applicants must be authorized to work in the United States without the need for current or future sponsorship.  Visa sponsorships may be available for certain roles.

Pre-Employment Requirements

Employment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law.  For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.